Bioactive peptide carnosin protects against lead acetate-induced hepatotoxicity by abrogation of oxidative stress in rats.

Hasanein P, Kazemian-Mahtaj A, Khodadadi I

Pharmaceutical biology25 Jan 2016Cited by 20 (Europe PMC)

PMID26808926DOI10.3109/13880209.2015.1104700PepBankPUB-26808926

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine decreased hepatic MDA to 4 ± 0.08 nmol/mg.
In plain wordsIn rats exposed to lead, carnosine reduced liver MDA compared with the lead group.
Peptide
L-carnosine
Outcome
DecreaseHepatic MDA
Study
ratn: not reported in source
Lead acetate-induced hepatotoxicity
Comparator
Lead group
Outcome group
Oxidative stress · Liver
Studied dose
10 mg/kg daily · oral gavage · 8 weeksAs given in this study (rat).
Measurements
MDA
4 nmol/mg
carnosine in lead group
Source sentences
Summary
Carnosine treatment decreased MDA (4 ± 0.08 nmol/mg), whereas it increased the contents of total thiol (3.25 ± 0.04 μmol/g) and TAC (3.44 ± 0.32 μmol/g) in the lead group.
2 context sentences(design, population, supporting numbers)
Summary · context
Objectives We investigated the effects of carnosine on lead-induced hepatotoxicity and oxidative stress in rats.
Summary · context
Materials and methods Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or daily oral gavage of carnosine (10 mg/kg) for 8 weeks.
Report a problemFND-2680892601
02AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine increased total thiol content to 3.25 ± 0.04 μmol/g.
In plain wordsIn rats exposed to lead, carnosine increased liver total thiol compared with the lead group.
Peptide
L-carnosine
Outcome
IncreaseTotal thiol
Study
ratn: not reported in source
Lead acetate-induced hepatotoxicity
Comparator
Lead group
Outcome group
Oxidative stress · Liver
Studied dose
10 mg/kg daily · oral gavage · 8 weeksAs given in this study (rat).
Measurements
Total thiol
3.25 μmol/g
carnosine in lead group
Source sentences
Summary
Carnosine treatment decreased MDA (4 ± 0.08 nmol/mg), whereas it increased the contents of total thiol (3.25 ± 0.04 μmol/g) and TAC (3.44 ± 0.32 μmol/g) in the lead group.
2 context sentences(design, population, supporting numbers)
Summary · context
Objectives We investigated the effects of carnosine on lead-induced hepatotoxicity and oxidative stress in rats.
Summary · context
Materials and methods Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or daily oral gavage of carnosine (10 mg/kg) for 8 weeks.
Report a problemFND-2680892602
03AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine increased TAC to 3.44 ± 0.32 μmol/g.
In plain wordsIn rats exposed to lead, carnosine increased liver antioxidant capacity compared with the lead group.
Peptide
L-carnosine
Outcome
IncreaseTotal antioxidant capacity
Study
ratn: not reported in source
Lead acetate-induced hepatotoxicity
Comparator
Lead group
Outcome group
Oxidative stress · Liver
Studied dose
10 mg/kg daily · oral gavage · 8 weeksAs given in this study (rat).
Measurements
TAC
3.44 μmol/g
carnosine in lead group
Source sentences
Summary
Carnosine treatment decreased MDA (4 ± 0.08 nmol/mg), whereas it increased the contents of total thiol (3.25 ± 0.04 μmol/g) and TAC (3.44 ± 0.32 μmol/g) in the lead group.
2 context sentences(design, population, supporting numbers)
Summary · context
Objectives We investigated the effects of carnosine on lead-induced hepatotoxicity and oxidative stress in rats.
Summary · context
Materials and methods Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or daily oral gavage of carnosine (10 mg/kg) for 8 weeks.
Report a problemFND-2680892603
04AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented decreased body weight.
In plain wordsIn rats exposed to lead, carnosine prevented body weight loss compared with the lead group.
Peptide
L-carnosine
Outcome
IncreaseBody weight
Study
ratn: not reported in source
Lead acetate-induced hepatotoxicity
Comparator
Lead group
Outcome group
Body weight · Metabolic and weight
Studied dose
10 mg/kg daily · oral gavage · 8 weeksAs given in this study (rat).
Source sentences
Summary
Carnosine also prevented the decreased body weight (p < 0.001), albumin (p < 0.05) and total protein levels (p < 0.001) and increased liver weight (p < 0.05) and activates of hepatic enzymes (p's < 0.001) (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydro…
2 context sentences(design, population, supporting numbers)
Summary · context
Objectives We investigated the effects of carnosine on lead-induced hepatotoxicity and oxidative stress in rats.
Summary · context
Materials and methods Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or daily oral gavage of carnosine (10 mg/kg) for 8 weeks.
Report a problemFND-2680892604
05AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented decreased albumin levels.
In plain wordsIn rats exposed to lead, carnosine prevented falling albumin levels compared with the lead group.
Peptide
L-carnosine
Outcome
IncreaseAlbumin
Study
ratn: not reported in source
Lead acetate-induced hepatotoxicity
Comparator
Lead group
Outcome group
Liver fat and liver function · Liver
