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Study · Animal study (in vivo) · rat · 2015

7 results

Plasma carnosine, but not muscle carnosine, attenuates high-fat diet-induced metabolic stress.

Stegen S, Stegen B, Aldini G, Altomare A, Cannizzaro L, Orioli M, Gerlo S, Deldicque L, Ramaekers M, Hespel P, Derave W

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme1 Sept 2015Cited by 20 (Europe PMC)

PMID26307517 (opens in a new tab)DOI10.1139/apnm-2015-0042 (opens in a new tab)PepBankPUB-26307517
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the high-fat diet with carnosine group was significantly heavier than the control diet group, as were all high-fat groups.

    In plain wordsIn rats, all high-fat groups, including the carnosine group, were significantly heavier than the control diet group.

    Peptide
    L-carnosine
    Outcome
    IncreaseBody weight versus control diet
    Study

    ratn: not reported in source

    High-fat diet in male Sprague-Dawley rats
    Comparator
    Control diet group
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1.8% carnosine in diet · oralAs given in this study (rat).

    Source sentences

    Summary
    The 3 HF groups were significantly heavier than the CON group.
    2 context sentences
    Summary · context
    This was investigated using oral carnosine versus β-alanine supplementation in a high-fat diet rat model.
    Summary · context
    Thirty-six male Sprague-Dawley rats received a control diet (CON), a high-fat diet (HF; 60% of energy from fat), the HF diet with 1.8% carnosine (HFcar), or the HF diet with 1% β-alanine (HFba), as β-alanine can increase muscle carnosine without increasing plasma carnosine.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In high-fat-fed rats, muscle carnosine increased equally with carnosine and β-alanine supplementation.

    In plain wordsIn high-fat-fed rats, muscle carnosine increased equally with carnosine and β-alanine supplementation.

    Peptide
    L-carnosine
    Outcome
    IncreaseMuscle carnosine
    Study

    ratn: not reported in source

    High-fat diet in male Sprague-Dawley rats
    Comparator
    High-fat diet with β-alanine
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1.8% carnosine in diet · oralAs given in this study (rat).

    Source sentences

    Summary
    Muscle carnosine concentrations increased equally in the HFcar and HFba groups, while elevated plasma carnosine levels and carnosine-4-hydroxy-2-nonenal adducts were detected only in the HFcar group.
    2 context sentences
    Summary · context
    This was investigated using oral carnosine versus β-alanine supplementation in a high-fat diet rat model.
    Summary · context
    Thirty-six male Sprague-Dawley rats received a control diet (CON), a high-fat diet (HF; 60% of energy from fat), the HF diet with 1.8% carnosine (HFcar), or the HF diet with 1% β-alanine (HFba), as β-alanine can increase muscle carnosine without increasing plasma carnosine.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In high-fat-fed rats, elevated plasma carnosine was detected only in the carnosine-supplemented group.

    In plain wordsIn high-fat-fed rats, elevated plasma carnosine appeared only in the carnosine-supplemented group.

    Peptide
    L-carnosine
    Outcome
    IncreasePlasma carnosine
    Study

    ratn: not reported in source

    High-fat diet in male Sprague-Dawley rats
    Comparator
    Other diet groups
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1.8% carnosine in diet · oralAs given in this study (rat).

    Source sentences

    Summary
    Muscle carnosine concentrations increased equally in the HFcar and HFba groups, while elevated plasma carnosine levels and carnosine-4-hydroxy-2-nonenal adducts were detected only in the HFcar group.
    2 context sentences
    Summary · context
    This was investigated using oral carnosine versus β-alanine supplementation in a high-fat diet rat model.
    Summary · context
    Thirty-six male Sprague-Dawley rats received a control diet (CON), a high-fat diet (HF; 60% of energy from fat), the HF diet with 1.8% carnosine (HFcar), or the HF diet with 1% β-alanine (HFba), as β-alanine can increase muscle carnosine without increasing plasma carnosine.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In high-fat-fed rats, carnosine-4-hydroxy-2-nonenal adducts were detected only in the carnosine-supplemented group.

    In plain wordsIn high-fat-fed rats, carnosine-4-hydroxy-2-nonenal reaction products appeared only in the carnosine-supplemented group.

    Peptide
    L-carnosine
    Outcome
    Not applicableCarnosine-4-hydroxy-2-nonenal adduct detection
    Study

    ratn: not reported in source

    High-fat diet in male Sprague-Dawley rats
    Comparator
    Other diet groups
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1.8% carnosine in diet · oralAs given in this study (rat).

