Thymosin β4 inhibits microglia activation through microRNA 146a in neonatal rats following hypoxia injury.

Zhou T, Huang YX, Song JW, Ma QM

Neuroreport1 Dec 2015Cited by 18 (Europe PMC)

PMID26457369DOI10.1097/wnr.0000000000000463PepBankPUB-26457369

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
Tβ4 treatment significantly inhibited secretion of inflammatory mediators in the cerebellum of neonatal rats after hypoxia injury.
In plain wordsIn newborn rats, thymosin beta‑4 reduced inflammatory substances in the cerebellum after low-oxygen injury.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseInflammatory mediator secretion in cerebellum after hypoxia
Study
ratn: not reported in source
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
We showed that Tβ4 treatment significantly inhibited secretion of inflammatory mediators in the cerebellum of neonatal rats following hypoxia injury.
1 context sentence(design, population, supporting numbers)
Summary · context
Tβ4 treatment was carried out on 1-day-old rats and BV-2 cells.
Report a problemFND-2645736901
02LabIn vitro (cells)Efficacy outcome
Tβ4 treatment significantly inhibited the expression and secretion of hypoxia-induced TNF-α.
In plain wordsIn cells and rats, thymosin beta‑4 reduced low-oxygen-induced TNF-α production and release.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseHypoxia-induced TNF-α expression and secretion
Study
n: not reported in source
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Tβ4 treatment significantly inhibited the expression and secretion of hypoxia-induced TNF-α, IL-1β, and NO.
1 context sentence(design, population, supporting numbers)
Summary · context
Tβ4 treatment was carried out on 1-day-old rats and BV-2 cells.
Report a problemFND-2645736904
03LabIn vitro (cells)Efficacy outcome
Tβ4 treatment significantly inhibited the expression and secretion of hypoxia-induced IL-1β.
In plain wordsIn cells and rats, thymosin beta‑4 reduced low-oxygen-induced IL-1β production and release.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseHypoxia-induced IL-1β expression and secretion
Study
n: not reported in source
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Tβ4 treatment significantly inhibited the expression and secretion of hypoxia-induced TNF-α, IL-1β, and NO.
1 context sentence(design, population, supporting numbers)
Summary · context
Tβ4 treatment was carried out on 1-day-old rats and BV-2 cells.
Report a problemFND-2645736905
04LabIn vitro (cells)Efficacy outcome
Tβ4 treatment significantly inhibited the expression and secretion of hypoxia-induced NO.
In plain wordsIn cells and rats, thymosin beta‑4 reduced low-oxygen-induced nitric oxide production and release.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseHypoxia-induced nitric oxide expression and secretion
Study
n: not reported in source
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Tβ4 treatment significantly inhibited the expression and secretion of hypoxia-induced TNF-α, IL-1β, and NO.
1 context sentence(design, population, supporting numbers)
Summary · context
Tβ4 treatment was carried out on 1-day-old rats and BV-2 cells.
Report a problemFND-2645736906
05LabIn vitro (cells)Mechanism
MicroRNA 146a expression increased in Tβ4-treated BV-2 cells.
In plain wordsIn cells, thymosin beta‑4 treatment raised microRNA 146a in microglia.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseMicroRNA 146a expression in BV-2 cells
Study
n: not reported in source
BV-2 microglia cells
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Remarkably, microRNA 146a expression was found to have increased in Tβ4-treated BV-2 cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Tβ4 treatment was carried out on 1-day-old rats and BV-2 cells.
Report a problemFND-2645736907

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

06AnimalEndogenous levelAnimal study (in vivo)Mechanism
Expression of endogenous Tβ4 in microglia was increased in hypoxic neonatal rats.
In plain wordsIn rats, the body's own thymosin beta‑4 rose in microglia after low-oxygen injury.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseEndogenous Tβ4 expression in microglia, hypoxic rats
Study
ratn: not reported in source
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Increased expression of endogenous Tβ4 in microglia was observed both in hypoxic rats and in BV-2 cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Tβ4 treatment was carried out on 1-day-old rats and BV-2 cells.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2645736902
07LabEndogenous levelIn vitro (cells)Mechanism
Expression of endogenous Tβ4 was increased in hypoxic BV-2 microglia cells.
In plain wordsIn cells, the body's own thymosin beta‑4 rose in microglia exposed to low oxygen.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseEndogenous Tβ4 expression in BV-2 microglia
Study
n: not reported in source
BV-2 microglia cells
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Increased expression of endogenous Tβ4 in microglia was observed both in hypoxic rats and in BV-2 cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Tβ4 treatment was carried out on 1-day-old rats and BV-2 cells.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2645736903

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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