Studied dose
10 mg/kg daily · oral gavage · 8 weeksAs given in this study (rat).
Source sentences
Summary
Carnosine also prevented the decreased body weight (p < 0.001), albumin (p < 0.05) and total protein levels (p < 0.001) and increased liver weight (p < 0.05) and activates of hepatic enzymes (p's < 0.001) (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydro…
2 context sentences(design, population, supporting numbers)
Summary · context
Objectives We investigated the effects of carnosine on lead-induced hepatotoxicity and oxidative stress in rats.
Summary · context
Materials and methods Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or daily oral gavage of carnosine (10 mg/kg) for 8 weeks.
Report a problemFND-2680892605
06AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented decreased total protein levels.
In plain wordsIn rats exposed to lead, carnosine prevented falling total protein levels compared with the lead group.
Peptide
L-carnosine
Outcome
IncreaseTotal protein
Study
ratn: not reported in source
Lead acetate-induced hepatotoxicity
Comparator
Lead group
Outcome group
Liver fat and liver function · Liver
Studied dose
10 mg/kg daily · oral gavage · 8 weeksAs given in this study (rat).
Source sentences
Summary
Carnosine also prevented the decreased body weight (p < 0.001), albumin (p < 0.05) and total protein levels (p < 0.001) and increased liver weight (p < 0.05) and activates of hepatic enzymes (p's < 0.001) (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydro…
2 context sentences(design, population, supporting numbers)
Summary · context
Objectives We investigated the effects of carnosine on lead-induced hepatotoxicity and oxidative stress in rats.
Summary · context
Materials and methods Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or daily oral gavage of carnosine (10 mg/kg) for 8 weeks.
Report a problemFND-2680892606
07AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented increased liver weight.
In plain wordsIn rats exposed to lead, carnosine prevented increased liver weight compared with the lead group.
Peptide
L-carnosine
Outcome
DecreaseLiver weight increase
Study
ratn: not reported in source
Lead acetate-induced hepatotoxicity
Comparator
Lead group
Outcome group
Liver fat and liver function · Liver
Studied dose
10 mg/kg daily · oral gavage · 8 weeksAs given in this study (rat).
Source sentences
Summary
Carnosine also prevented the decreased body weight (p < 0.001), albumin (p < 0.05) and total protein levels (p < 0.001) and increased liver weight (p < 0.05) and activates of hepatic enzymes (p's < 0.001) (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydro…
2 context sentences(design, population, supporting numbers)
Summary · context
Objectives We investigated the effects of carnosine on lead-induced hepatotoxicity and oxidative stress in rats.
Summary · context
Materials and methods Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or daily oral gavage of carnosine (10 mg/kg) for 8 weeks.
Report a problemFND-2680892607
08AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented increased alanine aminotransferase activity.
In plain wordsIn rats exposed to lead, carnosine prevented increased alanine aminotransferase activity compared with the lead group.
Peptide
L-carnosine
Outcome
DecreaseAlanine aminotransferase activity
Study
ratn: not reported in source
Lead acetate-induced hepatotoxicity
Comparator
Lead group
Outcome group
Liver fat and liver function · Liver
Studied dose
10 mg/kg daily · oral gavage · 8 weeksAs given in this study (rat).
Source sentences
Summary
Carnosine also prevented the decreased body weight (p < 0.001), albumin (p < 0.05) and total protein levels (p < 0.001) and increased liver weight (p < 0.05) and activates of hepatic enzymes (p's < 0.001) (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydro…
2 context sentences(design, population, supporting numbers)
Summary · context
Objectives We investigated the effects of carnosine on lead-induced hepatotoxicity and oxidative stress in rats.
Summary · context
Materials and methods Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or daily oral gavage of carnosine (10 mg/kg) for 8 weeks.
Report a problemFND-2680892608
09AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented increased aspartate aminotransferase activity.
In plain wordsIn rats exposed to lead, carnosine prevented increased aspartate aminotransferase activity compared with the lead group.
Peptide
L-carnosine
Outcome
DecreaseAspartate aminotransferase activity
Study
ratn: not reported in source
Lead acetate-induced hepatotoxicity
Comparator
Lead group
Outcome group
Liver fat and liver function · Liver
Studied dose
10 mg/kg daily · oral gavage · 8 weeksAs given in this study (rat).
Source sentences
Summary
Carnosine also prevented the decreased body weight (p < 0.001), albumin (p < 0.05) and total protein levels (p < 0.001) and increased liver weight (p < 0.05) and activates of hepatic enzymes (p's < 0.001) (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydro…
