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Study · Not a test of the peptide alone · 2015

9 results

The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.

Lue Y, Swerdloff R, Wan J, Xiao J, French S, Atienza V, Canela V, Bruhn KW, Stone B, Jia Y, Cohen P, Wang C

Endocrinology18 Sept 2015Cited by 36 (Europe PMC)

PMID26384090 (opens in a new tab)PMCIDPMC4655208 (opens in a new tab)DOI10.1210/en.2015-1542 (opens in a new tab)PepBankPUB-26384090
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone9

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In melanoma-bearing male mice, HNG, a humanin analogue, rescued the cyclophosphamide-induced suppression of leucocytes.

    In plain wordsIn male mice with melanoma, the humanin analogue HNG restored white blood cell counts lowered by cyclophosphamide.

    Peptide
    Humanin
    Outcome
    IncreaseCP-induced suppression of leucocytes in cancer-bearing mice
    Study

    mousen: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    HNG rescued the CP-induced suppression of leucocytes
    1 context sentence
    Summary · context
    We investigated whether a potent humanin analogue S14G-humanin (HNG) would protect against chemotherapy-induced damage to normal cells without interfering with the chemotherapy-induced suppression of cancer cells.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In melanoma-bearing male mice, HNG protected germ cells from cyclophosphamide-induced apoptosis.

    In plain wordsIn male mice with melanoma, the humanin analogue HNG protected sperm-forming cells from cyclophosphamide-induced cell death.

    Peptide
    Humanin
    Outcome
    DecreaseCP-induced germ cell apoptosis in cancer-bearing mice
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    protected germ cell from CP-induced apoptosis.
    1 context sentence
    Summary · context
    We investigated whether a potent humanin analogue S14G-humanin (HNG) would protect against chemotherapy-induced damage to normal cells without interfering with the chemotherapy-induced suppression of cancer cells.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In mice inoculated with murine melanoma cells, HNG alone suppressed lung metastases.

    In plain wordsIn mice with melanoma, the humanin analogue HNG alone reduced the spread of cancer to the lungs.

    Peptide
    Humanin
    Outcome
    DecreaseLung metastases with HNG alone
    Study

    mousen: not reported in source

    Comparator
    No treatment
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Lung metastases were suppressed by HNG or CP alone, and further suppressed by CP+HNG treatment.
    1 context sentence
    Summary · context
    We investigated whether a potent humanin analogue S14G-humanin (HNG) would protect against chemotherapy-induced damage to normal cells without interfering with the chemotherapy-induced suppression of cancer cells.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In mice inoculated with murine melanoma cells, cyclophosphamide plus HNG suppressed lung metastases further than cyclophosphamide alone.

    In plain wordsIn mice with melanoma, adding the humanin analogue HNG to cyclophosphamide reduced the spread of cancer to the lungs more than cyclophosphamide alone.

    Peptide
    Humanin
    Outcome
    DecreaseLung metastases with CP plus HNG versus CP alone
    Study

    mousen: not reported in source

    Comparator
    Cyclophosphamide alone
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Lung metastases were suppressed by HNG or CP alone, and further suppressed by CP+HNG treatment.
    1 context sentence
    Summary · context
    We investigated whether a potent humanin analogue S14G-humanin (HNG) would protect against chemotherapy-induced damage to normal cells without interfering with the chemotherapy-induced suppression of cancer cells.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  5. 05AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In mice, HNG suppressed plasma IGF-1 levels, with or without cyclophosphamide.

    In plain wordsIn mice, the humanin analogue HNG lowered blood IGF-1 levels, with or without cyclophosphamide.

    Peptide
    Humanin
    Outcome
    DecreasePlasma IGF-1 levels
    Study

    mousen: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Plasma IGF-1 levels were suppressed by HNG with or without CP treatment.
    1 context sentence
    Summary · context
    We investigated whether a potent humanin analogue S14G-humanin (HNG) would protect against chemotherapy-induced damage to normal cells without interfering with the chemotherapy-induced suppression of cancer cells.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  6. 06AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In normal adult male mice, cauda epididymal sperm counts were elevated by HNG.

    In plain wordsIn male mice, the humanin analogue HNG raised sperm counts.

    Peptide
    Humanin
    Outcome
    IncreaseCauda epididymal sperm count with HNG
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Cauda epididymal sperm counts were elevated by HNG
    1 context sentence
    Summary · context
    To investigate whether HNG maintains its protective effects on spermatogonial stem cells, sperm output, and peripheral leucocytes after repeated doses of CP, normal adult male mice received: no treatment, daily sc injection of HNG, 6 ip injections of CP at 5-day intervals, and the same regimens of C…

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  7. 07AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In normal adult male mice given repeated cyclophosphamide doses, HNG rescued the suppression of spermatogonial stem cells.

    In plain wordsIn male mice given repeated cyclophosphamide doses, the humanin analogue HNG protected sperm-producing stem cells.

    Peptide
    Humanin
    Outcome
    IncreaseCP-induced suppression of spermatogonial stem cells after repeated CP doses
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    HNG rescued the CP-induced suppression of spermatogonial stem cells, sperm count and peripheral leucocytes.
    1 context sentence
    Summary · context
    To investigate whether HNG maintains its protective effects on spermatogonial stem cells, sperm output, and peripheral leucocytes after repeated doses of CP, normal adult male mice received: no treatment, daily sc injection of HNG, 6 ip injections of CP at 5-day intervals, and the same regimens of C…

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  8. 08AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In normal adult male mice given repeated cyclophosphamide doses, HNG rescued the suppression of sperm count.

    In plain wordsIn male mice given repeated cyclophosphamide doses, the humanin analogue HNG protected sperm count.

    Peptide
    Humanin
    Outcome
    IncreaseCP-induced suppression of sperm count after repeated CP doses
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    HNG rescued the CP-induced suppression of spermatogonial stem cells, sperm count and peripheral leucocytes.
    1 context sentence
    Summary · context
    To investigate whether HNG maintains its protective effects on spermatogonial stem cells, sperm output, and peripheral leucocytes after repeated doses of CP, normal adult male mice received: no treatment, daily sc injection of HNG, 6 ip injections of CP at 5-day intervals, and the same regimens of C…

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  9. 09AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In normal adult male mice given repeated cyclophosphamide doses, HNG rescued the suppression of peripheral leucocytes.

    In plain wordsIn male mice given repeated cyclophosphamide doses, the humanin analogue HNG protected white blood cell counts.

    Peptide
    Humanin
    Outcome
    IncreaseCP-induced suppression of peripheral leucocytes after repeated CP doses
    Study

    mousen: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    HNG rescued the CP-induced suppression of spermatogonial stem cells, sperm count and peripheral leucocytes.
    1 context sentence
    Summary · context
    To investigate whether HNG maintains its protective effects on spermatogonial stem cells, sperm output, and peripheral leucocytes after repeated doses of CP, normal adult male mice received: no treatment, daily sc injection of HNG, 6 ip injections of CP at 5-day intervals, and the same regimens of C…

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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