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Study · Animal study (in vivo) · rat · 2014

7 results

Mechanistic Study on Triptorelin Action in Protecting From 5-FU-Induced Ovarian Damage in Rats.

Wang Y, Tian X, Liang L, Wang Y, Wang R, Cheng X, Yan Z, Chen Y, Qi P

Oncology research1 Jan 2014Cited by 12 (Europe PMC)

PMID26629940 (opens in a new tab)PMCIDPMC7842582 (opens in a new tab)DOI10.3727/096504015x14410238486720 (opens in a new tab)PepBankPUB-26629940
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with 5-FU-induced ovarian damage, triptorelin increased the ovarian wet weight to body weight ratio versus 5-FU alone.

    In plain wordsIn rats with ovarian damage, triptorelin increased the ovarian weight ratio versus 5-FU alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseOvarian wet weight to body weight ratio
    Study

    ratn: not reported in source

    Sprague-Dawley rats with 5-FU-induced ovarian damage
    Comparator
    5-FU alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, after coadministration of triptorelin with 5-FU, the ratio of ovarian wet weight to body weight and the levels of AMH were significantly increased, whereas the level of E2 and FSH was decreased significantly when compared with the 5-FU group.
    1 context sentence
    Summary · context
    This study aimed to discover the underlying mechanism of triptorelin in protection from 5-fluorouracil (5-FU)-induced ovarian damage in Sprague-Dawley rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with 5-FU-induced ovarian damage, triptorelin increased AMH versus 5-FU alone.

    In plain wordsIn rats with ovarian damage, triptorelin increased AMH versus 5-FU alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseAMH
    Study

    ratn: not reported in source

    Sprague-Dawley rats with 5-FU-induced ovarian damage
    Comparator
    5-FU alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, after coadministration of triptorelin with 5-FU, the ratio of ovarian wet weight to body weight and the levels of AMH were significantly increased, whereas the level of E2 and FSH was decreased significantly when compared with the 5-FU group.
    1 context sentence
    Summary · context
    This study aimed to discover the underlying mechanism of triptorelin in protection from 5-fluorouracil (5-FU)-induced ovarian damage in Sprague-Dawley rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with 5-FU-induced ovarian damage, triptorelin decreased E2 versus 5-FU alone.

    In plain wordsIn rats with ovarian damage, triptorelin decreased E2 versus 5-FU alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseEstradiol
    Study

    ratn: not reported in source

    Sprague-Dawley rats with 5-FU-induced ovarian damage
    Comparator
    5-FU alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, after coadministration of triptorelin with 5-FU, the ratio of ovarian wet weight to body weight and the levels of AMH were significantly increased, whereas the level of E2 and FSH was decreased significantly when compared with the 5-FU group.
    1 context sentence
    Summary · context
    This study aimed to discover the underlying mechanism of triptorelin in protection from 5-fluorouracil (5-FU)-induced ovarian damage in Sprague-Dawley rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with 5-FU-induced ovarian damage, triptorelin decreased FSH versus 5-FU alone.

    In plain wordsIn rats with ovarian damage, triptorelin decreased FSH versus 5-FU alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseFSH
    Study

    ratn: not reported in source

    Sprague-Dawley rats with 5-FU-induced ovarian damage
    Comparator
    5-FU alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, after coadministration of triptorelin with 5-FU, the ratio of ovarian wet weight to body weight and the levels of AMH were significantly increased, whereas the level of E2 and FSH was decreased significantly when compared with the 5-FU group.
    1 context sentence
    Summary · context
    This study aimed to discover the underlying mechanism of triptorelin in protection from 5-fluorouracil (5-FU)-induced ovarian damage in Sprague-Dawley rats.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with 5-FU-induced ovarian damage, triptorelin increased Bcl-2 expression versus 5-FU alone.

    In plain wordsIn rats with ovarian damage, triptorelin increased Bcl-2 expression versus 5-FU alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseBcl-2 expression
    Study

    ratn: not reported in source

    Sprague-Dawley rats with 5-FU-induced ovarian damage
    Comparator
    5-FU alone
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, at indicated times, 5-FU led to the reduced Bcl-2 and NF-κB expression and increased Bax expression while triptorelin plus 5-FU increased Bcl-2 and NF-κB expression and decreased Bax expression.
    1 context sentence
    Summary · context
    This study aimed to discover the underlying mechanism of triptorelin in protection from 5-fluorouracil (5-FU)-induced ovarian damage in Sprague-Dawley rats.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with 5-FU-induced ovarian damage, triptorelin increased NF-κB expression versus 5-FU alone.

    In plain wordsIn rats with ovarian damage, triptorelin increased NF-κB expression versus 5-FU alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseNF-κB expression
    Study

    ratn: not reported in source

    Sprague-Dawley rats with 5-FU-induced ovarian damage
    Comparator
    5-FU alone
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, at indicated times, 5-FU led to the reduced Bcl-2 and NF-κB expression and increased Bax expression while triptorelin plus 5-FU increased Bcl-2 and NF-κB expression and decreased Bax expression.
    1 context sentence
    Summary · context
    This study aimed to discover the underlying mechanism of triptorelin in protection from 5-fluorouracil (5-FU)-induced ovarian damage in Sprague-Dawley rats.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats with 5-FU-induced ovarian damage, triptorelin decreased Bax expression versus 5-FU alone.

    In plain wordsIn rats with ovarian damage, triptorelin decreased Bax expression versus 5-FU alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseBax expression
    Study

    ratn: not reported in source

    Sprague-Dawley rats with 5-FU-induced ovarian damage
    Comparator
    5-FU alone
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, at indicated times, 5-FU led to the reduced Bcl-2 and NF-κB expression and increased Bax expression while triptorelin plus 5-FU increased Bcl-2 and NF-κB expression and decreased Bax expression.
    1 context sentence
    Summary · context
    This study aimed to discover the underlying mechanism of triptorelin in protection from 5-fluorouracil (5-FU)-induced ovarian damage in Sprague-Dawley rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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