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Study · Animal study (in vivo) · mouse · 2015

2 results

Chronic Exposure of Female Mice to an Environmental Level of Perfluorooctane Sulfonate Suppresses Estrogen Synthesis Through Reduced Histone H3K14 Acetylation of the StAR Promoter Leading to Deficits in Follicular Development and Ovulation.

Feng X, Wang X, Cao X, Xia Y, Zhou R, Chen L

Toxicological sciences : an official journal of the Society of Toxicology9 Sept 2015Cited by 96 (Europe PMC)

PMID26358002 (opens in a new tab)DOI10.1093/toxsci/kfv197 (opens in a new tab)PepBankPUB-26358002
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In PFOS-exposed female mice that produced no LH surge at proestrus, kisspeptin‑10 (or estradiol) rescued the LH surge.

    In plain wordsIn female mice exposed to PFOS, kisspeptin‑10 restored the missing LH surge at proestrus, as estradiol did.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH surge at proestrus in PFOS-exposed mice
    Study

    Mousen: not reported in source

    Adult female mice exposed to PFOS for 4 months
    Comparator
    PFOS-mice without rescue
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PFOS-mice did not generate an LH-surge at proestrus, which could be rescued by the application of E2 or kisspeptin-10.
    1 context sentence
    Summary · context
    Herein, we show that adult female mice exposed to PFOS by gavage for 4 months (PFOS-mice) exhibited a prolongation of diestrus without signs of toxic effects.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In female mice, chronic PFOS exposure reduced the number of kisspeptin neurons and the level of kiss1 mRNA in the anteroventral periventricular nucleus at proestrus but not at diestrus.

    In plain wordsIn female mice, PFOS exposure lowered the body's own kisspeptin neurons and kiss1 gene activity in a brain area at proestrus.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKisspeptin neurons and kiss1 mRNA in the AVPV with PFOS
    Study

    Mousen: not reported in source

    Adult female mice exposed to PFOS for 4 months
    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In comparison with controls, PFOS-mice showed a significant decrease in the levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), and gonadotrophin-releasing hormone, the number of kisspeptin neurons and the level of kiss1 mRNA in anteroventral periventricular nucleus at proestr…
    1 context sentence
    Summary · context
    Herein, we show that adult female mice exposed to PFOS by gavage for 4 months (PFOS-mice) exhibited a prolongation of diestrus without signs of toxic effects.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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