Effects of thymosin β4 on a rat model of severe acute pancreatitis.

He X, Yu J, Guo W, Zuo T, Shi Q, Zhao K, Wang W

Experimental and therapeutic medicine14 Oct 2015Cited by 3 (Europe PMC)

PMID26668646PMCIDPMC4665812DOI10.3892/etm.2015.2798PepBankPUB-26668646

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with sodium taurocholate-induced severe acute pancreatitis, prophylactic thymosin β4 attenuated serum amylase activity.
In plain wordsIn rats with severe pancreatitis, thymosin beta‑4 given beforehand lowered serum amylase.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseSerum amylase activity
Study
ratn: not reported in source
Outcome group
Organ injury · Gastrointestinal
Studied dose
30 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Prophylactic administration of thymosin β4 was found to attenuate serum amylase and lipase activity and the serum concentrations of proinflammatory cytokines.
2 context sentences(design, population, supporting numbers)
Summary · context
SAP was induced by the retrograde infusion of 5% STC (1 ml/kg) into the bile-pancreatic duct.
Summary · context
In certain rats, thymosin β4 (30 mg/kg) was administered intraperitoneally 30 min prior to the infusion of STC.
Report a problemFND-2666864601
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with sodium taurocholate-induced severe acute pancreatitis, prophylactic thymosin β4 attenuated serum lipase activity.
In plain wordsIn rats with severe pancreatitis, thymosin beta‑4 given beforehand lowered serum lipase.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseSerum lipase activity
Study
ratn: not reported in source
Outcome group
Organ injury · Gastrointestinal
Studied dose
30 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Prophylactic administration of thymosin β4 was found to attenuate serum amylase and lipase activity and the serum concentrations of proinflammatory cytokines.
2 context sentences(design, population, supporting numbers)
Summary · context
SAP was induced by the retrograde infusion of 5% STC (1 ml/kg) into the bile-pancreatic duct.
Summary · context
In certain rats, thymosin β4 (30 mg/kg) was administered intraperitoneally 30 min prior to the infusion of STC.
Report a problemFND-2666864602
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with sodium taurocholate-induced severe acute pancreatitis, prophylactic thymosin β4 attenuated the serum concentrations of proinflammatory cytokines.
In plain wordsIn rats with severe pancreatitis, thymosin beta‑4 given beforehand lowered blood levels of inflammatory cytokines.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseSerum proinflammatory cytokines
Study
ratn: not reported in source
Outcome group
Inflammation markers · Gastrointestinal
Studied dose
30 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Prophylactic administration of thymosin β4 was found to attenuate serum amylase and lipase activity and the serum concentrations of proinflammatory cytokines.
3 context sentences(design, population, supporting numbers)
Summary · context
The severity of pancreatitis was evaluated by the measurement of serum amylase, lipase, tumor necrosis factor-α, interleukin (IL)-1β, IL-6 and myeloperoxidase (MPO) levels, and histological grading.
Summary · context
SAP was induced by the retrograde infusion of 5% STC (1 ml/kg) into the bile-pancreatic duct.
Summary · context
In certain rats, thymosin β4 (30 mg/kg) was administered intraperitoneally 30 min prior to the infusion of STC.
Report a problemFND-2666864603
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with severe acute pancreatitis, thymosin β4 attenuated pathological pancreatic injury.
In plain wordsIn rats with severe pancreatitis, thymosin beta‑4 lessened damage to the pancreas.
Peptide
Thymosin beta-4 (human)
Outcome
DecreasePathological pancreatic injury
Study
ratn: not reported in source
Outcome group
Organ injury · Gastrointestinal
Studied dose
30 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
In addition, it attenuated pathological pancreatic injury, pancreatic MPO activity, and the activation of NF-κB and ICAM-1 in the pancreas.
2 context sentences(design, population, supporting numbers)
Summary · context
SAP was induced by the retrograde infusion of 5% STC (1 ml/kg) into the bile-pancreatic duct.
Summary · context
In certain rats, thymosin β4 (30 mg/kg) was administered intraperitoneally 30 min prior to the infusion of STC.
Report a problemFND-2666864604
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with severe acute pancreatitis, thymosin β4 attenuated pancreatic myeloperoxidase activity.
In plain wordsIn rats with severe pancreatitis, thymosin beta‑4 lowered MPO activity in the pancreas.
Peptide
Thymosin beta-4 (human)
Outcome
DecreasePancreatic MPO activity
Study
ratn: not reported in source
Outcome group
Inflammation markers · Gastrointestinal
Studied dose
30 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
In addition, it attenuated pathological pancreatic injury, pancreatic MPO activity, and the activation of NF-κB and ICAM-1 in the pancreas.
2 context sentences(design, population, supporting numbers)
Summary · context
SAP was induced by the retrograde infusion of 5% STC (1 ml/kg) into the bile-pancreatic duct.
Summary · context
In certain rats, thymosin β4 (30 mg/kg) was administered intraperitoneally 30 min prior to the infusion of STC.
Report a problemFND-2666864605
06AnimalAnimal study (in vivo)Mechanism
In rats with severe acute pancreatitis, thymosin β4 attenuated NF-κB activation in the pancreas.
In plain wordsIn rats with severe pancreatitis, thymosin beta‑4 lowered NF-κB activation in the pancreas.
Peptide
Thymosin beta-4 (human)
Outcome
DecreasePancreatic NF-κB activation
Study
ratn: not reported in source
Outcome group
Inflammation markers · Gastrointestinal
Studied dose
30 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
In addition, it attenuated pathological pancreatic injury, pancreatic MPO activity, and the activation of NF-κB and ICAM-1 in the pancreas.
2 context sentences(design, population, supporting numbers)
Summary · context
SAP was induced by the retrograde infusion of 5% STC (1 ml/kg) into the bile-pancreatic duct.
Summary · context
In certain rats, thymosin β4 (30 mg/kg) was administered intraperitoneally 30 min prior to the infusion of STC.
Report a problemFND-2666864606
07AnimalAnimal study (in vivo)Mechanism
In rats with severe acute pancreatitis, thymosin β4 attenuated ICAM-1 activation in the pancreas.
In plain wordsIn rats with severe pancreatitis, thymosin beta‑4 lowered ICAM-1 activation in the pancreas.
Peptide
Thymosin beta-4 (human)
Outcome
DecreasePancreatic ICAM-1 activation
Study
ratn: not reported in source
Outcome group
Inflammation markers · Gastrointestinal
Studied dose
30 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
In addition, it attenuated pathological pancreatic injury, pancreatic MPO activity, and the activation of NF-κB and ICAM-1 in the pancreas.
2 context sentences(design, population, supporting numbers)
Summary · context
SAP was induced by the retrograde infusion of 5% STC (1 ml/kg) into the bile-pancreatic duct.
Summary · context
In certain rats, thymosin β4 (30 mg/kg) was administered intraperitoneally 30 min prior to the infusion of STC.
Report a problemFND-2666864607

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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