Protective effect of bioactive peptide carnosine against lead-induced oxidative stress in kidney of rats.

Hasanein P, Teimuri-Far M

Cellular and molecular biology (Noisy-le-Grand, France)5 Aug 2015Cited by 4 (Europe PMC)

PMID26255262PepBankPUB-26255262

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In lead-exposed and control rats, carnosine decreased renal MDA content.
In plain wordsIn lead-exposed and control rats, carnosine decreased kidney MDA content.
Peptide
L-carnosine
Outcome
DecreaseRenal MDA
Study
ratn: not reported in source
Lead exposure and control rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 mg/kg · intragastric · eight weeksAs given in this study (rat).
Source sentences
Summary
Carnosine treatment decreased MDA whereas it increased the contents of GSH, TAC, CAT and SOD in both lead and control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or carnosine (10 mg/kg, i.g.) for eight weeks.
Report a problemFND-2625526201
02AnimalAnimal study (in vivo)Mechanism
In lead-exposed and control rats, carnosine increased renal GSH content.
In plain wordsIn lead-exposed and control rats, carnosine increased kidney GSH content.
Peptide
L-carnosine
Outcome
IncreaseRenal GSH
Study
ratn: not reported in source
Lead exposure and control rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 mg/kg · intragastric · eight weeksAs given in this study (rat).
Source sentences
Summary
Carnosine treatment decreased MDA whereas it increased the contents of GSH, TAC, CAT and SOD in both lead and control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or carnosine (10 mg/kg, i.g.) for eight weeks.
Report a problemFND-2625526202
03AnimalAnimal study (in vivo)Mechanism
In lead-exposed and control rats, carnosine increased renal total antioxidant capacity.
In plain wordsIn lead-exposed and control rats, carnosine increased kidney total antioxidant capacity.
Peptide
L-carnosine
Outcome
IncreaseRenal total antioxidant capacity
Study
ratn: not reported in source
Lead exposure and control rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 mg/kg · intragastric · eight weeksAs given in this study (rat).
Source sentences
Summary
Carnosine treatment decreased MDA whereas it increased the contents of GSH, TAC, CAT and SOD in both lead and control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or carnosine (10 mg/kg, i.g.) for eight weeks.
Report a problemFND-2625526203
04AnimalAnimal study (in vivo)Mechanism
In lead-exposed and control rats, carnosine increased renal catalase content.
In plain wordsIn lead-exposed and control rats, carnosine increased kidney catalase content.
Peptide
L-carnosine
Outcome
IncreaseRenal catalase
Study
ratn: not reported in source
Lead exposure and control rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 mg/kg · intragastric · eight weeksAs given in this study (rat).
Source sentences
Summary
Carnosine treatment decreased MDA whereas it increased the contents of GSH, TAC, CAT and SOD in both lead and control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or carnosine (10 mg/kg, i.g.) for eight weeks.
Report a problemFND-2625526204
05AnimalAnimal study (in vivo)Mechanism
In lead-exposed and control rats, carnosine increased renal superoxide dismutase content.
In plain wordsIn lead-exposed and control rats, carnosine increased kidney superoxide dismutase content.
Peptide
L-carnosine
Outcome
IncreaseRenal superoxide dismutase
Study
ratn: not reported in source
Lead exposure and control rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 mg/kg · intragastric · eight weeksAs given in this study (rat).
Source sentences
Summary
Carnosine treatment decreased MDA whereas it increased the contents of GSH, TAC, CAT and SOD in both lead and control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or carnosine (10 mg/kg, i.g.) for eight weeks.
Report a problemFND-2625526205
06AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented the increase in kidney weight.
In plain wordsIn lead-exposed rats, carnosine prevented the increase in kidney weight.
Peptide
L-carnosine
Outcome
DecreaseKidney weight
Study
ratn: not reported in source
Lead exposure and control rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 mg/kg · intragastric · eight weeksAs given in this study (rat).
Source sentences
Summary
Carnosine prevented the increased kidney weight and lead-induced deleterious effects on serum creatinine, urea, uric acid, albumin and total protein in lead group.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or carnosine (10 mg/kg, i.g.) for eight weeks.
Report a problemFND-2625526206
07AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented deleterious effects on serum creatinine, without a stated direction.
