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Study · Animal study (in vivo) · rat · 2016

20 results

Aging-induced changes in brain regional serotonin receptor binding: Effect of Carnosine.

Banerjee S, Poddar MK

Neuroscience22 Jan 2016Cited by 9 (Europe PMC)

PMID26808776 (opens in a new tab)DOI10.1016/j.neuroscience.2016.01.032 (opens in a new tab)PepBankPUB-26808776
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study20

20 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In aged rats, carnosine attenuated altered serotonin receptor binding across brain regions toward young-rat values.

    In plain wordsIn aged rats, carnosine moved serotonin binding across brain regions toward young-rat values.

    Peptide
    L-carnosine
    Outcome
    MixedReceptor binding at 24 months across brain regions
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The aging-induced changes in [(3)H]-5-HT receptor binding with carnosine (2.0 μg/kg/day, intrathecally, for 21 consecutive days) attenuated in (a) 24-month-aged rats irrespective of the brain regions with the attenuation of its Bmax except hypothalamus where both Bmax and KD were significantly attenuated
    2 context sentences
    Summary · context
    and restored toward the [(3)H]-5-HT receptor binding that observed in 4-month-young rats.
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In aged rats, carnosine attenuated altered serotonin receptor Bmax across brain regions.

    In plain wordsIn aged rats, carnosine reduced age-related abnormalities in serotonin receptor binding capacity across brain regions.

    Peptide
    L-carnosine
    Outcome
    MixedBmax at 24 months across brain regions
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The aging-induced changes in [(3)H]-5-HT receptor binding with carnosine (2.0 μg/kg/day, intrathecally, for 21 consecutive days) attenuated in (a) 24-month-aged rats irrespective of the brain regions with the attenuation of its Bmax except hypothalamus where both Bmax and KD were significantly attenuated
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In aged rats, carnosine significantly attenuated altered hypothalamic serotonin receptor KD.

    In plain wordsIn aged rats, carnosine reduced age-related abnormalities in hypothalamic serotonin receptor KD.

    Peptide
    L-carnosine
    Outcome
    MixedHypothalamic KD at 24 months
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The aging-induced changes in [(3)H]-5-HT receptor binding with carnosine (2.0 μg/kg/day, intrathecally, for 21 consecutive days) attenuated in (a) 24-month-aged rats irrespective of the brain regions with the attenuation of its Bmax except hypothalamus where both Bmax and KD were significantly attenuated
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In aging rats, carnosine attenuated altered hippocampal serotonin receptor binding toward young-rat values.

    In plain wordsIn aging rats, carnosine moved hippocampal serotonin binding toward young-rat values.

    Peptide
    L-carnosine
    Outcome
    MixedHippocampal receptor binding at 18 months
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    (b) hippocampus and hypothalamus of 18-month-aged rats with the attenuation of its Bmax, and restored toward the [(3)H]-5-HT receptor binding that observed in 4-month-young rats.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In aging rats, carnosine attenuated altered hypothalamic serotonin receptor binding toward young-rat values.

    In plain wordsIn aging rats, carnosine moved hypothalamic serotonin binding toward young-rat values.

    Peptide
    L-carnosine
    Outcome
    MixedHypothalamic receptor binding at 18 months
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    (b) hippocampus and hypothalamus of 18-month-aged rats with the attenuation of its Bmax, and restored toward the [(3)H]-5-HT receptor binding that observed in 4-month-young rats.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In aging rats, carnosine attenuated altered hippocampal serotonin receptor Bmax.

    In plain wordsIn aging rats, carnosine reduced age-related abnormalities in hippocampal serotonin receptor binding capacity.

    Peptide
    L-carnosine
    Outcome
    MixedHippocampal Bmax at 18 months
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    (b) hippocampus and hypothalamus of 18-month-aged rats with the attenuation of its Bmax, and restored toward the [(3)H]-5-HT receptor binding that observed in 4-month-young rats.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In aging rats, carnosine attenuated altered hypothalamic serotonin receptor Bmax.

    In plain wordsIn aging rats, carnosine reduced age-related abnormalities in hypothalamic serotonin receptor binding capacity.

    Peptide
    L-carnosine
    Outcome
    MixedHypothalamic Bmax at 18 months
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    (b) hippocampus and hypothalamus of 18-month-aged rats with the attenuation of its Bmax, and restored toward the [(3)H]-5-HT receptor binding that observed in 4-month-young rats.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In aging rats, carnosine promoted the decrease in pons-medullary serotonin receptor binding.

    In plain wordsIn aging rats, carnosine further decreased serotonin binding in the pons and medulla.

    Peptide
    L-carnosine
    Outcome
    DecreasePons-medullary receptor binding at 18 months
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The decrease in pons-medullary [(3)H]-5-HT binding including its Bmax of 18-month-aged rats was promoted with carnosine without any significant change in its cerebral cortex.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In aging rats, carnosine promoted the decrease in pons-medullary serotonin receptor Bmax.

    In plain wordsIn aging rats, carnosine further decreased serotonin receptor binding capacity in the pons and medulla.

    Peptide
    L-carnosine
    Outcome
    DecreasePons-medullary Bmax at 18 months
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The decrease in pons-medullary [(3)H]-5-HT binding including its Bmax of 18-month-aged rats was promoted with carnosine without any significant change in its cerebral cortex.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In aging rats, carnosine did not significantly change cortical serotonin receptor binding.

    In plain wordsIn aging rats, carnosine did not significantly change serotonin binding in the cerebral cortex.

