In laboratory comparisons including pramlintide, inhibitor performance reflected a balance between reduced amyloidogenicity and recognition of human IAPP.
In plain wordsIn lab tests including pramlintide, inhibitor performance reflected a balance between reduced amyloid formation and recognition of human IAPP.
- Peptide
- Pramlintide (Symlin)
- Outcome
- Not applicableAmyloid inhibition and molecular recognition balance
- Study
n: not reported in source
- Outcome group
- Receptor activity and mechanism · Pharmacology
Source sentences
Our results reveal, for this class of molecules, a balance between the reduced amyloidogenicity of the inhibitory sequence on one hand and its ability to recognize hIAPP on the other.
1 context sentence(design, population, supporting numbers)
Here we examine and compare the ability of rIAPP, PM, and a set of designed analogues of hIAPP to inhibit amyloid formation by hIAPP, to elucidate the factors that lead to effective peptide-based inhibitors.
In this study, Pramlintide (Symlin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pramlintide (Symlin).