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Study · In vitro (cells) · 2015

16 results

The Effect of Thymosin β4 for Osteoblast Adhesion on Titanium Surface.

Choi BD, Jeong SJ, Lee HY, Lim DS, Lee BH, Bae CS, Jeong MJ

Journal of nanoscience and nanotechnology1 Aug 2015Cited by 4 (Europe PMC)

PMID26369135 (opens in a new tab)DOI10.1166/jnn.2015.10464 (opens in a new tab)PepBankPUB-26369135
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study16

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    Cell adhesion increased in Tβ4-treated MC3T3-E1 cells compared with untreated cells.

    In plain wordsIn cells, thymosin beta‑4 treatment increased bone cell adhesion compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseOsteoblast adhesion
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    cell adhesion and proliferation increased in the Tβ4 treated cells (Tβ4/MC3T3-E1)
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.
  2. 02LabIn vitro (cells)Efficacy outcome

    Cell proliferation increased in Tβ4-treated MC3T3-E1 cells compared with untreated cells.

    In plain wordsIn cells, thymosin beta‑4 treatment increased bone cell growth compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseOsteoblast proliferation
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    cell adhesion and proliferation increased in the Tβ4 treated cells (Tβ4/MC3T3-E1)
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.
  3. 03LabIn vitro (cells)Mechanism

    FAK phosphorylation was higher in Tβ4-treated cells than in untreated cells.

    In plain wordsIn cells, thymosin beta‑4 treatment raised FAK phosphorylation compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseFAK phosphorylation
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The levels of FAK phosphorylation, paxillin expression, and paxillin localization were higher in the Tβ4/IMC3T3-E1 cells than that of the untreated cells but lower in the si-Tβ4/MC3T3-E1 cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.
  4. 04LabIn vitro (cells)Mechanism

    Paxillin expression was higher in Tβ4-treated cells than in untreated cells.

    In plain wordsIn cells, thymosin beta‑4 treatment raised paxillin levels compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePaxillin expression
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The levels of FAK phosphorylation, paxillin expression, and paxillin localization were higher in the Tβ4/IMC3T3-E1 cells than that of the untreated cells but lower in the si-Tβ4/MC3T3-E1 cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.
  5. 05LabIn vitro (cells)Mechanism

    Paxillin localization was higher in Tβ4-treated cells than in untreated cells.

    In plain wordsIn cells, thymosin beta‑4 treatment raised paxillin localization compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePaxillin localization
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The levels of FAK phosphorylation, paxillin expression, and paxillin localization were higher in the Tβ4/IMC3T3-E1 cells than that of the untreated cells but lower in the si-Tβ4/MC3T3-E1 cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.
  6. 06LabIn vitro (cells)Mechanism

    Grb2 protein expression was higher in Tβ4-treated cells than in untreated cells.

    In plain wordsIn cells, thymosin beta‑4 treatment raised Grb2 levels compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseGrb2 expression
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, the levels of cell proliferation, Grb2 and Ras protein expression and phosphorylation of ERK1/2 were higher in the Tβ4/MC3T3-E1 cells than in the untreated cells but lower in the si-Tβ4/IMC3T3-E1 cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.
  7. 07LabIn vitro (cells)Mechanism

    Ras protein expression was higher in Tβ4-treated cells than in untreated cells.

    In plain wordsIn cells, thymosin beta‑4 treatment raised Ras levels compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseRas expression
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, the levels of cell proliferation, Grb2 and Ras protein expression and phosphorylation of ERK1/2 were higher in the Tβ4/MC3T3-E1 cells than in the untreated cells but lower in the si-Tβ4/IMC3T3-E1 cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.
  8. 08LabIn vitro (cells)Mechanism

    ERK1/2 phosphorylation was higher in Tβ4-treated cells than in untreated cells.

    In plain wordsIn cells, thymosin beta‑4 treatment raised ERK1/2 phosphorylation compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseERK1/2 phosphorylation
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, the levels of cell proliferation, Grb2 and Ras protein expression and phosphorylation of ERK1/2 were higher in the Tβ4/MC3T3-E1 cells than in the untreated cells but lower in the si-Tβ4/IMC3T3-E1 cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.