2 context sentences(design, population, supporting numbers)
Summary · context
Objectives We investigated the effects of carnosine on lead-induced hepatotoxicity and oxidative stress in rats.
Summary · context
Materials and methods Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or daily oral gavage of carnosine (10 mg/kg) for 8 weeks.
Report a problemFND-2680892609
10AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented increased alkaline phosphatase activity.
In plain wordsIn rats exposed to lead, carnosine prevented increased alkaline phosphatase activity compared with the lead group.
Peptide
L-carnosine
Outcome
DecreaseAlkaline phosphatase activity
Study
ratn: not reported in source
Lead acetate-induced hepatotoxicity
Comparator
Lead group
Outcome group
Liver fat and liver function · Liver
Studied dose
10 mg/kg daily · oral gavage · 8 weeksAs given in this study (rat).
Source sentences
Summary
Carnosine also prevented the decreased body weight (p < 0.001), albumin (p < 0.05) and total protein levels (p < 0.001) and increased liver weight (p < 0.05) and activates of hepatic enzymes (p's < 0.001) (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydro…
2 context sentences(design, population, supporting numbers)
Summary · context
Objectives We investigated the effects of carnosine on lead-induced hepatotoxicity and oxidative stress in rats.
Summary · context
Materials and methods Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or daily oral gavage of carnosine (10 mg/kg) for 8 weeks.
Report a problemFND-2680892610
11AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented increased lactate dehydrogenase activity.
In plain wordsIn rats exposed to lead, carnosine prevented increased lactate dehydrogenase activity compared with the lead group.
Peptide
L-carnosine
Outcome
DecreaseLactate dehydrogenase activity
Study
ratn: not reported in source
Lead acetate-induced hepatotoxicity
Comparator
Lead group
Outcome group
Liver fat and liver function · Liver
Studied dose
10 mg/kg daily · oral gavage · 8 weeksAs given in this study (rat).
Source sentences
Summary
Carnosine also prevented the decreased body weight (p < 0.001), albumin (p < 0.05) and total protein levels (p < 0.001) and increased liver weight (p < 0.05) and activates of hepatic enzymes (p's < 0.001) (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydro…
2 context sentences(design, population, supporting numbers)
Summary · context
Objectives We investigated the effects of carnosine on lead-induced hepatotoxicity and oxidative stress in rats.
Summary · context
Materials and methods Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or daily oral gavage of carnosine (10 mg/kg) for 8 weeks.
Report a problemFND-2680892611
12AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine decreased liver necrosis.
In plain wordsIn rats exposed to lead, carnosine reduced liver tissue death compared with the lead group.
Peptide
L-carnosine
Outcome
DecreaseLiver necrosis
Study
ratn: not reported in source
Lead acetate-induced hepatotoxicity
Comparator
Lead group
Outcome group
Liver fat and liver function · Liver
Studied dose
10 mg/kg daily · oral gavage · 8 weeksAs given in this study (rat).
Source sentences
Summary
Furthermore, histopathological study showed that carnosine attenuates liver damage by decreasing necrosis and infiltration of inflammatory cells.
2 context sentences(design, population, supporting numbers)
Summary · context
Objectives We investigated the effects of carnosine on lead-induced hepatotoxicity and oxidative stress in rats.
Summary · context
Materials and methods Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or daily oral gavage of carnosine (10 mg/kg) for 8 weeks.
Report a problemFND-2680892612
13AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine decreased inflammatory cell infiltration in liver tissue.
In plain wordsIn rats exposed to lead, carnosine reduced inflammatory cells entering liver tissue compared with the lead group.
Peptide
L-carnosine
Outcome
DecreaseInflammatory cell infiltration
Study
ratn: not reported in source
Lead acetate-induced hepatotoxicity
Comparator
Lead group
Outcome group
Inflammation markers · Liver
Studied dose
10 mg/kg daily · oral gavage · 8 weeksAs given in this study (rat).
Source sentences
Summary
Furthermore, histopathological study showed that carnosine attenuates liver damage by decreasing necrosis and infiltration of inflammatory cells.
2 context sentences(design, population, supporting numbers)
Summary · context
Objectives We investigated the effects of carnosine on lead-induced hepatotoxicity and oxidative stress in rats.
Summary · context
Materials and methods Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or daily oral gavage of carnosine (10 mg/kg) for 8 weeks.
Report a problemFND-2680892613

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Bioactive peptide carnosin protects against lead acetate-induced hepatotoxicity by abrogation of oxidative stress in rats.

Summary

Results from this study13

Version history

Subjects

Publication types

MeSH terms

Keywords