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Study · Not a test of the peptide alone · 2015

4 results

Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults.

Rokicki J, Li L, Imabayashi E, Kaneko J, Hisatsune T, Matsuda H

Frontiers in aging neuroscience27 Nov 2015Cited by 53 (Europe PMC)

PMID26640437 (opens in a new tab)PMCIDPMC4661275 (opens in a new tab)DOI10.3389/fnagi.2015.00219 (opens in a new tab)PepBankPUB-26640437
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Summary

Carnosine and anserine are strong antioxidants, previously demonstrated to reduce cognitive decline in animal studies. We aimed to investigate their cognitive and neurophysiological effects, using functional MRI, on humans. Thirty-one healthy participants (age 40-78, 10 male/21 female) were recruited to a double-blind placebo-controlled study. Participants were assigned to twice-daily doses of imidazole dipeptide formula (n = 14), containing 500 mg (carnosine/anserine, ratio 1/3) or an identical placebo (n = 17). Functional MRI and neuropsychological assessments were carried out at baseline and after 3 months of supplementation. We analyzed resting state functional connectivity with the FSL fMRI analysis package. There were no differences in neuropsychological scores between the groups at baseline. After 3 months of supplementation, the carnosine/anserine group had better verbal episodic memory performance and decreased connectivity in the default mode network, the posterior cingulate cortex and the right fronto parietal network, as compared with the placebo group. Furthermore, there was a correlation between the extents of cognitive and neuroimaging changes. These results suggest that daily carnosine/anserine supplementation can impact cognitive function and that network connectivity changes are associated with its effects.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

  1. 01HumanNot a test of L-carnosine aloneNon-randomized trialEfficacy outcome

    In healthy adults, the carnosine/anserine formula improved verbal episodic memory performance compared with placebo after 3 months.

    In plain wordsIn healthy adults, the carnosine/anserine formula improved verbal episodic memory compared with placebo after 3 months.

    Peptide
    L-carnosine
    Outcome
    IncreaseVerbal episodic memory
    Study

    n = 31

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    After 3 months of supplementation, the carnosine/anserine group had better verbal episodic memory performance and decreased connectivity in the default mode network, the posterior cingulate cortex and the right fronto parietal network, as compared with the placebo group.
    3 context sentences
    Summary · context
    Thirty-one healthy participants (age 40-78, 10 male/21 female) were recruited to a double-blind placebo-controlled study.
    Summary · context
    Participants were assigned to twice-daily doses of imidazole dipeptide formula (n = 14), containing 500 mg (carnosine/anserine, ratio 1/3) or an identical placebo (n = 17).
    Summary · context
    Functional MRI and neuropsychological assessments were carried out at baseline and after 3 months of supplementation.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  2. 02HumanNot a test of L-carnosine aloneNon-randomized trialEfficacy outcome

    In healthy adults, the carnosine/anserine formula decreased default mode network connectivity compared with placebo after 3 months.

    In plain wordsIn healthy adults, the carnosine/anserine formula decreased default mode network connectivity compared with placebo after 3 months.

    Peptide
    L-carnosine
    Outcome
    DecreaseDefault mode network connectivity
    Study

    n = 31

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    After 3 months of supplementation, the carnosine/anserine group had better verbal episodic memory performance and decreased connectivity in the default mode network, the posterior cingulate cortex and the right fronto parietal network, as compared with the placebo group.
    3 context sentences
    Summary · context
    Thirty-one healthy participants (age 40-78, 10 male/21 female) were recruited to a double-blind placebo-controlled study.
    Summary · context
    Participants were assigned to twice-daily doses of imidazole dipeptide formula (n = 14), containing 500 mg (carnosine/anserine, ratio 1/3) or an identical placebo (n = 17).
    Summary · context
    Functional MRI and neuropsychological assessments were carried out at baseline and after 3 months of supplementation.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  3. 03HumanNot a test of L-carnosine aloneNon-randomized trialEfficacy outcome

    In healthy adults, the carnosine/anserine formula decreased posterior cingulate cortex connectivity compared with placebo after 3 months.

    In plain wordsIn healthy adults, the carnosine/anserine formula decreased posterior cingulate cortex connectivity compared with placebo after 3 months.

    Peptide
    L-carnosine
    Outcome
    DecreasePosterior cingulate cortex connectivity
    Study

    n = 31

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    After 3 months of supplementation, the carnosine/anserine group had better verbal episodic memory performance and decreased connectivity in the default mode network, the posterior cingulate cortex and the right fronto parietal network, as compared with the placebo group.
    3 context sentences
    Summary · context
    Thirty-one healthy participants (age 40-78, 10 male/21 female) were recruited to a double-blind placebo-controlled study.
    Summary · context
    Participants were assigned to twice-daily doses of imidazole dipeptide formula (n = 14), containing 500 mg (carnosine/anserine, ratio 1/3) or an identical placebo (n = 17).
    Summary · context
    Functional MRI and neuropsychological assessments were carried out at baseline and after 3 months of supplementation.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  4. 04HumanNot a test of L-carnosine aloneNon-randomized trialEfficacy outcome

    In healthy adults, the carnosine/anserine formula decreased right fronto parietal network connectivity compared with placebo after 3 months.

    In plain wordsIn healthy adults, the carnosine/anserine formula decreased right fronto parietal network connectivity compared with placebo after 3 months.

    Peptide
    L-carnosine
    Outcome
    DecreaseRight fronto parietal network connectivity
    Study

    n = 31

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    After 3 months of supplementation, the carnosine/anserine group had better verbal episodic memory performance and decreased connectivity in the default mode network, the posterior cingulate cortex and the right fronto parietal network, as compared with the placebo group.
    3 context sentences
    Summary · context
    Thirty-one healthy participants (age 40-78, 10 male/21 female) were recruited to a double-blind placebo-controlled study.
    Summary · context
    Participants were assigned to twice-daily doses of imidazole dipeptide formula (n = 14), containing 500 mg (carnosine/anserine, ratio 1/3) or an identical placebo (n = 17).
    Summary · context
    Functional MRI and neuropsychological assessments were carried out at baseline and after 3 months of supplementation.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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