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Study · Animal study (in vivo) · mouse · 2016

6 results

SS31, a Small Molecule Antioxidant Peptide, Attenuates β-Amyloid Elevation, Mitochondrial/Synaptic Deterioration and Cognitive Deficit in SAMP8 Mice.

Jia YL, Sun SJ, Chen JH, Jia Q, Huo TT, Chu LF, Bai JT, Yu YJ, Yan XX, Wang JH

Current Alzheimer research1 Jan 2016Cited by 24 (Europe PMC)

PMID26679857 (opens in a new tab)DOI10.2174/1567205013666151218150004 (opens in a new tab)PepBankPUB-26679857
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In 10-month-old SAMP8 mice, 8 weeks of SS31 rescued the mitochondrial and synaptic deterioration seen by electron microscopy.

    In plain wordsIn old mice that model Alzheimer's disease, SS31 reversed damage to mitochondria and synapses seen under the electron microscope.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial and synaptic ultrastructure (electron microscopy)
    Study

    mousen: not reported in source

    SAMP8 mice (senescence-accelerated model of Alzheimer's disease)
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    5 mg/kg/day · intraperitoneal · 8 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Electron microscopic analysis revealed mitochondrial/synaptic deterioration in 10 months-old SAMP8 relative to SAMR1 mice, with the changes in the former rescued following 8 weeks treatment with SS31 (5 mg/kg/day, i.p.).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In SAMP8 mice, SS31 treatment restored the elevated hippocampal Aβ42 level.

    In plain wordsIn mice that model Alzheimer's disease, SS31 brought raised brain beta-amyloid back toward normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHippocampal Aβ42 level
    Study

    mousen: not reported in source

    SAMP8 mice (senescence-accelerated model of Alzheimer's disease)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 mg/kg/day · intraperitoneal · 8 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The above altered protein expressions in the SAMP8 mouse brain were restored with the SS31 treatment.
    2 context sentences
    Summary · context
    Elevation of Aβ42, mitochondrial fission protein (DLP1, Fis1) and matrix protein cyclophilin D (CypD), and reductions of mitochondrial fusion protein (Mfn2) and synaptic (i.e., synaptophysin, postsynaptic density protein 95 and growth associated protein 43) proteins, were detected in hippocampal lys…
    Summary · context
    In the present study we characterized mitochondrial and synaptic alterations in SAMP8 mice relative to SAMR1control mice and explored a protective effect of the small molecule peptide SS31, a cell membrane penetrant antioxidant, on mitochondrial and synaptic protein integrity as well as cognitive performance.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In SAMP8 mice, SS31 treatment restored the elevated mitochondrial fission proteins DLP1 and Fis1 and matrix protein CypD in hippocampal lysates.

    In plain wordsIn mice that model Alzheimer's disease, SS31 restored raised mitochondrial fission proteins in the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial fission proteins (DLP1, Fis1) and cyclophilin D in hippocampus
    Study

    mousen: not reported in source

    SAMP8 mice (senescence-accelerated model of Alzheimer's disease)
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    5 mg/kg/day · intraperitoneal · 8 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The above altered protein expressions in the SAMP8 mouse brain were restored with the SS31 treatment.
    2 context sentences
    Summary · context
    Elevation of Aβ42, mitochondrial fission protein (DLP1, Fis1) and matrix protein cyclophilin D (CypD), and reductions of mitochondrial fusion protein (Mfn2) and synaptic (i.e., synaptophysin, postsynaptic density protein 95 and growth associated protein 43) proteins, were detected in hippocampal lys…
    Summary · context
    In the present study we characterized mitochondrial and synaptic alterations in SAMP8 mice relative to SAMR1control mice and explored a protective effect of the small molecule peptide SS31, a cell membrane penetrant antioxidant, on mitochondrial and synaptic protein integrity as well as cognitive performance.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In SAMP8 mice, SS31 treatment restored the reduced mitochondrial fusion protein Mfn2 in hippocampal lysates.

    In plain wordsIn mice that model Alzheimer's disease, SS31 restored a lowered mitochondrial fusion protein in the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial fusion protein Mfn2 in hippocampus
    Study

    mousen: not reported in source

    SAMP8 mice (senescence-accelerated model of Alzheimer's disease)
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    5 mg/kg/day · intraperitoneal · 8 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The above altered protein expressions in the SAMP8 mouse brain were restored with the SS31 treatment.
    2 context sentences
    Summary · context
    Elevation of Aβ42, mitochondrial fission protein (DLP1, Fis1) and matrix protein cyclophilin D (CypD), and reductions of mitochondrial fusion protein (Mfn2) and synaptic (i.e., synaptophysin, postsynaptic density protein 95 and growth associated protein 43) proteins, were detected in hippocampal lys…
    Summary · context
    In the present study we characterized mitochondrial and synaptic alterations in SAMP8 mice relative to SAMR1control mice and explored a protective effect of the small molecule peptide SS31, a cell membrane penetrant antioxidant, on mitochondrial and synaptic protein integrity as well as cognitive performance.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In SAMP8 mice, SS31 treatment restored the reduced synaptic proteins synaptophysin, PSD95 and GAP43 in hippocampal lysates.

    In plain wordsIn mice that model Alzheimer's disease, SS31 restored lowered synapse proteins in the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSynaptic proteins (synaptophysin, PSD95, GAP43) in hippocampus
    Study

    mousen: not reported in source

    SAMP8 mice (senescence-accelerated model of Alzheimer's disease)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 mg/kg/day · intraperitoneal · 8 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The above altered protein expressions in the SAMP8 mouse brain were restored with the SS31 treatment.
    2 context sentences
    Summary · context
    Elevation of Aβ42, mitochondrial fission protein (DLP1, Fis1) and matrix protein cyclophilin D (CypD), and reductions of mitochondrial fusion protein (Mfn2) and synaptic (i.e., synaptophysin, postsynaptic density protein 95 and growth associated protein 43) proteins, were detected in hippocampal lys…
    Summary · context
    In the present study we characterized mitochondrial and synaptic alterations in SAMP8 mice relative to SAMR1control mice and explored a protective effect of the small molecule peptide SS31, a cell membrane penetrant antioxidant, on mitochondrial and synaptic protein integrity as well as cognitive performance.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In 10-month-old SAMP8 mice, SS31 treatment rescued learning and memory deficits.

    In plain wordsIn old mice that model Alzheimer's disease, SS31 reversed learning and memory problems.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseLearning and memory performance
    Study

    mousen: not reported in source

    SAMP8 mice (senescence-accelerated model of Alzheimer's disease)
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    5 mg/kg/day · intraperitoneal · 8 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, the SS31 treatment rescued learning and memory deficits detected in 10 month-old SAMP8 mice.
    1 context sentence
    Summary · context
    In the present study we characterized mitochondrial and synaptic alterations in SAMP8 mice relative to SAMR1control mice and explored a protective effect of the small molecule peptide SS31, a cell membrane penetrant antioxidant, on mitochondrial and synaptic protein integrity as well as cognitive performance.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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