In plain wordsIn lead-exposed rats, carnosine prevented harmful changes in serum creatinine. The abstract does not state the direction.
Peptide
L-carnosine
Outcome
Direction not reportedSerum creatinine disturbance
Study
ratn: not reported in source
Lead exposure and control rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 mg/kg · intragastric · eight weeksAs given in this study (rat).
Source sentences
Summary
Carnosine prevented the increased kidney weight and lead-induced deleterious effects on serum creatinine, urea, uric acid, albumin and total protein in lead group.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or carnosine (10 mg/kg, i.g.) for eight weeks.
Report a problemFND-2625526207
08AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented deleterious effects on serum urea, without a stated direction.
In plain wordsIn lead-exposed rats, carnosine prevented harmful changes in serum urea. The abstract does not state the direction.
Peptide
L-carnosine
Outcome
Direction not reportedSerum urea disturbance
Study
ratn: not reported in source
Lead exposure and control rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 mg/kg · intragastric · eight weeksAs given in this study (rat).
Source sentences
Summary
Carnosine prevented the increased kidney weight and lead-induced deleterious effects on serum creatinine, urea, uric acid, albumin and total protein in lead group.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or carnosine (10 mg/kg, i.g.) for eight weeks.
Report a problemFND-2625526208
09AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented deleterious effects on serum uric acid, without a stated direction.
In plain wordsIn lead-exposed rats, carnosine prevented harmful changes in serum uric acid. The abstract does not state the direction.
Peptide
L-carnosine
Outcome
Direction not reportedSerum uric acid disturbance
Study
ratn: not reported in source
Lead exposure and control rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 mg/kg · intragastric · eight weeksAs given in this study (rat).
Source sentences
Summary
Carnosine prevented the increased kidney weight and lead-induced deleterious effects on serum creatinine, urea, uric acid, albumin and total protein in lead group.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or carnosine (10 mg/kg, i.g.) for eight weeks.
Report a problemFND-2625526209
10AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented deleterious effects on serum albumin, without a stated direction.
In plain wordsIn lead-exposed rats, carnosine prevented harmful changes in serum albumin. The abstract does not state the direction.
Peptide
L-carnosine
Outcome
Direction not reportedSerum albumin disturbance
Study
ratn: not reported in source
Lead exposure and control rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 mg/kg · intragastric · eight weeksAs given in this study (rat).
Source sentences
Summary
Carnosine prevented the increased kidney weight and lead-induced deleterious effects on serum creatinine, urea, uric acid, albumin and total protein in lead group.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or carnosine (10 mg/kg, i.g.) for eight weeks.
Report a problemFND-2625526210
11AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine prevented deleterious effects on serum total protein, without a stated direction.
In plain wordsIn lead-exposed rats, carnosine prevented harmful changes in serum total protein. The abstract does not state the direction.
Peptide
L-carnosine
Outcome
Direction not reportedSerum total protein disturbance
Study
ratn: not reported in source
Lead exposure and control rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 mg/kg · intragastric · eight weeksAs given in this study (rat).
Source sentences
Summary
Carnosine prevented the increased kidney weight and lead-induced deleterious effects on serum creatinine, urea, uric acid, albumin and total protein in lead group.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or carnosine (10 mg/kg, i.g.) for eight weeks.
Report a problemFND-2625526211
12AnimalAnimal study (in vivo)Efficacy outcome
In lead-exposed rats, carnosine attenuated abnormal renal structure.
In plain wordsIn lead-exposed rats, carnosine reduced abnormal kidney structure.
Peptide
L-carnosine
Outcome
DecreaseAbnormal renal structure
Study
ratn: not reported in source
Lead exposure and control rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 mg/kg · intragastric · eight weeksAs given in this study (rat).
Source sentences
Summary
It also attenuated lead induced abnormal renal structure.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or carnosine (10 mg/kg, i.g.) for eight weeks.
Report a problemFND-2625526212

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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