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Study · Animal study (in vivo) · 2015

1 result

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure.

Nickel AG, von Hardenberg A, Hohl M, Löffler JR, Kohlhaas M, Becker J, Reil JC, Kazakov A, Bonnekoh J, Stadelmaier M, Puhl SL, Wagner M and 18 more

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Bogeski I, Cortassa S, Kappl R, Pasieka B, Lafontaine M, Lancaster CR, Blacker TS, Hall AR, Duchen MR, Kästner L, Lipp P, Zeller T, Müller C, Knopp A, Laufs U, Böhm M, Hoth M, Maack C

Cell metabolism6 Aug 2015Cited by 328 (Europe PMC)

PMID26256392 (opens in a new tab)DOI10.1016/j.cmet.2015.07.008 (opens in a new tab)PepBankPUB-26256392
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animals with pressure overload-induced heart failure, SS‑31 rescued mortality.

    In plain wordsIn animals with heart failure from pressure overload, SS‑31 improved survival.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMortality in pressure overload-induced heart failure
    Study

    n: not reported in source

    Pressure overload-induced heart failure
    Outcome group
    Mortality · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Targeting Nnt-mediated ROS with the tetrapeptide SS-31 rescued mortality in pressure overload-induced heart failure and could therefore have therapeutic potential in patients with this syndrome.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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