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Study · Ex vivo tissue · mouse and rat · 2016

3 results

The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase.

Kumar N, Nakagawa P, Janic B, Romero CA, Worou ME, Monu SR, Peterson EL, Shaw J, Valeriote F, Ongeri EM, Niyitegeka JM, Rhaleb NE, Carretero OA

American journal of physiology. Renal physiology9 Mar 2016Cited by 47 (Europe PMC)

PMID26962108 (opens in a new tab)PMCIDPMC4889319 (opens in a new tab)DOI10.1152/ajprenal.00562.2015 (opens in a new tab)PepBankPUB-26962108
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    Incubation of Tβ4 with rat kidney homogenates significantly released Ac-SDKP, which the meprin-α inhibitor actinonin blocked.

    In plain wordsIn lab tests, rat kidney tissue released Ac-SDKP from Tβ4, and a meprin-α blocker stopped this.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseAc-SDKP release from Tβ4 in kidney homogenate
    Study

    ratn: not reported in source

    rat kidney homogenate
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Incubation of Tβ4 with rat kidney homogenates significantly released Ac-SDKP, which was blocked by the meprin-α inhibitor actinonin.
  2. 02LabEx vivo tissueMechanism

    Kidney homogenates from meprin-α knockout mice failed to release Ac-SDKP from Tβ4.

    In plain wordsIn lab tests, kidney tissue from mice lacking meprin-α did not release Ac-SDKP from Tβ4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeAc-SDKP release from Tβ4 by meprin-α KO kidney homogenate
    Study

    mousen: not reported in source

    kidney homogenate from meprin-α knockout mice
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kidney homogenates from meprin-α KO mice failed to release Ac-SDKP from Tβ4.
  3. 03LabIn vitro (cell-free)Mechanism

    In vitro, incubation of Tβ4 with both meprin-α and POP released Ac-SDKP, whereas neither enzyme alone released it.

    In plain wordsIn lab tests, Tβ4 released the Ac-SDKP fragment only when both meprin-α and POP were present.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseAc-SDKP release from Tβ4 by meprin-α and POP together
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, we found that the incubation of Tβ4 with both meprin-α and POP released Ac-SDKP, whereas no Ac-SDKP was released when Tβ4 was incubated with either meprin-α or POP alone.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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