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Study · In vitro (cells) · rat · 2016

4 results

Thymosin β4 Prevents Angiotensin II-Induced Cardiomyocyte Growth by Regulating Wnt/WISP Signaling.

Li L, Guleria RS, Thakur S, Zhang CL, Pan J, Baker KM, Gupta S

Journal of cellular physiology16 Mar 2016Cited by 13 (Europe PMC)

PMID26627308 (opens in a new tab)DOI10.1002/jcp.25275 (opens in a new tab)PepBankPUB-26627308
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In neonatal rat ventricular cardiomyocytes, Tβ4 pre-treatment reduced the cell size increase induced by angiotensin II.

    In plain wordsIn rat heart cells in the lab, Tβ4 pre-treatment reduced the cell enlargement caused by angiotensin II.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCardiomyocyte cell size
    Study

    ratn: not reported in source

    Neonatal rat ventricular cardiomyocytes (NRVM)
    Comparator
    Ang II stimulation without Tβ4
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pre-treatment of Tβ4 resulted in reduction of cell size, hypertrophy marker genes and Wnt-associated gene expression, and protein levels; induced by Ang II in cardiomyocyte.
    1 context sentence
    Summary · context
    Neonatal rat ventricular cardiomyocytes (NRVM) were pretreated with Tβ4 followed by Ang II stimulation.
  2. 02LabIn vitro (cells)Mechanism

    In neonatal rat ventricular cardiomyocytes, Tβ4 pre-treatment reduced the hypertrophy marker genes induced by angiotensin II.

    In plain wordsIn rat heart cells in the lab, Tβ4 pre-treatment lowered the growth-marker genes raised by angiotensin II.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseHypertrophy marker gene expression
    Study

    ratn: not reported in source

    Neonatal rat ventricular cardiomyocytes (NRVM)
    Comparator
    Ang II stimulation without Tβ4
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pre-treatment of Tβ4 resulted in reduction of cell size, hypertrophy marker genes and Wnt-associated gene expression, and protein levels; induced by Ang II in cardiomyocyte.
    1 context sentence
    Summary · context
    Neonatal rat ventricular cardiomyocytes (NRVM) were pretreated with Tβ4 followed by Ang II stimulation.
  3. 03LabIn vitro (cells)Mechanism

    In neonatal rat ventricular cardiomyocytes, Tβ4 pre-treatment reduced the Wnt-associated gene expression and protein levels induced by angiotensin II.

    In plain wordsIn rat heart cells in the lab, Tβ4 pre-treatment lowered Wnt signaling genes and proteins raised by angiotensin II.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseWnt-associated gene expression and protein levels
    Study

    ratn: not reported in source

    Neonatal rat ventricular cardiomyocytes (NRVM)
    Comparator
    Ang II stimulation without Tβ4
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pre-treatment of Tβ4 resulted in reduction of cell size, hypertrophy marker genes and Wnt-associated gene expression, and protein levels; induced by Ang II in cardiomyocyte.
    1 context sentence
    Summary · context
    Neonatal rat ventricular cardiomyocytes (NRVM) were pretreated with Tβ4 followed by Ang II stimulation.
  4. 04LabIn vitro (cells)Efficacy outcome

    In neonatal rat ventricular cardiomyocytes, pre-treatment with Tβ4 reversed the cell growth promoted by WISP-1 overexpression.

    In plain wordsIn rat heart cells in the lab, Tβ4 pre-treatment reversed the extra cell growth caused by too much WISP-1.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseWISP-1 overexpression-induced cardiomyocyte growth
    Study

    ratn: not reported in source

    Neonatal rat ventricular cardiomyocytes (NRVM)
    Comparator
    WISP-1 overexpression without Tβ4
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    WISP-1 overexpression promoted cardiomyocytes growth and was reversed by pretreatment with Tβ4.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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