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Study · Not a test of the peptide alone · 2015

5 results

Peptide fragment of thymosin β4 increases hippocampal neurogenesis and facilitates spatial memory.

Kim DH, Moon EY, Yi JH, Lee HE, Park SJ, Ryu YK, Kim HC, Lee S, Ryu JH

Neuroscience9 Sept 2015Cited by 16 (Europe PMC)

PMID26363149 (opens in a new tab)DOI10.1016/j.neuroscience.2015.09.017 (opens in a new tab)PepBankPUB-26363149
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    Intrahippocampal infusion of Ac-SDKP, a Tβ4 fragment, facilitated the generation of new neurons in the hippocampus.

    In plain wordsIn mice, a fragment of thymosin beta‑4 infused into the hippocampus increased new nerve cell formation.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseHippocampal neurogenesis
    Study

    mousen: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Intrahippocampal infusion of Ac-SDKP facilitated the generation of new neurons in the hippocampus.
    1 context sentence
    Summary · context
    Here, we examined neurogenesis-stimulative effect of Ac-SDKP.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    Ac-SDKP, a Tβ4 fragment, increased β-catenin stability in the mouse hippocampus.

    In plain wordsIn mice, a fragment of thymosin beta‑4 made β-catenin more stable in the hippocampus.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Increaseβ-catenin stability in hippocampus
    Study

    mousen: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    an increase in β-catenin stability with reduction of glycogen synthase kinase-3β (GSK-3β) activity.
    1 context sentence
    Summary · context
    Here, we examined neurogenesis-stimulative effect of Ac-SDKP.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    Ac-SDKP, a Tβ4 fragment, reduced GSK-3β activity in the mouse hippocampus.

    In plain wordsIn mice, a fragment of thymosin beta‑4 lowered GSK-3β activity in the hippocampus.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseGSK-3β activity in hippocampus
    Study

    mousen: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Ac-SDKP-treated mouse hippocampus showed an increase in β-catenin stability with reduction of glycogen synthase kinase-3β (GSK-3β) activity.
    1 context sentence
    Summary · context
    Here, we examined neurogenesis-stimulative effect of Ac-SDKP.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    Inhibition of VEGF signaling blocked the neural proliferation facilitated by Ac-SDKP.

    In plain wordsIn mice, blocking VEGF signaling stopped the nerve cell growth caused by a fragment of thymosin beta‑4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseAc-SDKP-facilitated neural proliferation with VEGF signaling inhibition
    Study

    mousen: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Moreover, inhibition of vascular endothelial growth factor (VEGF) signaling blocked Ac-SDKP-facilitated neural proliferation.
    1 context sentence
    Summary · context
    Here, we examined neurogenesis-stimulative effect of Ac-SDKP.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  5. 05AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    Subchronic intrahippocampal infusion of Ac-SDKP, a Tβ4 fragment, increased spatial memory.

    In plain wordsIn mice, repeated infusion of a fragment of thymosin beta‑4 into the hippocampus improved spatial memory.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSpatial memory
    Study

    mousen: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    Subchronic intrahippocampal infusion of Ac-SDKP also increased spatial memory.
    1 context sentence
    Summary · context
    Here, we examined neurogenesis-stimulative effect of Ac-SDKP.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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