In horses with early osteochondrosis lesions, thymosin β4 (TMSB4) gene expression was higher in lesion cartilage than in control cartilage.
In plain wordsIn horses, the gene for the body's own thymosin β4 was more active in cartilage with early joint lesions than in healthy cartilage.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- IncreaseTMSB4 expression in osteochondrosis lesions
- Study
horsen: not reported in source
Equine osteochondrosis lesions- Comparator
- Control cartilage
- Outcome group
- Bone and joint · Musculoskeletal
Source sentences
Genes encoding vacuolar H(+)-ATPase V0 subunit d2 (ATP6V0D2), cathepsin K, integrin-binding sialoprotein, integrin αV, low density lipoprotein receptor-related protein 4, lumican, osteopontin, and thymosin β4 (TMSB4) were expressed at higher levels in lesions than in control cartilage.
2 context sentences(design, population, supporting numbers)
Differential expression of ATP6V0D2 and TMSB4 in the cartilage of early naturally occurring osteochondrosis lesions was confirmed by immunohistochemistry.
A subtractive hybridization study was undertaken to compare gene expression between the cartilage of early experimentally induced equine osteochondrosis lesions and control cartilage.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.