Teduglutide-Stimulated Intestinal Adaptation Is Complemented and Synergistically Enhanced by Partial Enteral Nutrition in a Neonatal Piglet Model of Short Bowel Syndrome.

Naberhuis JK, Deutsch AS, Tappenden KA

JPEN. Journal of parenteral and enteral nutrition24 Aug 2015Cited by 19 (Europe PMC)

PMID26304601DOI10.1177/0148607115602891PepBankPUB-26304601

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study17

17 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved duodenal villus height (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved duodenal villus height versus control.
Peptide
Teduglutide
Outcome
IncreaseDuodenal villus height
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460101
02AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved jejunal villus height (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved jejunal villus height versus control.
Peptide
Teduglutide
Outcome
IncreaseJejunal villus height
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460102
03AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved ileal villus height (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved ileal villus height versus control.
Peptide
Teduglutide
Outcome
IncreaseIleal villus height
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460103
04AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved ileal crypt depth (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved ileal crypt depth versus control.
Peptide
Teduglutide
Outcome
IncreaseIleal crypt depth
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460104
05AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved colonic crypt depth (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved colonic crypt depth versus control.
Peptide
Teduglutide
Outcome
IncreaseColonic crypt depth
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460105
06AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved duodenal proliferation (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved duodenal cell proliferation versus control.
Peptide
Teduglutide
Outcome
IncreaseDuodenal proliferation
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460106
07AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved jejunal proliferation (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved jejunal cell proliferation versus control.
Peptide
Teduglutide
Outcome
IncreaseJejunal proliferation
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460107
08AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved ileal proliferation (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved ileal cell proliferation versus control.
Peptide
Teduglutide
Outcome
IncreaseIleal proliferation
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460108
09AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved colonic proliferation (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved colonic cell proliferation versus control.
Peptide
Teduglutide
Outcome
IncreaseColonic proliferation
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460109
10AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved jejunal apoptosis measures (P < .05) versus control, without a stated numeric direction.
In plain wordsIn piglets with SBS, teduglutide improved jejunal apoptosis measures versus control. The abstract does not state their numeric direction.
Peptide
Teduglutide
Outcome
Direction not reportedJejunal apoptosis
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460110
11AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved ileal apoptosis measures (P < .05) versus control, without a stated numeric direction.
In plain wordsIn piglets with SBS, teduglutide improved ileal apoptosis measures versus control. The abstract does not state their numeric direction.
Peptide
Teduglutide
Outcome
Direction not reportedIleal apoptosis
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460111
12AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved colonic apoptosis measures (P < .05) versus control, without a stated numeric direction.
In plain wordsIn piglets with SBS, teduglutide improved colonic apoptosis measures versus control. The abstract does not state their numeric direction.
Peptide
Teduglutide
Outcome
Direction not reportedColonic apoptosis
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460112
13AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved acute duodenal glucose processing capacity (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved duodenal glucose processing versus control.
Peptide
Teduglutide
Outcome
IncreaseDuodenal glucose processing
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460113
14AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved acute jejunal glucose processing capacity (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved jejunal glucose processing versus control.
Peptide
Teduglutide
Outcome
IncreaseJejunal glucose processing
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460114
15AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved acute ileal glucose processing capacity (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved ileal glucose processing versus control.
Peptide
Teduglutide
Outcome
IncreaseIleal glucose processing
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460115
16AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved acute duodenal glutamine processing capacity (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved duodenal glutamine processing versus control.
Peptide
Teduglutide
Outcome
IncreaseDuodenal glutamine processing
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460116
17AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, teduglutide improved acute jejunal glutamine processing capacity (P < .05) versus control.
In plain wordsIn piglets with SBS, teduglutide improved jejunal glutamine processing versus control.
Peptide
Teduglutide
Outcome
IncreaseJejunal glutamine processing
Study
pign: not reported in source
Neonatal piglet short bowel syndrome
Comparator
Control in factorial nutrition design
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 mg/kg/dAs given in this study (pig).
Source sentences
Summary
Teduglutide improved ( P < .05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum; colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum).
1 context sentence(design, population, supporting numbers)
Summary · context
Neonatal piglets (48 hours old; n = 72) underwent an 80% jejunoileal resection and were randomized to 1 of 4 treatment groups, in a 2 × 2 factorial design, with PN or PEN (80% standard PN/20% standard enteral nutrition) and teduglutide (0.1 mg/kg/d) or control.
Report a problemFND-2630460117

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.

Teduglutide-Stimulated Intestinal Adaptation Is Complemented and Synergistically Enhanced by Partial Enteral Nutrition in a Neonatal Piglet Model of Short Bowel Syndrome.

Summary

Results from this study17

Version history

Subjects

Publication types

MeSH terms

Keywords