Skip to content

Study · Animal study (in vivo) · rat · 2016

7 results

Acute Carnosine Administration Increases Respiratory Chain Complexes and Citric Acid Cycle Enzyme Activities in Cerebral Cortex of Young Rats.

Macedo LW, Cararo JH, Maravai SG, Gonçalves CL, Oliveira GM, Kist LW, Guerra Martinez C, Kurtenbach E, Bogo MR, Hipkiss AR, Streck EL, Schuck PF, Ferreira GC

Molecular neurobiology17 Oct 2015Cited by 19 (Europe PMC)

PMID26476839 (opens in a new tab)DOI10.1007/s12035-015-9475-9 (opens in a new tab)PepBankPUB-26476839
Publisher pagePubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine increased cortical mitochondrial complex I-III activity versus vehicle.

    In plain wordsIn young rats, carnosine increased brain complex I-III activity compared with vehicle.

    Peptide
    L-carnosine
    Outcome
    IncreaseComplex I-III activity
    Study

    ratn: not reported in source

    Young Wistar rat cerebral cortex
    Comparator
    Vehicle-treated animals
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The activity of mitochondrial enzymes in cerebral cortex was assessed using a spectrophotometer, and it was found that there was an increase in the activities of complexes I-III and II-III and succinate dehydrogenase in carnosine-treated rats, as compared to vehicle-treated animals.
    1 context sentence
    Summary · context
    The aim of the present study was to investigate the in vivo effects of acute carnosine administration on various aspects of brain bioenergetics of young Wistar rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine increased cortical mitochondrial complex II-III activity versus vehicle.

    In plain wordsIn young rats, carnosine increased brain complex II-III activity compared with vehicle.

    Peptide
    L-carnosine
    Outcome
    IncreaseComplex II-III activity
    Study

    ratn: not reported in source

    Young Wistar rat cerebral cortex
    Comparator
    Vehicle-treated animals
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The activity of mitochondrial enzymes in cerebral cortex was assessed using a spectrophotometer, and it was found that there was an increase in the activities of complexes I-III and II-III and succinate dehydrogenase in carnosine-treated rats, as compared to vehicle-treated animals.
    1 context sentence
    Summary · context
    The aim of the present study was to investigate the in vivo effects of acute carnosine administration on various aspects of brain bioenergetics of young Wistar rats.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine increased cortical succinate dehydrogenase activity versus vehicle.

    In plain wordsIn young rats, carnosine increased brain succinate dehydrogenase activity compared with vehicle.

    Peptide
    L-carnosine
    Outcome
    IncreaseSuccinate dehydrogenase activity
    Study

    ratn: not reported in source

    Young Wistar rat cerebral cortex
    Comparator
    Vehicle-treated animals
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The activity of mitochondrial enzymes in cerebral cortex was assessed using a spectrophotometer, and it was found that there was an increase in the activities of complexes I-III and II-III and succinate dehydrogenase in carnosine-treated rats, as compared to vehicle-treated animals.
    1 context sentence
    Summary · context
    The aim of the present study was to investigate the in vivo effects of acute carnosine administration on various aspects of brain bioenergetics of young Wistar rats.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine did not significantly alter cortical Nrf1 mRNA levels.

    In plain wordsIn young rats, carnosine did not significantly change brain Nrf1 gene expression compared with vehicle.

    Peptide
    L-carnosine
    Outcome
    No significant changeNrf1 mRNA
    Study

    ratn: not reported in source

    Young Wistar rat cerebral cortex
    Comparator
    Vehicle-treated animals
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, quantitative real-time RT-PCR (RT-qPCR) data on mRNA levels of mitochondrial biogenesis-related proteins (nuclear respiratory factor 1 (Nrf1), peroxisome proliferator-activated receptor-γ coactivator 1-α (Ppargc1α), and mitochondrial transcription factor A (Tfam)) were not altered significantly
    1 context sentence
    Summary · context
    The aim of the present study was to investigate the in vivo effects of acute carnosine administration on various aspects of brain bioenergetics of young Wistar rats.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine did not significantly alter cortical Ppargc1α mRNA levels.

    In plain wordsIn young rats, carnosine did not significantly change brain Ppargc1α gene expression compared with vehicle.

    Peptide
    L-carnosine
    Outcome
    No significant changePpargc1α mRNA
    Study

    ratn: not reported in source

    Young Wistar rat cerebral cortex
    Comparator
    Vehicle-treated animals
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, quantitative real-time RT-PCR (RT-qPCR) data on mRNA levels of mitochondrial biogenesis-related proteins (nuclear respiratory factor 1 (Nrf1), peroxisome proliferator-activated receptor-γ coactivator 1-α (Ppargc1α), and mitochondrial transcription factor A (Tfam)) were not altered significantly
    1 context sentence
    Summary · context
    The aim of the present study was to investigate the in vivo effects of acute carnosine administration on various aspects of brain bioenergetics of young Wistar rats.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine did not significantly alter cortical Tfam mRNA levels.

    In plain wordsIn young rats, carnosine did not significantly change brain Tfam gene expression compared with vehicle.

    Peptide
    L-carnosine
    Outcome
    No significant changeTfam mRNA
    Study

    ratn: not reported in source

    Young Wistar rat cerebral cortex
    Comparator
    Vehicle-treated animals
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, quantitative real-time RT-PCR (RT-qPCR) data on mRNA levels of mitochondrial biogenesis-related proteins (nuclear respiratory factor 1 (Nrf1), peroxisome proliferator-activated receptor-γ coactivator 1-α (Ppargc1α), and mitochondrial transcription factor A (Tfam)) were not altered significantly
    1 context sentence
    Summary · context
    The aim of the present study was to investigate the in vivo effects of acute carnosine administration on various aspects of brain bioenergetics of young Wistar rats.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In young rats, carnosine did not alter respiratory chain complex immunocontent.

    In plain wordsIn young rats, carnosine did not change measured respiratory chain complex amounts compared with vehicle.

    Peptide
    L-carnosine
    Outcome
    No significant changeRespiratory chain complex immunocontent
    Study

    ratn: not reported in source

    Young Wistar rat cerebral cortex
    Comparator
    Vehicle-treated animals
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was in agreement with the finding that immunocontent of respiratory chain complexes was not altered in animals receiving carnosine.
    1 context sentence
    Summary · context
    The aim of the present study was to investigate the in vivo effects of acute carnosine administration on various aspects of brain bioenergetics of young Wistar rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.