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Study · Randomized controlled trial · n = 11 · 2016

13 results

Short-term effects of liraglutide on kidney function and vasoactive hormones in type 2 diabetes: a randomized clinical trial.

Skov J, Pedersen M, Holst JJ, Madsen B, Goetze JP, Rittig S, Jonassen T, Frøkiaer J, Dejgaard A, Christiansen JS

Diabetes, obesity & metabolism22 Mar 2016Cited by 116 (Europe PMC)

PMID26910107 (opens in a new tab)DOI10.1111/dom.12651 (opens in a new tab)PepBankPUB-26910107
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. 13 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In men with type 2 diabetes, a single dose of liraglutide had no effect on glomerular filtration rate compared with placebo.

    In plain wordsIn men with type 2 diabetes, one dose of liraglutide did not change kidney filtration compared with placebo.

    Peptide
    Liraglutide
    Outcome
    No significant changeGlomerular filtration rate
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    1.2 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    Liraglutide had no effect on GFR [95% confidence interval (CI) -6.8 to 3.6 ml/min/1.73 m(2) ]
    1 context sentence
    Summary · context
    The study was a placebo-controlled, double-blind, crossover trial in 11 male patients with type 2 diabetes.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In men with type 2 diabetes, a single dose of liraglutide had no effect on renal blood flow compared with placebo.

    In plain wordsIn men with type 2 diabetes, one dose of liraglutide did not change blood flow to the kidneys compared with placebo.

    Peptide
    Liraglutide
    Outcome
    No significant changeRenal blood flow
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    1.2 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    or on RBF (95% CI -39 to 30 ml/min)
    1 context sentence
    Summary · context
    The study was a placebo-controlled, double-blind, crossover trial in 11 male patients with type 2 diabetes.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In men with type 2 diabetes, a single dose of liraglutide did not change local renal blood perfusion or oxygenation compared with placebo.

    In plain wordsIn men with type 2 diabetes, one dose of liraglutide did not change kidney perfusion or oxygen levels compared with placebo.

    Peptide
    Liraglutide
    Outcome
    No significant changeRenal perfusion and oxygenation
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    1.2 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    did not change local renal blood perfusion or oxygenation.
    1 context sentence
    Summary · context
    The study was a placebo-controlled, double-blind, crossover trial in 11 male patients with type 2 diabetes.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In men with type 2 diabetes, a single dose of liraglutide increased the fractional excretion of lithium by 14%, a marker of reduced proximal tubular sodium reabsorption.

    In plain wordsIn men with type 2 diabetes, one dose of liraglutide raised lithium excretion, a marker of how the kidney handles sodium, compared with placebo.

    Peptide
    Liraglutide
    Outcome
    IncreaseFractional excretion of lithium
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    1.2 mg · single doseAs given in this study (human).

    Measurements

    Fractional excretion of lithium increase
    14%
    liraglutide

    Source sentences

    Summary
    The fractional excretion of lithium increased by 14% (p = 0.01)
    1 context sentence
    Summary · context
    The study was a placebo-controlled, double-blind, crossover trial in 11 male patients with type 2 diabetes.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In men with type 2 diabetes, sodium clearance tended to increase after a single dose of liraglutide, but the change was not significant.

    In plain wordsIn men with type 2 diabetes, sodium clearance tended to rise after one dose of liraglutide, but the change was not statistically significant.

    Peptide
    Liraglutide
    Outcome
    No significant changeSodium clearance
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    1.2 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    sodium clearance tended to increase (p = 0.06).
    1 context sentence
    Summary · context
    The study was a placebo-controlled, double-blind, crossover trial in 11 male patients with type 2 diabetes.
  6. 06HumanRandomized controlled trialSafety outcome

    In men with type 2 diabetes, a single dose of liraglutide increased diastolic blood pressure by 3 mm Hg compared with placebo.

    In plain wordsIn men with type 2 diabetes, one dose of liraglutide raised diastolic blood pressure by 3 mm Hg compared with placebo.

    Peptide
    Liraglutide
    Outcome
    IncreaseDiastolic blood pressure
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1.2 mg · single doseAs given in this study (human).

    Measurements

    Diastolic blood pressure increase
    3 mm Hg
    liraglutide

    Source sentences

    Summary
    Liraglutide increased diastolic and systolic blood pressure (3 and 6 mm Hg) and heart rate (2 beats per min; all p < 0.05).
    1 context sentence
    Summary · context
    The study was a placebo-controlled, double-blind, crossover trial in 11 male patients with type 2 diabetes.
  7. 07HumanRandomized controlled trialSafety outcome

    In men with type 2 diabetes, a single dose of liraglutide increased systolic blood pressure by 6 mm Hg compared with placebo.

    In plain wordsIn men with type 2 diabetes, one dose of liraglutide raised systolic blood pressure by 6 mm Hg compared with placebo.

