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Study · Animal study (in vivo) · mouse · 2015

15 results

Exendin-4 attenuates renal tubular injury by decreasing oxidative stress and inflammation in streptozotocin-induced diabetic mice.

Sancar-Bas S, Gezginci-Oktayoglu S, Bolkent S

Growth factors (Chur, Switzerland)1 Jan 2015Cited by 60 (Europe PMC)

PMID26728502 (opens in a new tab)DOI10.3109/08977194.2015.1125349 (opens in a new tab)PepBankPUB-26728502
Publisher pagePubMedAsk about this study
Jump to 15 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 decreased renal tubular injury.

    In plain wordsIn mice with diabetes, exendin‑4 reduced kidney tubule injury compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseRenal tubular injury
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    In our diabetic model, we observed renal injury mainly in tubular area rather than glomeruli and exendin-4 decreased tubular injury with its glucose lowering effect.
    1 context sentence
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 lowered glucose.

    In plain wordsIn mice with diabetes, exendin‑4 reduced blood sugar compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseBlood glucose
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    In our diabetic model, we observed renal injury mainly in tubular area rather than glomeruli and exendin-4 decreased tubular injury with its glucose lowering effect.
    1 context sentence
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 reduced PCNA-positive renal tubular cells.

    In plain wordsIn mice with diabetes, exendin‑4 reduced kidney tubule cells positive for PCNA compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreasePCNA-positive tubular cells
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Besides, PCNA positive tubular cells, activities of LDH and Na(+)-K(+)-ATPase were also significantly declined by the administration of exendin-4.
    1 context sentence
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 reduced LDH activity.

    In plain wordsIn mice with diabetes, exendin‑4 reduced LDH enzyme activity compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseLDH activity
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Besides, PCNA positive tubular cells, activities of LDH and Na(+)-K(+)-ATPase were also significantly declined by the administration of exendin-4.
    1 context sentence
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 reduced Na(+)-K(+)-ATPase activity.

    In plain wordsIn mice with diabetes, exendin‑4 reduced sodium-potassium pump activity compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseNa(+)-K(+)-ATPase activity
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Besides, PCNA positive tubular cells, activities of LDH and Na(+)-K(+)-ATPase were also significantly declined by the administration of exendin-4.
    1 context sentence
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 reduced reactive oxygen species levels.

    In plain wordsIn mice with diabetes, exendin‑4 reduced reactive oxygen species levels compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseReactive oxygen species
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, exendin-4 attenuated the levels of ROS, MDA, 8-OHdG, proinflammatory cytokines (TNF-α, IL-1β), chemokine MCP-1, ICAM-1, and fibrosis-related molecules (transforming growth factor β1 and fibronectin).
    1 context sentence
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 reduced MDA levels.

    In plain wordsIn mice with diabetes, exendin‑4 reduced MDA levels compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMDA
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, exendin-4 attenuated the levels of ROS, MDA, 8-OHdG, proinflammatory cytokines (TNF-α, IL-1β), chemokine MCP-1, ICAM-1, and fibrosis-related molecules (transforming growth factor β1 and fibronectin).
    1 context sentence
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 reduced 8-OHdG levels.

    In plain wordsIn mice with diabetes, exendin‑4 reduced 8-OHdG levels compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    Decrease8-OHdG
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, exendin-4 attenuated the levels of ROS, MDA, 8-OHdG, proinflammatory cytokines (TNF-α, IL-1β), chemokine MCP-1, ICAM-1, and fibrosis-related molecules (transforming growth factor β1 and fibronectin).
    1 context sentence
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 reduced TNF-alpha levels.

    In plain wordsIn mice with diabetes, exendin‑4 reduced TNF-alpha levels compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseTNF-alpha
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, exendin-4 attenuated the levels of ROS, MDA, 8-OHdG, proinflammatory cytokines (TNF-α, IL-1β), chemokine MCP-1, ICAM-1, and fibrosis-related molecules (transforming growth factor β1 and fibronectin).
    1 context sentence
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 reduced IL-1beta levels.

    In plain wordsIn mice with diabetes, exendin‑4 reduced IL-1beta levels compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseIL-1beta
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, exendin-4 attenuated the levels of ROS, MDA, 8-OHdG, proinflammatory cytokines (TNF-α, IL-1β), chemokine MCP-1, ICAM-1, and fibrosis-related molecules (transforming growth factor β1 and fibronectin).
    1 context sentence
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 reduced MCP-1 levels and production in renal tubular cells.

    In plain wordsIn mice with diabetes, exendin‑4 reduced MCP-1 levels and production in kidney tubule cells compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMCP-1
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, exendin-4 attenuated the levels of ROS, MDA, 8-OHdG, proinflammatory cytokines (TNF-α, IL-1β), chemokine MCP-1, ICAM-1, and fibrosis-related molecules (transforming growth factor β1 and fibronectin).
    2 context sentences
    Summary · context
    In consistent with reducing tubular injury, macrophage infiltration and both MCP-1 and ICAM-1 production in tubular cells were decreased.
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 reduced ICAM-1 levels and production in renal tubular cells.

    In plain wordsIn mice with diabetes, exendin‑4 reduced ICAM-1 levels and production in kidney tubule cells compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseICAM-1
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, exendin-4 attenuated the levels of ROS, MDA, 8-OHdG, proinflammatory cytokines (TNF-α, IL-1β), chemokine MCP-1, ICAM-1, and fibrosis-related molecules (transforming growth factor β1 and fibronectin).
    2 context sentences
    Summary · context
    In consistent with reducing tubular injury, macrophage infiltration and both MCP-1 and ICAM-1 production in tubular cells were decreased.
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 reduced transforming growth factor beta1 levels.

    In plain wordsIn mice with diabetes, exendin‑4 reduced transforming growth factor beta1 levels compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseTransforming growth factor beta1
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, exendin-4 attenuated the levels of ROS, MDA, 8-OHdG, proinflammatory cytokines (TNF-α, IL-1β), chemokine MCP-1, ICAM-1, and fibrosis-related molecules (transforming growth factor β1 and fibronectin).
    1 context sentence
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 reduced fibronectin levels.

    In plain wordsIn mice with diabetes, exendin‑4 reduced fibronectin levels compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseFibronectin
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, exendin-4 attenuated the levels of ROS, MDA, 8-OHdG, proinflammatory cytokines (TNF-α, IL-1β), chemokine MCP-1, ICAM-1, and fibrosis-related molecules (transforming growth factor β1 and fibronectin).
    1 context sentence
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.
  15. 15AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, exendin‑4 reduced macrophage infiltration.

    In plain wordsIn mice with diabetes, exendin‑4 reduced macrophage infiltration compared with diabetic mice without exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMacrophage infiltration
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes in male BALB/c mice
    Comparator
    Diabetic mice without exendin-4
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    3 μg/kgAs given in this study (mouse).

    Source sentences

    Summary
    In consistent with reducing tubular injury, macrophage infiltration and both MCP-1 and ICAM-1 production in tubular cells were decreased.
    1 context sentence
    Summary · context
    BALB/c male mice were divided into four groups: non-diabetic, non-diabetic + exendin-4 (3 μg/kg), diabetic and diabetic + exendin-4.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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