Stable gastric pentadecapeptide BPC 157 heals rat colovesical fistula.

Grgic T, Grgic D, Drmic D, Sever AZ, Petrovic I, Sucic M, Kokot A, Klicek R, Sever M, Seiwerth S, Sikiric P

European journal of pharmacology11 Feb 2016Cited by 16 (Europe PMC)

PMID26875638DOI10.1016/j.ejphar.2016.02.038PepBankPUB-26875638

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with colovesical fistula, BPC‑157 given perorally or intraperitoneally rapidly improved the whole presentation.
In plain wordsIn rats with a gut-bladder fistula, BPC‑157 quickly improved the whole condition compared with controls.
Peptide
BPC-157
Outcome
IncreaseOverall healing of colovesical fistula
Study
ratn: not reported in source
Wistar Albino male rats
Comparator
Saline or water controls
Outcome group
Wound healing · Gastrointestinal
Studied dose
10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).
Source sentences
Summary
By contrast, BPC 157 given perorally or intraperitoneally and in µg- and ng-regimens rapidly improved the whole presentation, with both colon and vesical defects simultaneously ameliorated and eventually healed.
2 context sentences(design, population, supporting numbers)
Summary · context
To establish the effects of BPC 157 on the healing of rat colovesical fistulas, Wistar Albino male rats were randomly assigned to different groups.
Summary · context
BPC 157 was provided daily, perorally, in drinking water (10µg/kg, 12ml/rat/day) until sacrifice or, alternatively, 10µg/kg or 10ng/kg intraperitoneally, with the first application at 30min after surgery and the last at 24h before sacrifice.
Report a problemFND-2687563801
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with colovesical fistula, BPC‑157 ameliorated the colon defect, which eventually healed.
In plain wordsIn rats with a gut-bladder fistula, BPC‑157 helped the gut defect heal compared with controls.
Peptide
BPC-157
Outcome
DecreaseColon defect
Study
ratn: not reported in source
Wistar Albino male rats
Comparator
Saline or water controls
Outcome group
Wound healing · Gastrointestinal
Studied dose
10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).
Source sentences
Summary
By contrast, BPC 157 given perorally or intraperitoneally and in µg- and ng-regimens rapidly improved the whole presentation, with both colon and vesical defects simultaneously ameliorated and eventually healed
2 context sentences(design, population, supporting numbers)
Summary · context
To establish the effects of BPC 157 on the healing of rat colovesical fistulas, Wistar Albino male rats were randomly assigned to different groups.
Summary · context
BPC 157 was provided daily, perorally, in drinking water (10µg/kg, 12ml/rat/day) until sacrifice or, alternatively, 10µg/kg or 10ng/kg intraperitoneally, with the first application at 30min after surgery and the last at 24h before sacrifice.
Report a problemFND-2687563802
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with colovesical fistula, BPC‑157 ameliorated the vesical defect, which eventually healed.
In plain wordsIn rats with a gut-bladder fistula, BPC‑157 helped the bladder defect heal compared with controls.
Peptide
BPC-157
Outcome
DecreaseVesical defect
Study
ratn: not reported in source
Wistar Albino male rats
Comparator
Saline or water controls
Outcome group
Wound healing · Kidney and urinary
Studied dose
10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).
Source sentences
Summary
By contrast, BPC 157 given perorally or intraperitoneally and in µg- and ng-regimens rapidly improved the whole presentation, with both colon and vesical defects simultaneously ameliorated and eventually healed
2 context sentences(design, population, supporting numbers)
Summary · context
To establish the effects of BPC 157 on the healing of rat colovesical fistulas, Wistar Albino male rats were randomly assigned to different groups.
Summary · context
BPC 157 was provided daily, perorally, in drinking water (10µg/kg, 12ml/rat/day) until sacrifice or, alternatively, 10µg/kg or 10ng/kg intraperitoneally, with the first application at 30min after surgery and the last at 24h before sacrifice.
Report a problemFND-2687563803
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with colovesical fistula, the maximal instilled volume rose until it reached the values of healthy rats.
In plain wordsIn rats with a gut-bladder fistula treated with BPC‑157, the bladder volume reached the level of healthy rats.
Peptide
BPC-157
Outcome
IncreaseMaximal instilled volume
