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Study · Case report or series · n = 5 · 2015

5 results

[Effectiveness and safety of pulsatile GnRH pump therapy on female patients with IHH].

Liu Z, Mao J, Wu X, Nie M, Huang B, Xu H, Wang X, Zheng J

Zhonghua yi xue za zhi1 Nov 2015Cited by 1 (Europe PMC)

PMID26813133 (opens in a new tab)PepBankPUB-26813133
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    In five women with idiopathic hypogonadotropic hypogonadism, LH rose after one week of pulsatile gonadorelin by pump.

    In plain wordsIn five women with idiopathic hypogonadotropic hypogonadism, LH rose after one week of pulsatile gonadorelin by pump.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    IncreaseLH level after one week
    Study

    n = 5

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10 µg per 90 min · pump · 1 weekAs given in this study (human).

    Measurements

    LH
    2.2 U/L
    baseline
    LH
    5.4 U/L
    after one week

    Source sentences

    Summary
    luteinizing hormone (LH) level increased from (2.2 ± 2.0) U/L to (5.4 ± 2.5) U/L (P=0.028)
    1 context sentence
    Summary · context
    In this retrospective study, five female IHH patients were recruited.
  2. 02HumanCase report or seriesEfficacy outcome

    In five women with idiopathic hypogonadotropic hypogonadism, the FSH rise after one week of pulsatile gonadorelin was not statistically significant.

    In plain wordsIn five women with idiopathic hypogonadotropic hypogonadism, FSH did not change significantly after one week of pulsatile gonadorelin.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    No significant changeFSH level after one week
    Study

    n = 5

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10 µg per 90 min · pump · 1 weekAs given in this study (human).

    Measurements

    FSH
    3.7 U/L
    baseline
    FSH
    6.3 U/L
    after one week

    Source sentences

    Summary
    follicle-stimulating hormone(FSH) level increased from (3.7 ± 2.7) U/L to(6.3 ± 1.0) U/L (P=0.162)
    1 context sentence
    Summary · context
    In this retrospective study, five female IHH patients were recruited.
  3. 03HumanCase report or seriesEfficacy outcome

    In five women with idiopathic hypogonadotropic hypogonadism, estradiol rose after one week of pulsatile gonadorelin by pump.

    In plain wordsIn five women with idiopathic hypogonadotropic hypogonadism, estradiol rose after one week of pulsatile gonadorelin by pump.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    IncreaseEstradiol level after one week
    Study

    n = 5

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10 µg per 90 min · pump · 1 weekAs given in this study (human).

    Measurements

    Estradiol
    58 pmol/L
    baseline
    Estradiol
    260 pmol/L
    after one week

    Source sentences

    Summary
    estradiol (E2) level increased from (58 ± 13) pmol/L to (260 ± 97) pmol/L (P=0.011)
    1 context sentence
    Summary · context
    In this retrospective study, five female IHH patients were recruited.
  4. 04HumanCase report or seriesEfficacy outcome

    In five women with idiopathic hypogonadotropic hypogonadism, menstrual bleeding began in four after 35-55 days of pulsatile gonadorelin, and one had none.

    In plain wordsIn five women with idiopathic hypogonadotropic hypogonadism, four had menstrual bleeding after 35-55 days of pulsatile gonadorelin and one did not.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableMenstrual bleeding
    Study

    n = 5

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg per 90 min · pump · at least 12 weeksAs given in this study (human).

    Measurements

    Patients with menstrual bleeding
    4 patients
    after 35-55 days

    Source sentences

    Summary
    Menstrual bleeding was observed in 4 patients after starting treatment for 35-55 days
    2 context sentences
    Summary · context
    No menstrual bleeding was reported in another patient.
    Summary · context
    In this retrospective study, five female IHH patients were recruited.
  5. 05HumanCase report or seriesEfficacy outcome

    In five women with idiopathic hypogonadotropic hypogonadism treated with pulsatile gonadorelin, two natural pregnancies were reported.

    In plain wordsAmong five women with idiopathic hypogonadotropic hypogonadism treated with pulsatile gonadorelin, two natural pregnancies were reported.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableNatural pregnancies
    Study

    n = 5

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg per 90 min · pump · at least 12 weeksAs given in this study (human).

    Source sentences

    Summary
    two natural pregnancies were reported.
    1 context sentence
    Summary · context
    In this retrospective study, five female IHH patients were recruited.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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