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Study · Animal study (in vivo) · rat · 2016

8 results

Stable gastric pentadecapeptide BPC 157 heals rectovaginal fistula in rats.

Baric M, Sever AZ, Vuletic LB, Rasic Z, Sever M, Drmic D, Pavelic-Turudic T, Sucic M, Vrcic H, Seiwerth S, Sikiric P

Life sciences9 Feb 2016Cited by 15 (Europe PMC)

PMID26872976 (opens in a new tab)DOI10.1016/j.lfs.2016.02.029 (opens in a new tab)PepBankPUB-26872976
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with rectovaginal fistula, BPC‑157 given perorally or intraperitoneally rapidly improved the whole presentation.

    In plain wordsIn rats with a rectum-vagina fistula, BPC‑157 quickly improved the whole condition compared with controls.

    Peptide
    BPC-157
    Outcome
    IncreaseOverall healing of rectovaginal fistula
    Study

    ratn: not reported in source

    Comparator
    Saline or water controls
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).

    Source sentences

    Summary
    By contrast, BPC 157 given perorally or intraperitoneally, in μg- and ng-regimens rapidly improved the whole presentation, with both rectal and vaginal defects simultaneously ameliorated and eventually healed.
    1 context sentence
    Summary · context
    BPC 157 (10μg/kg or 10ng/kg) was given perorally, in drinking water (0.16μg/ml or 0.16ng/ml, 12ml/rat/day) till sacrifice, or alternatively, intraperitoneally, first application at 30min after surgery, last at 24h before sacrifice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with rectovaginal fistula, BPC‑157 ameliorated the rectal defect, which eventually healed.

    In plain wordsIn rats with a rectum-vagina fistula, BPC‑157 helped the rectal defect heal compared with controls.

    Peptide
    BPC-157
    Outcome
    DecreaseRectal defect
    Study

    ratn: not reported in source

    Comparator
    Saline or water controls
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).

    Source sentences

    Summary
    By contrast, BPC 157 given perorally or intraperitoneally, in μg- and ng-regimens rapidly improved the whole presentation, with both rectal and vaginal defects simultaneously ameliorated and eventually healed.
    1 context sentence
    Summary · context
    BPC 157 (10μg/kg or 10ng/kg) was given perorally, in drinking water (0.16μg/ml or 0.16ng/ml, 12ml/rat/day) till sacrifice, or alternatively, intraperitoneally, first application at 30min after surgery, last at 24h before sacrifice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with rectovaginal fistula, BPC‑157 ameliorated the vaginal defect, which eventually healed.

    In plain wordsIn rats with a rectum-vagina fistula, BPC‑157 helped the vaginal defect heal compared with controls.

    Peptide
    BPC-157
    Outcome
    DecreaseVaginal defect
    Study

    ratn: not reported in source

    Comparator
    Saline or water controls
    Outcome group
    Wound healing · Reproductive and sexual health
    Studied dose
    10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).

    Source sentences

    Summary
    By contrast, BPC 157 given perorally or intraperitoneally, in μg- and ng-regimens rapidly improved the whole presentation, with both rectal and vaginal defects simultaneously ameliorated and eventually healed.
    1 context sentence
    Summary · context
    BPC 157 (10μg/kg or 10ng/kg) was given perorally, in drinking water (0.16μg/ml or 0.16ng/ml, 12ml/rat/day) till sacrifice, or alternatively, intraperitoneally, first application at 30min after surgery, last at 24h before sacrifice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with rectovaginal fistula, the maximal instilled volume rose continuously until the values of healthy rats were achieved.

    In plain wordsIn rats with a rectum-vagina fistula treated with BPC‑157, the instilled volume reached the level of healthy rats.

    Peptide
    BPC-157
    Outcome
    IncreaseMaximal instilled volume
    Study

    ratn: not reported in source

    Comparator
    Saline or water controls
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).

    Source sentences

    Summary
    The maximal instilled volume was continuously raised till the values of healthy rats were achieved
    1 context sentence
    Summary · context
    BPC 157 (10μg/kg or 10ng/kg) was given perorally, in drinking water (0.16μg/ml or 0.16ng/ml, 12ml/rat/day) till sacrifice, or alternatively, intraperitoneally, first application at 30min after surgery, last at 24h before sacrifice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with rectovaginal fistula, there were no signs of defecation through the fistula after BPC‑157.

    In plain wordsIn rats with a rectum-vagina fistula treated with BPC‑157, no stool passed through the fistula.

    Peptide
    BPC-157
    Outcome
    DecreaseDefecation through the fistula
    Study

    ratn: not reported in source

    Comparator
    Saline or water controls
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).

    Source sentences

    Summary
    there were no signs of defecation through the fistula.
    1 context sentence
    Summary · context
    BPC 157 (10μg/kg or 10ng/kg) was given perorally, in drinking water (0.16μg/ml or 0.16ng/ml, 12ml/rat/day) till sacrifice, or alternatively, intraperitoneally, first application at 30min after surgery, last at 24h before sacrifice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with rectovaginal fistula, BPC‑157 counteracted advanced adhesion formation.

    In plain wordsIn rats with a rectum-vagina fistula, BPC‑157 counteracted advanced scar-like adhesions.

    Peptide
    BPC-157
    Outcome
    DecreaseAdvanced adhesion formation
    Study

    ratn: not reported in source

    Comparator
    Saline or water controls
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).

    Source sentences

    Summary
    A counteraction of advanced adhesion formation
    1 context sentence
    Summary · context
    BPC 157 (10μg/kg or 10ng/kg) was given perorally, in drinking water (0.16μg/ml or 0.16ng/ml, 12ml/rat/day) till sacrifice, or alternatively, intraperitoneally, first application at 30min after surgery, last at 24h before sacrifice.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with rectovaginal fistula, BPC‑157 counteracted intestinal obstruction.

    In plain wordsIn rats with a rectum-vagina fistula, BPC‑157 counteracted bowel blockage.

    Peptide
    BPC-157
    Outcome
    DecreaseIntestinal obstruction
    Study

    ratn: not reported in source

    Comparator
    Saline or water controls
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).

    Source sentences

    Summary
    A counteraction of advanced adhesion formation and intestinal obstruction was achieved.
    1 context sentence
    Summary · context
    BPC 157 (10μg/kg or 10ng/kg) was given perorally, in drinking water (0.16μg/ml or 0.16ng/ml, 12ml/rat/day) till sacrifice, or alternatively, intraperitoneally, first application at 30min after surgery, last at 24h before sacrifice.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with rectovaginal fistula treated with BPC‑157, microscopic improvement matched the macroscopic findings.

    In plain wordsIn rats with a rectum-vagina fistula treated with BPC‑157, microscopic improvement matched the visible improvement.

    Peptide
    BPC-157
    Outcome
    IncreaseMicroscopic healing
    Study

    ratn: not reported in source

    Comparator
    Saline or water controls
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg and 10 ng/kg · peroral in drinking water or intraperitoneal · until sacrificeAs given in this study (rat).

    Source sentences

    Summary
    Microscopic improvement was along with macroscopic findings.
    1 context sentence
    Summary · context
    BPC 157 (10μg/kg or 10ng/kg) was given perorally, in drinking water (0.16μg/ml or 0.16ng/ml, 12ml/rat/day) till sacrifice, or alternatively, intraperitoneally, first application at 30min after surgery, last at 24h before sacrifice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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Terms as the source lists them.

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