Skip to content

Study · Randomized controlled trial · n = 145 · 2016

6 results

Comparative study of vaginal danazol vs diphereline (a synthetic GnRH agonist) in the control of bleeding during hysteroscopic myomectomy in women with abnormal uterine bleeding: a randomized controlled clinical trial.

Sayyah-Melli M, Bidadi S, Taghavi S, Ouladsahebmadarek E, Jafari-Shobeiri M, Ghojazadeh M, Rahmani V

European journal of obstetrics, gynecology, and reproductive biology26 Nov 2015Cited by 3 (Europe PMC)

PMID26675055 (opens in a new tab)DOI10.1016/j.ejogrb.2015.10.021 (opens in a new tab)PepBankPUB-26675055
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In women undergoing hysteroscopic myomectomy, bleeding was more severe with diphereline than vaginal danazol.

    In plain wordsIn women undergoing myomectomy, bleeding was more severe with diphereline than vaginal danazol.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseIntra-operative bleeding severity
    Study

    n = 145

    Comparator
    Vaginal danazol
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated · intramuscularAs given in this study (human).

    Measurements

    No bleeding
    19.4%
    diphereline
    Mild bleeding
    31.9%
    diphereline
    Moderate bleeding
    45.8%
    diphereline
    Severe bleeding
    2.8%
    diphereline
    No bleeding
    78.1%
    danazol
    Mild bleeding
    21.9%
    danazol

    Source sentences

    Summary
    In the diphereline group, 19.4% of patients experienced no intra-operative uterine bleeding, but mild, moderate and severe bleeding was observed in 31.9%, 45.8% and 2.8% of patients, respectively.
    Summary
    In the danazol group, 78.1% of patients experienced no intra-operative uterine bleeding, and 21.9% experienced mild bleeding.
    3 context sentences
    Summary · context
    The difference between the groups was significant (p<0.001).
    Summary · context
    Randomized controlled clinical trial.
    Summary · context
    One hundred and sixty participants with submucous myomas were allocated at random to receive either vaginal danazol (200mg BID, 30 days before surgery) or intramuscular diphereline (twice with a 28-day interval).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women undergoing hysteroscopy, diphereline produced a clear visual field less often than vaginal danazol.

    In plain wordsIn women undergoing hysteroscopy, diphereline produced a clear visual field less often than vaginal danazol.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseClear visual field
    Study

    n = 145

    Comparator
    Vaginal danazol
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated · intramuscularAs given in this study (human).

    Measurements

    Clear visual field
    29.2%
    diphereline
    Clear visual field
    98.6%
    danazol

    Source sentences

    Summary
    A clear visual field was reported more frequently in the danazol group compared with the diphereline group (98.6% vs 29.2%, p<0.001).
    2 context sentences
    Summary · context
    Randomized controlled clinical trial.
    Summary · context
    One hundred and sixty participants with submucous myomas were allocated at random to receive either vaginal danazol (200mg BID, 30 days before surgery) or intramuscular diphereline (twice with a 28-day interval).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In women undergoing hysteroscopy, operative time did not differ significantly between diphereline and danazol.

    In plain wordsIn women undergoing hysteroscopy, operative time did not differ significantly between diphereline and danazol.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeOperative time
    Study

    n = 145

    Comparator
    Vaginal danazol
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated · intramuscularAs given in this study (human).

    Measurements

    Operative time
    10.6 min
    diphereline
    Operative time
    10.9 min
    danazol

    Source sentences

    Summary
    The mean operative time was 10.9 min and 10.6 min in the danazol and diphereline groups, respectively (p=0.79).
    2 context sentences
    Summary · context
    Randomized controlled clinical trial.
    Summary · context
    One hundred and sixty participants with submucous myomas were allocated at random to receive either vaginal danazol (200mg BID, 30 days before surgery) or intramuscular diphereline (twice with a 28-day interval).
  4. 04HumanRandomized controlled trialEfficacy outcome

    In women undergoing hysteroscopy, infused media volume was similar with diphereline and danazol.

    In plain wordsIn women undergoing hysteroscopy, infused media volume was similar with diphereline and danazol.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeInfused media volume
    Study

    n = 145

    Comparator
    Vaginal danazol
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated · intramuscularAs given in this study (human).

    Measurements

    Infused media
    2 L
    both groups

    Source sentences

    Summary
    The mean volume of infused media was 2.0L in both groups (p=0.99).
    2 context sentences
    Summary · context
    Randomized controlled clinical trial.
    Summary · context
    One hundred and sixty participants with submucous myomas were allocated at random to receive either vaginal danazol (200mg BID, 30 days before surgery) or intramuscular diphereline (twice with a 28-day interval).
  5. 05HumanRandomized controlled trialEfficacy outcome

    In women undergoing hysteroscopy, operation success was equal with diphereline and danazol.

    In plain wordsIn women undergoing hysteroscopy, operation success was equal with diphereline and danazol.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeOperation completion success
    Study

    n = 145

    Comparator
    Vaginal danazol
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated · intramuscularAs given in this study (human).

    Measurements

    Success rate
    100%
    both groups

    Source sentences

    Summary
    The success rate was 100% for both groups with no intra-operative complications.
    2 context sentences
    Summary · context
    Randomized controlled clinical trial.
    Summary · context
    One hundred and sixty participants with submucous myomas were allocated at random to receive either vaginal danazol (200mg BID, 30 days before surgery) or intramuscular diphereline (twice with a 28-day interval).
  6. 06HumanRandomized controlled trialSafety outcome

    In women undergoing hysteroscopy, neither the diphereline nor danazol group had intra-operative complications.

    In plain wordsIn women undergoing hysteroscopy, neither the diphereline nor danazol group had intra-operative complications.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableIntra-operative complications
    Study

    n = 145

    Comparator
    Vaginal danazol
    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    Dose not stated · intramuscularAs given in this study (human).

    Source sentences

    Summary
    The success rate was 100% for both groups with no intra-operative complications.
    2 context sentences
    Summary · context
    Randomized controlled clinical trial.
    Summary · context
    One hundred and sixty participants with submucous myomas were allocated at random to receive either vaginal danazol (200mg BID, 30 days before surgery) or intramuscular diphereline (twice with a 28-day interval).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.