    Source sentences

    Summary
    Muscle carnosine concentrations increased equally in the HFcar and HFba groups, while elevated plasma carnosine levels and carnosine-4-hydroxy-2-nonenal adducts were detected only in the HFcar group.
    2 context sentences
    Summary · context
    This was investigated using oral carnosine versus β-alanine supplementation in a high-fat diet rat model.
    Summary · context
    Thirty-six male Sprague-Dawley rats received a control diet (CON), a high-fat diet (HF; 60% of energy from fat), the HF diet with 1.8% carnosine (HFcar), or the HF diet with 1% β-alanine (HFba), as β-alanine can increase muscle carnosine without increasing plasma carnosine.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In high-fat-fed rats, carnosine reduced elevated plasma carboxymethyllysine by approximately 50% compared with unsupplemented high-fat-fed rats.

    In plain wordsIn high-fat-fed rats, carnosine reduced elevated plasma carboxymethyllysine by approximately 50% compared with unsupplemented rats.

    Peptide
    L-carnosine
    Outcome
    DecreasePlasma carboxymethyllysine
    Study

    ratn: not reported in source

    High-fat diet in male Sprague-Dawley rats
    Comparator
    High-fat diet rats
    Outcome group
    Inflammation markers · Metabolic and weight
    Studied dose
    1.8% carnosine in diet · oralAs given in this study (rat).

    Source sentences

    Summary
    Elevated plasma and urine N(ε)-(carboxymethyl)lysine in HF rats was reduced by ∼50% in the HFcar group but not in the HFba group.
    2 context sentences
    Summary · context
    This was investigated using oral carnosine versus β-alanine supplementation in a high-fat diet rat model.
    Summary · context
    Thirty-six male Sprague-Dawley rats received a control diet (CON), a high-fat diet (HF; 60% of energy from fat), the HF diet with 1.8% carnosine (HFcar), or the HF diet with 1% β-alanine (HFba), as β-alanine can increase muscle carnosine without increasing plasma carnosine.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In high-fat-fed rats, carnosine reduced elevated urinary carboxymethyllysine by approximately 50% compared with unsupplemented high-fat-fed rats.

    In plain wordsIn high-fat-fed rats, carnosine reduced elevated urinary carboxymethyllysine by approximately 50% compared with unsupplemented rats.

    Peptide
    L-carnosine
    Outcome
    DecreaseUrinary carboxymethyllysine
    Study

    ratn: not reported in source

    High-fat diet in male Sprague-Dawley rats
    Comparator
    High-fat diet rats
    Outcome group
    Inflammation markers · Metabolic and weight
    Studied dose
    1.8% carnosine in diet · oralAs given in this study (rat).

    Source sentences

    Summary
    Elevated plasma and urine N(ε)-(carboxymethyl)lysine in HF rats was reduced by ∼50% in the HFcar group but not in the HFba group.
    2 context sentences
    Summary · context
    This was investigated using oral carnosine versus β-alanine supplementation in a high-fat diet rat model.
    Summary · context
    Thirty-six male Sprague-Dawley rats received a control diet (CON), a high-fat diet (HF; 60% of energy from fat), the HF diet with 1.8% carnosine (HFcar), or the HF diet with 1% β-alanine (HFba), as β-alanine can increase muscle carnosine without increasing plasma carnosine.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In high-fat-fed rats, carnosine decreased inducible nitric oxide synthase mRNA by 47% compared with unsupplemented high-fat-fed rats.

    In plain wordsIn high-fat-fed rats, carnosine decreased inducible nitric oxide synthase mRNA by 47% compared with unsupplemented rats.

    Peptide
    L-carnosine
    Outcome
    DecreaseInducible nitric oxide synthase mRNA
    Study

    ratn: not reported in source

    High-fat diet in male Sprague-Dawley rats
    Comparator
    High-fat diet rats
    Outcome group
    Inflammation markers · Metabolic and weight
    Studied dose
    1.8% carnosine in diet · oralAs given in this study (rat).

    Measurements

    iNOS mRNA reduction
    47%
    versus HF rats

    Source sentences

    Summary
    Likewise, inducible nitric oxide synthase mRNA was decreased by 47% (p < 0.05) in the HFcar group, but not in the HFba group, compared with HF rats.
    2 context sentences
    Summary · context
    This was investigated using oral carnosine versus β-alanine supplementation in a high-fat diet rat model.
    Summary · context
    Thirty-six male Sprague-Dawley rats received a control diet (CON), a high-fat diet (HF; 60% of energy from fat), the HF diet with 1.8% carnosine (HFcar), or the HF diet with 1% β-alanine (HFba), as β-alanine can increase muscle carnosine without increasing plasma carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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