Study
ratn: not reported in source
Wistar Albino male rats
Comparator
Saline or water controls
Outcome group
Wound healing · Gastrointestinal
Studied dose
10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).
Source sentences
Summary
The maximal instilled volume was continuously raised until it reached the values of healthy rats
2 context sentences(design, population, supporting numbers)
Summary · context
To establish the effects of BPC 157 on the healing of rat colovesical fistulas, Wistar Albino male rats were randomly assigned to different groups.
Summary · context
BPC 157 was provided daily, perorally, in drinking water (10µg/kg, 12ml/rat/day) until sacrifice or, alternatively, 10µg/kg or 10ng/kg intraperitoneally, with the first application at 30min after surgery and the last at 24h before sacrifice.
Report a problemFND-2687563804
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with colovesical fistula, there were no signs of fecaluria after BPC‑157.
In plain wordsIn rats with a gut-bladder fistula treated with BPC‑157, there were no signs of stool in the urine.
Peptide
BPC-157
Outcome
DecreaseFecaluria
Study
ratn: not reported in source
Wistar Albino male rats
Comparator
Saline or water controls
Outcome group
Wound healing · Kidney and urinary
Studied dose
10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).
Source sentences
Summary
there were no signs of fecaluria and no defecation through the fistula, there was counteraction of advanced adhesion formation or there was an intestinal obstruction.
2 context sentences(design, population, supporting numbers)
Summary · context
To establish the effects of BPC 157 on the healing of rat colovesical fistulas, Wistar Albino male rats were randomly assigned to different groups.
Summary · context
BPC 157 was provided daily, perorally, in drinking water (10µg/kg, 12ml/rat/day) until sacrifice or, alternatively, 10µg/kg or 10ng/kg intraperitoneally, with the first application at 30min after surgery and the last at 24h before sacrifice.
Report a problemFND-2687563805
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with colovesical fistula, there was no defecation through the fistula after BPC‑157.
In plain wordsIn rats with a gut-bladder fistula treated with BPC‑157, no stool passed through the fistula.
Peptide
BPC-157
Outcome
DecreaseDefecation through the fistula
Study
ratn: not reported in source
Wistar Albino male rats
Comparator
Saline or water controls
Outcome group
Wound healing · Gastrointestinal
Studied dose
10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).
Source sentences
Summary
no defecation through the fistula, there was counteraction of advanced adhesion formation or there was an intestinal obstruction.
2 context sentences(design, population, supporting numbers)
Summary · context
To establish the effects of BPC 157 on the healing of rat colovesical fistulas, Wistar Albino male rats were randomly assigned to different groups.
Summary · context
BPC 157 was provided daily, perorally, in drinking water (10µg/kg, 12ml/rat/day) until sacrifice or, alternatively, 10µg/kg or 10ng/kg intraperitoneally, with the first application at 30min after surgery and the last at 24h before sacrifice.
Report a problemFND-2687563806
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with colovesical fistula, BPC‑157 counteracted advanced adhesion formation.
In plain wordsIn rats with a gut-bladder fistula, BPC‑157 counteracted advanced scar-like adhesions.
Peptide
BPC-157
Outcome
DecreaseAdhesion formation
Study
ratn: not reported in source
Wistar Albino male rats
Comparator
Saline or water controls
Outcome group
Wound healing · Gastrointestinal
Studied dose
10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).
Source sentences
Summary
there was counteraction of advanced adhesion formation or there was an intestinal obstruction.
2 context sentences(design, population, supporting numbers)
Summary · context
To establish the effects of BPC 157 on the healing of rat colovesical fistulas, Wistar Albino male rats were randomly assigned to different groups.
Summary · context
BPC 157 was provided daily, perorally, in drinking water (10µg/kg, 12ml/rat/day) until sacrifice or, alternatively, 10µg/kg or 10ng/kg intraperitoneally, with the first application at 30min after surgery and the last at 24h before sacrifice.
Report a problemFND-2687563807

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

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