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Study · Animal study (in vivo) · rat · 2015

4 results

BPC 157 antagonized the general anaesthetic potency of thiopental and reduced prolongation of anaesthesia induced by L-NAME/thiopental combination.

Zemba M, Cilic AZ, Balenovic I, Cilic M, Radic B, Suran J, Drmic D, Kokot A, Stambolija V, Murselovic T, Holjevac JK, Uzun S and 4 more

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Djuzel V, Vlainic J, Seiwerth S, Sikiric P

Inflammopharmacology13 Nov 2015Cited by 11 (Europe PMC)

PMID26563892 (opens in a new tab)DOI10.1007/s10787-015-0249-9 (opens in a new tab)PepBankPUB-26563892
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, BPC‑157 antagonised general anaesthesia produced by thiopental, with a parallel shift of the dose-response curve to the right.

    In plain wordsIn rats, BPC‑157 weakened the anaesthetic effect of thiopental.

    Peptide
    BPC-157
    Outcome
    DecreaseGeneral anaesthetic potency of thiopental
    Study

    ratn: not reported in source

    thiopental anaesthesia
    Comparator
    Thiopental alone
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    10 ng/kg, 10 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    (1) BPC 157 own effect on thiopental anaesthesia: BPC 157 (10 ng/kg and 10 μg/kg) caused a significant antagonism of general anaesthesia produced by thiopental with a parallel shift of the dose-response curve to the right.
    1 context sentence
    Summary · context
    (1) All rats intraperitoneally received thiopental (20, 30, 40, and 50 mg/kg) while medication BPC 157 (10 μg/kg, 10 ng/kg, and 10 pg/kg) was given intraperitoneally at 5 min before thiopental.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, BPC‑157 abolished the potentiating effects of L-NAME on thiopental anaesthesia.

    In plain wordsIn rats, BPC‑157 removed the extra anaesthesia time caused by L-NAME.

    Peptide
    BPC-157
    Outcome
    DecreaseL-NAME prolongation of thiopental anaesthesia
    Study

    ratn: not reported in source

    thiopental anaesthesia
    Comparator
    L-NAME and thiopental
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    10 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 and L-NAME: Potentiating effects of L-NAME were abolished.
    1 context sentence
    Summary · context
    (2) To determine NO-related mechanisms, all rats received intraperitoneally thiopental 40 mg/kg while BPC 157 (10 μg/kg), L-NAME (10 mg/kg) and L-arginine (30 mg/kg) were applied alone and/or combined.

Studies that did not test the peptide alone2

In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking BPC-157.

  1. 03AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Efficacy outcome

    In rats, the shortening effect of BPC‑157 on thiopental anaesthesia was abolished when L-arginine was given.

    In plain wordsIn rats, giving L-arginine removed the shortening effect of BPC‑157 on anaesthesia time.

    Peptide
    BPC-157
    Outcome
    No significant changeBPC 157 shortening effect when given with L-arginine
    Study

    ratn: not reported in source

    thiopental anaesthesia
    Comparator
    BPC 157 alone
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    shortening effect of BPC 157: abolished.
    1 context sentence
    Summary · context
    (2) To determine NO-related mechanisms, all rats received intraperitoneally thiopental 40 mg/kg while BPC 157 (10 μg/kg), L-NAME (10 mg/kg) and L-arginine (30 mg/kg) were applied alone and/or combined.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

  2. 04AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Efficacy outcome

    In rats, anaesthesia values with BPC‑157 plus L-NAME plus L-arginine were close to those with BPC‑157 alone.

    In plain wordsIn rats, giving all three agents together gave results close to BPC‑157 alone.

    Peptide
    BPC-157
    Outcome
    No significant changeAnaesthesia with BPC 157, L-NAME and L-arginine together
    Study

    ratn: not reported in source

    thiopental anaesthesia
    Comparator
    BPC 157 alone
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    BPC 157 and L-NAME and L-arginine: BPC 157 +L-NAME +L-arginine rats exhibited values close to those in BPC 157 rats.
    1 context sentence
    Summary · context
    (2) To determine NO-related mechanisms, all rats received intraperitoneally thiopental 40 mg/kg while BPC 157 (10 μg/kg), L-NAME (10 mg/kg) and L-arginine (30 mg/kg) were applied alone and/or combined.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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