    Peptide
    L-carnosine
    Outcome
    No significant changeCortical receptor binding at 18 months
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The decrease in pons-medullary [(3)H]-5-HT binding including its Bmax of 18-month-aged rats was promoted with carnosine without any significant change in its cerebral cortex.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine increased cortical serotonin receptor binding.

    In plain wordsIn young rats, carnosine increased serotonin binding in the cerebral cortex.

    Peptide
    L-carnosine
    Outcome
    IncreaseCortical receptor binding in young rats
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The [(3)H]-5-HT receptor binding with the same dosages of carnosine in 4-month-young rats (a) increased in the cerebral cortex and hippocampus with the increase in their only Bmax whereas (b) decreased in hypothalamus and pons-medulla with a decrease in their both Bmax and KD.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine increased hippocampal serotonin receptor binding.

    In plain wordsIn young rats, carnosine increased serotonin binding in the hippocampus.

    Peptide
    L-carnosine
    Outcome
    IncreaseHippocampal receptor binding in young rats
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The [(3)H]-5-HT receptor binding with the same dosages of carnosine in 4-month-young rats (a) increased in the cerebral cortex and hippocampus with the increase in their only Bmax whereas (b) decreased in hypothalamus and pons-medulla with a decrease in their both Bmax and KD.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine increased cortical serotonin receptor Bmax.

    In plain wordsIn young rats, carnosine increased serotonin receptor binding capacity in the cerebral cortex.

    Peptide
    L-carnosine
    Outcome
    IncreaseCortical Bmax in young rats
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The [(3)H]-5-HT receptor binding with the same dosages of carnosine in 4-month-young rats (a) increased in the cerebral cortex and hippocampus with the increase in their only Bmax whereas (b) decreased in hypothalamus and pons-medulla with a decrease in their both Bmax and KD.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine increased hippocampal serotonin receptor Bmax.

    In plain wordsIn young rats, carnosine increased serotonin receptor binding capacity in the hippocampus.

    Peptide
    L-carnosine
    Outcome
    IncreaseHippocampal Bmax in young rats
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The [(3)H]-5-HT receptor binding with the same dosages of carnosine in 4-month-young rats (a) increased in the cerebral cortex and hippocampus with the increase in their only Bmax whereas (b) decreased in hypothalamus and pons-medulla with a decrease in their both Bmax and KD.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  15. 15AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine decreased hypothalamic serotonin receptor binding.

    In plain wordsIn young rats, carnosine decreased serotonin binding in the hypothalamus.

    Peptide
    L-carnosine
    Outcome
    DecreaseHypothalamic receptor binding in young rats
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The [(3)H]-5-HT receptor binding with the same dosages of carnosine in 4-month-young rats (a) increased in the cerebral cortex and hippocampus with the increase in their only Bmax whereas (b) decreased in hypothalamus and pons-medulla with a decrease in their both Bmax and KD.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  16. 16AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine decreased pons-medullary serotonin receptor binding.

    In plain wordsIn young rats, carnosine decreased serotonin binding in the pons and medulla.

    Peptide
    L-carnosine
    Outcome
    DecreasePons-medullary receptor binding in young rats
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The [(3)H]-5-HT receptor binding with the same dosages of carnosine in 4-month-young rats (a) increased in the cerebral cortex and hippocampus with the increase in their only Bmax whereas (b) decreased in hypothalamus and pons-medulla with a decrease in their both Bmax and KD.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  17. 17AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine decreased hypothalamic serotonin receptor Bmax.

    In plain wordsIn young rats, carnosine decreased serotonin receptor binding capacity in the hypothalamus.

    Peptide
    L-carnosine
    Outcome
    DecreaseHypothalamic Bmax in young rats
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The [(3)H]-5-HT receptor binding with the same dosages of carnosine in 4-month-young rats (a) increased in the cerebral cortex and hippocampus with the increase in their only Bmax whereas (b) decreased in hypothalamus and pons-medulla with a decrease in their both Bmax and KD.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  18. 18AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine decreased pons-medullary serotonin receptor Bmax.

    In plain wordsIn young rats, carnosine decreased serotonin receptor binding capacity in the pons and medulla.

    Peptide
    L-carnosine
    Outcome
    DecreasePons-medullary Bmax in young rats
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The [(3)H]-5-HT receptor binding with the same dosages of carnosine in 4-month-young rats (a) increased in the cerebral cortex and hippocampus with the increase in their only Bmax whereas (b) decreased in hypothalamus and pons-medulla with a decrease in their both Bmax and KD.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  19. 19AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine decreased hypothalamic serotonin receptor KD.

    In plain wordsIn young rats, carnosine decreased the serotonin receptor KD in the hypothalamus.

    Peptide
    L-carnosine
    Outcome
    DecreaseHypothalamic KD in young rats
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The [(3)H]-5-HT receptor binding with the same dosages of carnosine in 4-month-young rats (a) increased in the cerebral cortex and hippocampus with the increase in their only Bmax whereas (b) decreased in hypothalamus and pons-medulla with a decrease in their both Bmax and KD.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.
  20. 20AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine decreased pons-medullary serotonin receptor KD.

    In plain wordsIn young rats, carnosine decreased the serotonin receptor KD in the pons and medulla.

    Peptide
    L-carnosine
    Outcome
    DecreasePons-medullary KD in young rats
    Study

    ratn: not reported in source

    Rat brain aging model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 μg/kg/day · intrathecal · 21 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The [(3)H]-5-HT receptor binding with the same dosages of carnosine in 4-month-young rats (a) increased in the cerebral cortex and hippocampus with the increase in their only Bmax whereas (b) decreased in hypothalamus and pons-medulla with a decrease in their both Bmax and KD.
    1 context sentence
    Summary · context
    In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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