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Study · Animal study (in vivo) · 2016

12 results

Protective Effects of Antioxidant Peptide SS-31 Against Multiple Organ Dysfunctions During Endotoxemia.

Li G, Wu J, Li R, Yuan D, Fan Y, Yang J, Ji M, Zhu S

Inflammation1 Feb 2016Cited by 25 (Europe PMC)

PMID26231114 (opens in a new tab)DOI10.1007/s10753-015-0222-1 (opens in a new tab)PepBankPUB-26231114
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animals with cecal ligation and puncture sepsis, SS‑31 treatment decreased histological scores of organ injury versus vehicle.

    In plain wordsIn animals with sepsis, SS‑31 treatment lowered tissue damage scores in organs compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHistological scores of organ injury
    Study

    n: not reported in source

    cecal ligation and puncture (CLP) sepsis
    Comparator
    Vehicle
    Outcome group
    Organ injury · Whole body
    Studied dose
    5 mg/kg · intraperitoneal · immediately and at 5 h after the operationAs given in this study.

    Source sentences

    Summary
    decreased histological scores
    2 context sentences
    Summary · context
    Sepsis was induced by cecal ligation and puncture.
    Summary · context
    Immediately and at 5 h after the operation, SS-31 (5 mg/kg) or vehicle was administered intraperitoneally.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In animals with cecal ligation and puncture sepsis, SS‑31 treatment increased arterial partial oxygen tension versus vehicle.

    In plain wordsIn animals with sepsis, SS‑31 treatment raised blood oxygen levels compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseArterial partial oxygen tension
    Study

    n: not reported in source

    cecal ligation and puncture (CLP) sepsis
    Comparator
    Vehicle
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    5 mg/kg · intraperitoneal · immediately and at 5 h after the operationAs given in this study.

    Source sentences

    Summary
    increased arterial partial oxygen tension, and deceased serum alanine aminotransferase, urea nitrogen, and creatinine levels, which was accompanied by decreased levels of malondialdehyde, tumor necrosis factor-alpha, pulmonary myeloperoxidase activity, nuclear factor kappa B p65, inducible nitric ox…
    2 context sentences
    Summary · context
    Sepsis was induced by cecal ligation and puncture.
    Summary · context
    Immediately and at 5 h after the operation, SS-31 (5 mg/kg) or vehicle was administered intraperitoneally.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In animals with cecal ligation and puncture sepsis, SS‑31 treatment decreased serum alanine aminotransferase versus vehicle.

    In plain wordsIn animals with sepsis, SS‑31 treatment lowered a blood marker of liver injury (ALT) compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseSerum alanine aminotransferase
    Study

    n: not reported in source

    cecal ligation and puncture (CLP) sepsis
    Comparator
    Vehicle
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    5 mg/kg · intraperitoneal · immediately and at 5 h after the operationAs given in this study.

    Source sentences

    Summary
    deceased serum alanine aminotransferase, urea nitrogen, and creatinine levels
    2 context sentences
    Summary · context
    Sepsis was induced by cecal ligation and puncture.
    Summary · context
    Immediately and at 5 h after the operation, SS-31 (5 mg/kg) or vehicle was administered intraperitoneally.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In animals with cecal ligation and puncture sepsis, SS‑31 treatment decreased serum urea nitrogen versus vehicle.

    In plain wordsIn animals with sepsis, SS‑31 treatment lowered a blood marker of kidney injury (urea nitrogen) compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseSerum urea nitrogen
    Study

    n: not reported in source

    cecal ligation and puncture (CLP) sepsis
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    5 mg/kg · intraperitoneal · immediately and at 5 h after the operationAs given in this study.

    Source sentences

    Summary
    deceased serum alanine aminotransferase, urea nitrogen, and creatinine levels
    2 context sentences
    Summary · context
    Sepsis was induced by cecal ligation and puncture.
    Summary · context
    Immediately and at 5 h after the operation, SS-31 (5 mg/kg) or vehicle was administered intraperitoneally.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In animals with cecal ligation and puncture sepsis, SS‑31 treatment decreased serum creatinine versus vehicle.