Studies that did not test the peptide alone8

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 09LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    Cell adhesion was significantly lower in Tβ4 knock-down cells than in untreated cells.

    In plain wordsIn cells, switching off thymosin beta‑4 production lowered bone cell adhesion compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseOsteoblast adhesion after Tβ4 knockdown
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    but was significantly lower in the Tβ4 knock-down cells by Tβ4-siRNA (si-Tβ4/MC3T3-E1) than that of the untreated cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 10LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    Cell proliferation was significantly lower in Tβ4 knock-down cells than in untreated cells.

    In plain wordsIn cells, switching off thymosin beta‑4 production lowered bone cell growth compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseOsteoblast proliferation after Tβ4 knockdown
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    but was significantly lower in the Tβ4 knock-down cells by Tβ4-siRNA (si-Tβ4/MC3T3-E1) than that of the untreated cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 11LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    FAK phosphorylation was lower in Tβ4 knock-down cells than in untreated cells.

    In plain wordsIn cells, switching off thymosin beta‑4 production lowered FAK phosphorylation compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseFAK phosphorylation after Tβ4 knockdown
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    The levels of FAK phosphorylation, paxillin expression, and paxillin localization were higher in the Tβ4/IMC3T3-E1 cells than that of the untreated cells but lower in the si-Tβ4/MC3T3-E1 cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 12LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    Paxillin expression was lower in Tβ4 knock-down cells than in untreated cells.

    In plain wordsIn cells, switching off thymosin beta‑4 production lowered paxillin levels compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreasePaxillin expression after Tβ4 knockdown
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    The levels of FAK phosphorylation, paxillin expression, and paxillin localization were higher in the Tβ4/IMC3T3-E1 cells than that of the untreated cells but lower in the si-Tβ4/MC3T3-E1 cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  5. 13LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    Paxillin localization was lower in Tβ4 knock-down cells than in untreated cells.

    In plain wordsIn cells, switching off thymosin beta‑4 production lowered paxillin localization compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreasePaxillin localization after Tβ4 knockdown
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    The levels of FAK phosphorylation, paxillin expression, and paxillin localization were higher in the Tβ4/IMC3T3-E1 cells than that of the untreated cells but lower in the si-Tβ4/MC3T3-E1 cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  6. 14LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    Grb2 protein expression was lower in Tβ4 knock-down cells than in untreated cells.

    In plain wordsIn cells, switching off thymosin beta‑4 production lowered Grb2 levels compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseGrb2 expression after Tβ4 knockdown
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    In addition, the levels of cell proliferation, Grb2 and Ras protein expression and phosphorylation of ERK1/2 were higher in the Tβ4/MC3T3-E1 cells than in the untreated cells but lower in the si-Tβ4/IMC3T3-E1 cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  7. 15LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    Ras protein expression was lower in Tβ4 knock-down cells than in untreated cells.

    In plain wordsIn cells, switching off thymosin beta‑4 production lowered Ras levels compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseRas expression after Tβ4 knockdown
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    In addition, the levels of cell proliferation, Grb2 and Ras protein expression and phosphorylation of ERK1/2 were higher in the Tβ4/MC3T3-E1 cells than in the untreated cells but lower in the si-Tβ4/IMC3T3-E1 cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  8. 16LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    ERK1/2 phosphorylation was lower in Tβ4 knock-down cells than in untreated cells.

    In plain wordsIn cells, switching off thymosin beta‑4 production lowered ERK1/2 phosphorylation compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseERK1/2 phosphorylation after Tβ4 knockdown
    Study

    n: not reported in source

    MC3T3-E1 osteoblast cells
    Comparator
    Untreated cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    In addition, the levels of cell proliferation, Grb2 and Ras protein expression and phosphorylation of ERK1/2 were higher in the Tβ4/MC3T3-E1 cells than in the untreated cells but lower in the si-Tβ4/IMC3T3-E1 cells.
    1 context sentence
    Summary · context
    This study examined the role of Tβ4 in osteoblasts via focal adhesions (FAs) and ERK1/2 signaling related to cell adhesion and proliferation for cell survival on the Ti surface.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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