Novel modulators of hepatosteatosis, inflammation and fibrogenesis.

Lakshman MR, Reyes-Gordillo K, Varatharajalu R, Arellanes-Robledo J, Leckey LC, Garige M, Shah R

Hepatology international26 Mar 2014Cited by 10 (Europe PMC)

PMID26201319DOI10.1007/s12072-014-9526-8PepBankPUB-26201319

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with CCl4-induced hepatotoxicity, Tβ4 prevented CCl4-induced necrosis.
In plain wordsIn rats with liver damage from a toxin, thymosin beta‑4 prevented liver cell death.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseHepatic necrosis
Study
ratn: not reported in source
carbon tetrachloride (CCl4)-induced hepatotoxicity
Comparator
CCl4 without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Tβ4 prevented CCl4-induced (i) necrosis, inflammatory infiltration
1 context sentence(design, population, supporting numbers)
Summary · context
Similarly, because of its anti-inflammatory and anti-fibrotic effects in other organs, we evaluated the protective effects of thymosin β4 (Tβ4) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rat.
Report a problemFND-2620131901
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with CCl4-induced hepatotoxicity, Tβ4 prevented CCl4-induced inflammatory infiltration.
In plain wordsIn rats with liver damage from a toxin, thymosin beta‑4 prevented immune cell build-up in the liver.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseHepatic inflammatory infiltration
Study
ratn: not reported in source
carbon tetrachloride (CCl4)-induced hepatotoxicity
Comparator
CCl4 without Tβ4
Outcome group
Inflammation markers · Liver
Studied dose
Dose not stated
Source sentences
Summary
Tβ4 prevented CCl4-induced (i) necrosis, inflammatory infiltration
1 context sentence(design, population, supporting numbers)
Summary · context
Similarly, because of its anti-inflammatory and anti-fibrotic effects in other organs, we evaluated the protective effects of thymosin β4 (Tβ4) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rat.
Report a problemFND-2620131902
03AnimalAnimal study (in vivo)Mechanism
In rats with CCl4-induced hepatotoxicity, Tβ4 prevented the CCl4-induced up-regulation of α1(2)collagen mRNA.
In plain wordsIn rats with liver damage from a toxin, thymosin beta‑4 prevented a rise in a scarring-related collagen gene.
Peptide
Thymosin beta-4 (human)
Outcome
Decreaseα1(2)collagen mRNA expression
Study
ratn: not reported in source
carbon tetrachloride (CCl4)-induced hepatotoxicity
Comparator
CCl4 without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Tβ4 prevented CCl4-induced (i) necrosis, inflammatory infiltration and up-regulation of α1(2)collagen, alpha-smooth muscle actin (α-SMA), platelet derived growth factor beta (PDGF-β) receptor and fibronectin mRNA expression
1 context sentence(design, population, supporting numbers)
Summary · context
Similarly, because of its anti-inflammatory and anti-fibrotic effects in other organs, we evaluated the protective effects of thymosin β4 (Tβ4) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rat.
Report a problemFND-2620131903
04AnimalAnimal study (in vivo)Mechanism
In rats with CCl4-induced hepatotoxicity, Tβ4 prevented the CCl4-induced up-regulation of alpha-smooth muscle actin (α-SMA) mRNA.
In plain wordsIn rats with liver damage from a toxin, thymosin beta‑4 prevented a rise in a scarring-related gene (α-SMA).
Peptide
Thymosin beta-4 (human)
Outcome
Decreaseα-SMA mRNA expression
Study
ratn: not reported in source
carbon tetrachloride (CCl4)-induced hepatotoxicity
Comparator
CCl4 without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Tβ4 prevented CCl4-induced (i) necrosis, inflammatory infiltration and up-regulation of α1(2)collagen, alpha-smooth muscle actin (α-SMA), platelet derived growth factor beta (PDGF-β) receptor and fibronectin mRNA expression
1 context sentence(design, population, supporting numbers)
Summary · context
Similarly, because of its anti-inflammatory and anti-fibrotic effects in other organs, we evaluated the protective effects of thymosin β4 (Tβ4) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rat.
Report a problemFND-2620131904
05AnimalAnimal study (in vivo)Mechanism