    In plain wordsIn animals with sepsis, SS‑31 treatment lowered a blood marker of kidney injury (creatinine) compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseSerum creatinine
    Study

    n: not reported in source

    cecal ligation and puncture (CLP) sepsis
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    5 mg/kg · intraperitoneal · immediately and at 5 h after the operationAs given in this study.

    Source sentences

    Summary
    deceased serum alanine aminotransferase, urea nitrogen, and creatinine levels
    2 context sentences
    Summary · context
    Sepsis was induced by cecal ligation and puncture.
    Summary · context
    Immediately and at 5 h after the operation, SS-31 (5 mg/kg) or vehicle was administered intraperitoneally.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In animals with cecal ligation and puncture sepsis, SS‑31 treatment decreased malondialdehyde, a marker of oxidative stress, versus vehicle.

    In plain wordsIn animals with sepsis, SS‑31 treatment lowered a marker of oxidative damage compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMalondialdehyde level
    Study

    n: not reported in source

    cecal ligation and puncture (CLP) sepsis
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Whole body
    Studied dose
    5 mg/kg · intraperitoneal · immediately and at 5 h after the operationAs given in this study.

    Source sentences

    Summary
    decreased levels of malondialdehyde, tumor necrosis factor-alpha, pulmonary myeloperoxidase activity, nuclear factor kappa B p65, inducible nitric oxide synthase, reactive oxygen species, and TUNEL-positive cells
    2 context sentences
    Summary · context
    Sepsis was induced by cecal ligation and puncture.
    Summary · context
    Immediately and at 5 h after the operation, SS-31 (5 mg/kg) or vehicle was administered intraperitoneally.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In animals with cecal ligation and puncture sepsis, SS‑31 treatment decreased tumor necrosis factor-alpha versus vehicle.

    In plain wordsIn animals with sepsis, SS‑31 treatment lowered an inflammation signal (TNF-alpha) compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTumor necrosis factor-alpha level
    Study

    n: not reported in source

    cecal ligation and puncture (CLP) sepsis
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    5 mg/kg · intraperitoneal · immediately and at 5 h after the operationAs given in this study.

    Source sentences

    Summary
    decreased levels of malondialdehyde, tumor necrosis factor-alpha, pulmonary myeloperoxidase activity, nuclear factor kappa B p65, inducible nitric oxide synthase, reactive oxygen species, and TUNEL-positive cells
    2 context sentences
    Summary · context
    Sepsis was induced by cecal ligation and puncture.
    Summary · context
    Immediately and at 5 h after the operation, SS-31 (5 mg/kg) or vehicle was administered intraperitoneally.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In animals with cecal ligation and puncture sepsis, SS‑31 treatment decreased pulmonary myeloperoxidase activity versus vehicle.

    In plain wordsIn animals with sepsis, SS‑31 treatment lowered a marker of immune cell activity in the lungs compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePulmonary myeloperoxidase activity
    Study

    n: not reported in source

    cecal ligation and puncture (CLP) sepsis
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    5 mg/kg · intraperitoneal · immediately and at 5 h after the operationAs given in this study.

    Source sentences

    Summary
    decreased levels of malondialdehyde, tumor necrosis factor-alpha, pulmonary myeloperoxidase activity, nuclear factor kappa B p65, inducible nitric oxide synthase, reactive oxygen species, and TUNEL-positive cells
    2 context sentences
    Summary · context
    Sepsis was induced by cecal ligation and puncture.
    Summary · context
    Immediately and at 5 h after the operation, SS-31 (5 mg/kg) or vehicle was administered intraperitoneally.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In animals with cecal ligation and puncture sepsis, SS‑31 treatment decreased nuclear factor kappa B p65 versus vehicle.

