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Study · Animal study (in vivo) · mouse · 2016

3 results

Blast traumatic brain injury-induced cognitive deficits are attenuated by preinjury or postinjury treatment with the glucagon-like peptide-1 receptor agonist, exendin-4.

Tweedie D, Rachmany L, Rubovitch V, Li Y, Holloway HW, Lehrmann E, Zhang Y, Becker KG, Perez E, Hoffer BJ, Pick CG, Greig NH

Alzheimer's & dementia : the journal of the Alzheimer's Association29 Aug 2015Cited by 50 (Europe PMC)

PMID26327236 (opens in a new tab)PMCIDPMC4715981 (opens in a new tab)DOI10.1016/j.jalz.2015.07.489 (opens in a new tab)PepBankPUB-26327236
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, preinjury or postinjury exendin‑4 reduced blast-induced neurodegeneration at 72 hours.

    In plain wordsIn mice, exendin‑4 before or after blast injury reduced nerve degeneration at 72 hours.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseNeurodegeneration
    Study

    mousen: not reported in source

    blast traumatic brain injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    Ex-4, administered preinjury or postinjury, ameliorated B-TBI-induced neurodegeneration at 72 hours, memory deficits from days 7-14, and attenuated genes regulated by blast at day 14 postinjury.
    1 context sentence
    Summary · context
    Exendin-4 (Ex-4), administered subcutaneously, was evaluated as a pretreatment (48 hours) and postinjury treatment (2 hours) on neurodegeneration, behaviors, and gene expressions in a murine open field model of blast injury.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, preinjury or postinjury exendin‑4 reduced blast-induced memory deficits from days 7-14.

    In plain wordsIn mice, exendin‑4 before or after blast injury reduced memory deficits from days 7-14.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMemory deficits
    Study

    mousen: not reported in source

    blast traumatic brain injury
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    Ex-4, administered preinjury or postinjury, ameliorated B-TBI-induced neurodegeneration at 72 hours, memory deficits from days 7-14, and attenuated genes regulated by blast at day 14 postinjury.
    1 context sentence
    Summary · context
    Exendin-4 (Ex-4), administered subcutaneously, was evaluated as a pretreatment (48 hours) and postinjury treatment (2 hours) on neurodegeneration, behaviors, and gene expressions in a murine open field model of blast injury.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, preinjury or postinjury exendin‑4 attenuated blast-regulated gene expression at day 14 after injury.

    In plain wordsIn mice, exendin‑4 before or after blast injury reduced changes in gene expression at day 14.

    Peptide
    Exenatide (exendin-4)
    Outcome
    MixedBlast-regulated gene expression
    Study

    mousen: not reported in source

    blast traumatic brain injury
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    Ex-4, administered preinjury or postinjury, ameliorated B-TBI-induced neurodegeneration at 72 hours, memory deficits from days 7-14, and attenuated genes regulated by blast at day 14 postinjury.
    1 context sentence
    Summary · context
    Exendin-4 (Ex-4), administered subcutaneously, was evaluated as a pretreatment (48 hours) and postinjury treatment (2 hours) on neurodegeneration, behaviors, and gene expressions in a murine open field model of blast injury.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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