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Study · Ex vivo tissue · mouse · 2017

5 results

Pramlintide Antagonizes Beta Amyloid (Aβ)- and Human Amylin-Induced Depression of Hippocampal Long-Term Potentiation.

Kimura R, MacTavish D, Yang J, Westaway D, Jhamandas JH

Molecular neurobiology15 Jan 2016Cited by 22 (Europe PMC)

PMID26768593 (opens in a new tab)DOI10.1007/s12035-016-9684-x (opens in a new tab)PepBankPUB-26768593
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In mouse hippocampal slices, pramlintide blocked Aβ-induced reduction of long-term potentiation.

    In plain wordsIn lab tests, pramlintide preserved synaptic potentiation compared with Aβ alone.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseAβ-induced LTP depression
    Study

    mousen: not reported in source

    hippocampal brain slices
    Comparator
    Aβ alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    250 nMAs given in this study (mouse).

    Source sentences

    Summary
    Pre-application of pramlintide (250 nM) blocked Aβ- and human amylin-induced reduction of LTP without affecting baseline transmission or LTP.
    2 context sentences
    Summary · context
    In this study, we examined the effects of pramlintide on Aβ1-42 and human amylin-evoked depression of long-term potentiation (LTP) at Schaeffer collateral-CA1 hippocampal synapses.
    Summary · context
    In mouse hippocampal brain slices, field excitatory postsynaptic potentials (fEPSPs) were recorded from the stratum radiatum layer of the CA1 area in response to electrical stimulation of Schaeffer collateral afferents and LTP induced by 3-theta-burst stimulation (TBS) protocol.
  2. 02LabEx vivo tissueEfficacy outcome

    In mouse hippocampal slices, pramlintide blocked human amylin-induced reduction of long-term potentiation.

    In plain wordsIn lab tests, pramlintide preserved synaptic potentiation compared with human amylin alone.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseHuman amylin-induced LTP depression
    Study

    mousen: not reported in source

    hippocampal brain slices
    Comparator
    human amylin alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    250 nMAs given in this study (mouse).

    Source sentences

    Summary
    Pre-application of pramlintide (250 nM) blocked Aβ- and human amylin-induced reduction of LTP without affecting baseline transmission or LTP.
    2 context sentences
    Summary · context
    In this study, we examined the effects of pramlintide on Aβ1-42 and human amylin-evoked depression of long-term potentiation (LTP) at Schaeffer collateral-CA1 hippocampal synapses.
    Summary · context
    In mouse hippocampal brain slices, field excitatory postsynaptic potentials (fEPSPs) were recorded from the stratum radiatum layer of the CA1 area in response to electrical stimulation of Schaeffer collateral afferents and LTP induced by 3-theta-burst stimulation (TBS) protocol.
  3. 03LabEx vivo tissueActivity measurement

    In mouse hippocampal slices, pramlintide did not affect baseline transmission.

    In plain wordsIn lab tests, pramlintide did not change baseline nerve transmission.

    Peptide
    Pramlintide (Symlin)
    Outcome
    No significant changeBaseline transmission
    Study

    mousen: not reported in source

    hippocampal brain slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    250 nMAs given in this study (mouse).

    Source sentences

    Summary
    Pre-application of pramlintide (250 nM) blocked Aβ- and human amylin-induced reduction of LTP without affecting baseline transmission or LTP.
    2 context sentences
    Summary · context
    In this study, we examined the effects of pramlintide on Aβ1-42 and human amylin-evoked depression of long-term potentiation (LTP) at Schaeffer collateral-CA1 hippocampal synapses.
    Summary · context
    In mouse hippocampal brain slices, field excitatory postsynaptic potentials (fEPSPs) were recorded from the stratum radiatum layer of the CA1 area in response to electrical stimulation of Schaeffer collateral afferents and LTP induced by 3-theta-burst stimulation (TBS) protocol.
  4. 04LabEx vivo tissueActivity measurement

    In mouse hippocampal slices, pramlintide did not affect baseline long-term potentiation.

    In plain wordsIn lab tests, pramlintide did not change baseline synaptic potentiation.

    Peptide
    Pramlintide (Symlin)
    Outcome
    No significant changeBaseline LTP
    Study

    mousen: not reported in source

    hippocampal brain slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    250 nMAs given in this study (mouse).

    Source sentences

    Summary
    Pre-application of pramlintide (250 nM) blocked Aβ- and human amylin-induced reduction of LTP without affecting baseline transmission or LTP.
    2 context sentences
    Summary · context
    In this study, we examined the effects of pramlintide on Aβ1-42 and human amylin-evoked depression of long-term potentiation (LTP) at Schaeffer collateral-CA1 hippocampal synapses.
    Summary · context
    In mouse hippocampal brain slices, field excitatory postsynaptic potentials (fEPSPs) were recorded from the stratum radiatum layer of the CA1 area in response to electrical stimulation of Schaeffer collateral afferents and LTP induced by 3-theta-burst stimulation (TBS) protocol.
  5. 05LabEx vivo tissueActivity measurement

    In TgCRND8 mouse hippocampal tissue, pramlintide enhanced basal long-term potentiation.

    In plain wordsIn lab tests, pramlintide increased synaptic potentiation in tissue from TgCRND8 mice.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseBasal LTP in TgCRND8 tissue
    Study

    mousen: not reported in source

    TgCRND8 hippocampal tissue
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In TgCRND8 mice, basal LTP is enhanced by application of pramlintide.
    3 context sentences
    Summary · context
    We also examined the effects of pramlintide on LTP in transgenic mice (TgCRND8) that over-express amyloid precursor protein.
    Summary · context
    In this study, we examined the effects of pramlintide on Aβ1-42 and human amylin-evoked depression of long-term potentiation (LTP) at Schaeffer collateral-CA1 hippocampal synapses.
    Summary · context
    In mouse hippocampal brain slices, field excitatory postsynaptic potentials (fEPSPs) were recorded from the stratum radiatum layer of the CA1 area in response to electrical stimulation of Schaeffer collateral afferents and LTP induced by 3-theta-burst stimulation (TBS) protocol.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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