    In plain wordsIn animals with sepsis, SS‑31 treatment lowered an inflammation-controlling protein (NF-kappa B p65) compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNuclear factor kappa B p65
    Study

    n: not reported in source

    cecal ligation and puncture (CLP) sepsis
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    5 mg/kg · intraperitoneal · immediately and at 5 h after the operationAs given in this study.

    Source sentences

    Summary
    decreased levels of malondialdehyde, tumor necrosis factor-alpha, pulmonary myeloperoxidase activity, nuclear factor kappa B p65, inducible nitric oxide synthase, reactive oxygen species, and TUNEL-positive cells
    2 context sentences
    Summary · context
    Sepsis was induced by cecal ligation and puncture.
    Summary · context
    Immediately and at 5 h after the operation, SS-31 (5 mg/kg) or vehicle was administered intraperitoneally.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In animals with cecal ligation and puncture sepsis, SS‑31 treatment decreased inducible nitric oxide synthase versus vehicle.

    In plain wordsIn animals with sepsis, SS‑31 treatment lowered an inflammation-related enzyme (iNOS) compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseInducible nitric oxide synthase
    Study

    n: not reported in source

    cecal ligation and puncture (CLP) sepsis
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    5 mg/kg · intraperitoneal · immediately and at 5 h after the operationAs given in this study.

    Source sentences

    Summary
    decreased levels of malondialdehyde, tumor necrosis factor-alpha, pulmonary myeloperoxidase activity, nuclear factor kappa B p65, inducible nitric oxide synthase, reactive oxygen species, and TUNEL-positive cells
    2 context sentences
    Summary · context
    Sepsis was induced by cecal ligation and puncture.
    Summary · context
    Immediately and at 5 h after the operation, SS-31 (5 mg/kg) or vehicle was administered intraperitoneally.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In animals with cecal ligation and puncture sepsis, SS‑31 treatment decreased reactive oxygen species versus vehicle.

    In plain wordsIn animals with sepsis, SS‑31 treatment lowered reactive oxygen species compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseReactive oxygen species
    Study

    n: not reported in source

    cecal ligation and puncture (CLP) sepsis
    Comparator
    Vehicle
    Outcome group
    Mitochondrial function · Whole body
    Studied dose
    5 mg/kg · intraperitoneal · immediately and at 5 h after the operationAs given in this study.

    Source sentences

    Summary
    decreased levels of malondialdehyde, tumor necrosis factor-alpha, pulmonary myeloperoxidase activity, nuclear factor kappa B p65, inducible nitric oxide synthase, reactive oxygen species, and TUNEL-positive cells
    2 context sentences
    Summary · context
    Sepsis was induced by cecal ligation and puncture.
    Summary · context
    Immediately and at 5 h after the operation, SS-31 (5 mg/kg) or vehicle was administered intraperitoneally.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In animals with cecal ligation and puncture sepsis, SS‑31 treatment decreased TUNEL-positive apoptotic cells versus vehicle.

    In plain wordsIn animals with sepsis, SS‑31 treatment lowered the number of dying cells compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTUNEL-positive (apoptotic) cells
    Study

    n: not reported in source

    cecal ligation and puncture (CLP) sepsis
    Comparator
    Vehicle
    Outcome group
    Cell viability and death · Whole body
    Studied dose
    5 mg/kg · intraperitoneal · immediately and at 5 h after the operationAs given in this study.

    Source sentences

    Summary
    decreased levels of malondialdehyde, tumor necrosis factor-alpha, pulmonary myeloperoxidase activity, nuclear factor kappa B p65, inducible nitric oxide synthase, reactive oxygen species, and TUNEL-positive cells
    2 context sentences
    Summary · context
    Sepsis was induced by cecal ligation and puncture.
    Summary · context
    Immediately and at 5 h after the operation, SS-31 (5 mg/kg) or vehicle was administered intraperitoneally.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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