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Study · In vitro (cells) · giant panda (receptor) · 2016

2 results

Molecular cloning and pharmacological characterization of giant panda (Ailuropoda melanoleuca) melanocortin-4 receptor.

Wang ZQ, Wang W, Shi L, Chai JT, Zhang XJ, Tao YX

General and comparative endocrinology16 Feb 2016Cited by 6 (Europe PMC)

PMID26896843 (opens in a new tab)DOI10.1016/j.ygcen.2016.02.016 (opens in a new tab)PepBankPUB-26896843
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In HEK293T cells expressing giant panda MC4R, NDP-MSH bound the receptor with the highest affinity of the 4 agonists, the same ranking as human MC4R.

    In plain wordsIn cells, NDP-MSH bound the giant panda MC4R receptor more strongly than the other three agonists.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableBinding affinity to giant panda MC4R
    Study

    giant panda (receptor)n: not reported in source

    amMC4R expressed in HEK293T cells
    Comparator
    THIQ, alpha-MSH, beta-MSH
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We showed that amMC4R bound NDP-MSH with the highest affinity followed by THIQ, α-MSH, and β-MSH, with the same ranking order as hMC4R.
    1 context sentence
    Summary · context
    With human MC4R (hMC4R) as a control, pharmacological characteristics of amMC4R were analyzed with binding and signaling assays.
  2. 02LabIn vitro (cells)Activity measurement

    In HEK293T cells expressing giant panda MC4R, NDP-MSH caused a dose-dependent increase of intracellular cAMP, with EC50 similar to the other three agonists.

    In plain wordsIn cells, NDP-MSH raised cAMP in a dose-dependent way through the giant panda MC4R receptor, like the other agonists.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreasecAMP increase via giant panda MC4R
    Study

    giant panda (receptor)n: not reported in source

    amMC4R expressed in HEK293T cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment of HEK293T cells expressing amMC4R with different concentrations of agonists resulted in dose-dependent increase of intracellular cAMP levels, with similar EC50s for the four agonists.
    1 context sentence
    Summary · context
    With human MC4R (hMC4R) as a control, pharmacological characteristics of amMC4R were analyzed with binding and signaling assays.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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