    Peptide
    Liraglutide
    Outcome
    IncreaseSystolic blood pressure
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1.2 mg · single doseAs given in this study (human).

    Measurements

    Systolic blood pressure increase
    6 mm Hg
    liraglutide

    Source sentences

    Summary
    Liraglutide increased diastolic and systolic blood pressure (3 and 6 mm Hg) and heart rate (2 beats per min; all p < 0.05).
    1 context sentence
    Summary · context
    The study was a placebo-controlled, double-blind, crossover trial in 11 male patients with type 2 diabetes.
  8. 08HumanRandomized controlled trialSafety outcome

    In men with type 2 diabetes, a single dose of liraglutide increased heart rate by 2 beats per minute compared with placebo.

    In plain wordsIn men with type 2 diabetes, one dose of liraglutide raised heart rate by 2 beats per minute compared with placebo.

    Peptide
    Liraglutide
    Outcome
    IncreaseHeart rate
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1.2 mg · single doseAs given in this study (human).

    Measurements

    Heart rate increase
    2 beats per min
    liraglutide

    Source sentences

    Summary
    Liraglutide increased diastolic and systolic blood pressure (3 and 6 mm Hg) and heart rate (2 beats per min; all p < 0.05).
    1 context sentence
    Summary · context
    The study was a placebo-controlled, double-blind, crossover trial in 11 male patients with type 2 diabetes.
  9. 09HumanRandomized controlled trialMechanism

    In men with type 2 diabetes, a single dose of liraglutide decreased angiotensin II concentration by 21% compared with placebo.

    In plain wordsIn men with type 2 diabetes, one dose of liraglutide lowered angiotensin II, a blood-pressure hormone, by 21% compared with placebo.

    Peptide
    Liraglutide
    Outcome
    DecreaseAngiotensin II concentration
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    1.2 mg · single doseAs given in this study (human).

    Measurements

    Angiotensin II decrease
    21%
    liraglutide

    Source sentences

    Summary
    Angiotensin II (ANG II) concentration decreased by 21% (p = 0.02)
    1 context sentence
    Summary · context
    The study was a placebo-controlled, double-blind, crossover trial in 11 male patients with type 2 diabetes.
  10. 10HumanRandomized controlled trialMechanism

    In men with type 2 diabetes, a single dose of liraglutide had no effect on other renin-angiotensin system components.

    In plain wordsIn men with type 2 diabetes, one dose of liraglutide did not change other blood-pressure hormones of the renin-angiotensin system.

    Peptide
    Liraglutide
    Outcome
    No significant changeOther renin-angiotensin system components
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    1.2 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    but there were no effects on other renin-angiotensin system components, atrial natriuretic peptides (ANPs), methanephrines or excretion of catecholamines.
    1 context sentence
    Summary · context
    The study was a placebo-controlled, double-blind, crossover trial in 11 male patients with type 2 diabetes.
  11. 11HumanRandomized controlled trialMechanism

    In men with type 2 diabetes, a single dose of liraglutide had no effect on atrial natriuretic peptides.

    In plain wordsIn men with type 2 diabetes, one dose of liraglutide did not change atrial natriuretic peptide levels.

    Peptide
    Liraglutide
    Outcome
    No significant changeAtrial natriuretic peptides
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    1.2 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    there were no effects on other renin-angiotensin system components, atrial natriuretic peptides (ANPs)
    1 context sentence
    Summary · context
    The study was a placebo-controlled, double-blind, crossover trial in 11 male patients with type 2 diabetes.
  12. 12HumanRandomized controlled trialMechanism

    In men with type 2 diabetes, a single dose of liraglutide had no effect on methanephrines.

    In plain wordsIn men with type 2 diabetes, one dose of liraglutide did not change methanephrine levels.

    Peptide
    Liraglutide
    Outcome
    No significant changeMethanephrines
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    1.2 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    there were no effects on other renin-angiotensin system components, atrial natriuretic peptides (ANPs), methanephrines or excretion of catecholamines.
    1 context sentence
    Summary · context
    The study was a placebo-controlled, double-blind, crossover trial in 11 male patients with type 2 diabetes.
  13. 13HumanRandomized controlled trialMechanism

    In men with type 2 diabetes, a single dose of liraglutide had no effect on excretion of catecholamines.

    In plain wordsIn men with type 2 diabetes, one dose of liraglutide did not change catecholamine excretion.

    Peptide
    Liraglutide
    Outcome
    No significant changeCatecholamine excretion
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    1.2 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    there were no effects on other renin-angiotensin system components, atrial natriuretic peptides (ANPs), methanephrines or excretion of catecholamines.
    1 context sentence
    Summary · context
    The study was a placebo-controlled, double-blind, crossover trial in 11 male patients with type 2 diabetes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:10 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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