In healthy adults, methylene blue reduced cerebral blood flow in a task-related network during a visuomotor task.
In plain wordsIn healthy adults, methylene blue reduced task-related brain blood flow compared with placebo.
- Peptide
- Methylene blue
- Outcome
- DecreaseTask-related cerebral blood flow
- Study
n: not reported in source
- Comparator
- Placebo
- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- single low dose · oralAs given in this study (human).
Source sentences
MB administration was associated with a reduction in cerebral blood flow in a task-related network during a visuomotor task, and with stronger resting-state functional connectivity in multiple regions linking perception and memory functions.
2 context sentences(design, population, supporting numbers)
We tested the hypothesis that a single low oral dose of MB modulates the functional connectivity of neural networks in healthy adults.
Task-based and task-free fMRI were performed before and one hour after MB or placebo administration utilizing a randomized, double-blinded, placebo-controlled design.