Study · Animal study (in vivo) · mouse · 2016
11 resultsde Picciotto NE, Gano LB, Johnson LC, Martens CR, Sindler AL, Mills KF, Imai S, Seals DR
Aging cell11 Mar 2016Cited by 338 (Europe PMC)
11 results from studies that gave the peptide. No result from this study comes from people.
In old mice, NMN restored endothelium-dependent dilation.
In plain wordsIn old mice, NMN restored artery dilation compared with old controls.
mousen: not reported in source
old miceMeasurements
Source sentences
Supplementation with NMN in old mice restored EDD (86 ± 2%) and NO-mediated EDD (61 ± 5%),
In old mice, NMN restored nitric oxide-mediated endothelium-dependent dilation.
In plain wordsIn old mice, NMN restored nitric oxide-mediated artery dilation compared with old controls.
mousen: not reported in source
old miceMeasurements
Source sentences
Supplementation with NMN in old mice restored EDD (86 ± 2%) and NO-mediated EDD (61 ± 5%),
In old mice, NMN reduced aortic pulse wave velocity.
In plain wordsIn old mice, NMN reduced a measure of artery stiffness compared with old controls.
mousen: not reported in source
old miceMeasurements
Source sentences
reduced aPWV (359 ± 14 cm s(-1) ) and EM (3694 ± 315 kPa),
In old mice, NMN reduced arterial elastic modulus.
In plain wordsIn old mice, NMN reduced arterial elastic modulus compared with old controls.
mousen: not reported in source
old miceMeasurements
Source sentences
reduced aPWV (359 ± 14 cm s(-1) ) and EM (3694 ± 315 kPa),
In old mice, NMN normalized aortic superoxide production.
In plain wordsIn old mice, NMN normalized artery superoxide production compared with old controls.
mousen: not reported in source
old miceMeasurements
Source sentences
normalized O2- production (0.9 ± 0.1 AU), decreased nitrotyrosine, reversed collagen-I, increased elastin, and restored vascular SIRT1 activity.
In old mice, NMN decreased nitrotyrosine abundance.
In plain wordsIn old mice, NMN reduced nitrotyrosine compared with old controls.
mousen: not reported in source
old miceSource sentences
normalized O2- production (0.9 ± 0.1 AU), decreased nitrotyrosine, reversed collagen-I, increased elastin, and restored vascular SIRT1 activity.
In old mice, NMN reversed the age-associated increase in collagen-I.
In plain wordsIn old mice, NMN reversed increased artery collagen-I compared with old controls.
mousen: not reported in source
old miceSource sentences
normalized O2- production (0.9 ± 0.1 AU), decreased nitrotyrosine, reversed collagen-I, increased elastin, and restored vascular SIRT1 activity.
OC had greater aortic O2- production (2.0 ± 0.1 vs. 1.0 ± 0.1 AU), nitrotyrosine abundance (a marker of oxidative stress), and collagen-I, and reduced elastin and vascular SIRT1 activity, measured by the acetylation status of the p65 subunit of NFκB, compared with YC.
In old mice, NMN increased elastin.
In plain wordsIn old mice, NMN increased artery elastin compared with old controls.
mousen: not reported in source
old miceSource sentences
normalized O2- production (0.9 ± 0.1 AU), decreased nitrotyrosine, reversed collagen-I, increased elastin, and restored vascular SIRT1 activity.
In old mice, NMN restored vascular SIRT1 activity.
In plain wordsIn old mice, NMN restored artery SIRT1 activity compared with old controls.
mousen: not reported in source
old miceSource sentences
normalized O2- production (0.9 ± 0.1 AU), decreased nitrotyrosine, reversed collagen-I, increased elastin, and restored vascular SIRT1 activity.
In isolated mouse aortas, acute NMN incubation increased NAD threefold.
In plain wordsIn lab tests, acute NMN exposure increased NAD threefold in isolated mouse arteries.
mousen: not reported in source
isolated mouse aortasMeasurements
Source sentences
Acute NMN incubation in isolated aortas increased NAD(+) threefold and manganese superoxide dismutase (MnSOD) by 50%.
In isolated mouse aortas, acute NMN incubation increased manganese superoxide dismutase by 50%.
In plain wordsIn lab tests, acute NMN exposure increased manganese superoxide dismutase by 50% in isolated mouse arteries.
mousen: not reported in source
isolated mouse aortasMeasurements
Source sentences
Acute NMN incubation in isolated aortas increased NAD(+) threefold and manganese superoxide dismutase (MnSOD) by 50%.
AI wrote and checked these results. AI can make mistakes, so check important results against the source.
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Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC
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