In rats with CCl4-induced hepatotoxicity, Tβ4 prevented the CCl4-induced up-regulation of platelet derived growth factor beta (PDGF-β) receptor mRNA.
In plain wordsIn rats with liver damage from a toxin, thymosin beta‑4 prevented a rise in a scarring-related receptor gene.
Peptide
Thymosin beta-4 (human)
Outcome
DecreasePDGF-β receptor mRNA expression
Study
ratn: not reported in source
carbon tetrachloride (CCl4)-induced hepatotoxicity
Comparator
CCl4 without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Tβ4 prevented CCl4-induced (i) necrosis, inflammatory infiltration and up-regulation of α1(2)collagen, alpha-smooth muscle actin (α-SMA), platelet derived growth factor beta (PDGF-β) receptor and fibronectin mRNA expression
1 context sentence(design, population, supporting numbers)
Summary · context
Similarly, because of its anti-inflammatory and anti-fibrotic effects in other organs, we evaluated the protective effects of thymosin β4 (Tβ4) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rat.
Report a problemFND-2620131905
06AnimalAnimal study (in vivo)Mechanism
In rats with CCl4-induced hepatotoxicity, Tβ4 prevented the CCl4-induced up-regulation of fibronectin mRNA.
In plain wordsIn rats with liver damage from a toxin, thymosin beta‑4 prevented a rise in a scarring-related gene (fibronectin).
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseFibronectin mRNA expression
Study
ratn: not reported in source
carbon tetrachloride (CCl4)-induced hepatotoxicity
Comparator
CCl4 without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Tβ4 prevented CCl4-induced (i) necrosis, inflammatory infiltration and up-regulation of α1(2)collagen, alpha-smooth muscle actin (α-SMA), platelet derived growth factor beta (PDGF-β) receptor and fibronectin mRNA expression
1 context sentence(design, population, supporting numbers)
Summary · context
Similarly, because of its anti-inflammatory and anti-fibrotic effects in other organs, we evaluated the protective effects of thymosin β4 (Tβ4) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rat.
Report a problemFND-2620131906
07AnimalAnimal study (in vivo)Mechanism
In rats with CCl4-induced hepatotoxicity, Tβ4 prevented the CCl4-induced down-regulation of the adipogenic gene PPARγ.
In plain wordsIn rats with liver damage from a toxin, thymosin beta‑4 prevented a fall in the PPARγ gene, which limits liver scarring.
Peptide
Thymosin beta-4 (human)
Outcome
IncreasePPARγ expression
Study
ratn: not reported in source
carbon tetrachloride (CCl4)-induced hepatotoxicity
Comparator
CCl4 without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
down-regulation of adipogenic gene, PPARγ and the up-regulation of epigenetic repressor gene, methyl CpG binding protein 2 (MeCP2) mRNA levels
2 context sentences(design, population, supporting numbers)
Summary · context
Tβ4 prevented CCl4-induced
Summary · context
Similarly, because of its anti-inflammatory and anti-fibrotic effects in other organs, we evaluated the protective effects of thymosin β4 (Tβ4) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rat.
Report a problemFND-2620131907
08AnimalAnimal study (in vivo)Mechanism
In rats with CCl4-induced hepatotoxicity, Tβ4 prevented the CCl4-induced up-regulation of the epigenetic repressor gene MeCP2 mRNA.
In plain wordsIn rats with liver damage from a toxin, thymosin beta‑4 prevented a rise in the MeCP2 gene, which promotes liver scarring.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseMeCP2 mRNA expression
Study
ratn: not reported in source
carbon tetrachloride (CCl4)-induced hepatotoxicity
Comparator
CCl4 without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
down-regulation of adipogenic gene, PPARγ and the up-regulation of epigenetic repressor gene, methyl CpG binding protein 2 (MeCP2) mRNA levels
2 context sentences(design, population, supporting numbers)
Summary · context
Tβ4 prevented CCl4-induced
Summary · context
Similarly, because of its anti-inflammatory and anti-fibrotic effects in other organs, we evaluated the protective effects of thymosin β4 (Tβ4) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rat.
Report a problemFND-2620131908

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

Keywords

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