Three-month treatment with triptorelin, letrozole and ulipristal acetate before hysteroscopic resection of uterine myomas: prospective comparative pilot study.

Bizzarri N, Ghirardi V, Remorgida V, Venturini PL, Ferrero S

European journal of obstetrics, gynecology, and reproductive biology25 Jun 2015Cited by 29 (Europe PMC)

PMID26142912DOI10.1016/j.ejogrb.2015.06.018PepBankPUB-26142912

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanNon-randomized trialOther
In women with myomas, complications, postoperative pain and satisfaction were similar across triptorelin, letrozole, ulipristal acetate and direct-surgery groups.
In plain wordsWomen had similar complications, postoperative pain and satisfaction with triptorelin, letrozole, ulipristal acetate or direct surgery.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changePerioperative complications, pain and satisfaction
Study
n = 61
Comparator
Direct surgery, letrozole, and ulipristal acetate groups
Outcome group
Surgical outcomes · Whole body
Studied dose
3.75 mg every 28 days · 3 monthsAs given in this study (human).
Source sentences
Summary
Intra- and postoperative complications, postoperative pain, and patient satisfaction were similar in the four study groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Single center prospective non-randomized comparative pilot study.
Summary · context
The study included consecutive premenopausal patients undergoing hysteroscopic resection of myomas graded as type 0, type 1 or type 2 according to the FIGO classification with diameter between 20 and 35 mm.
Summary · context
This study enrolled patients who underwent either direct surgery (group S; n=23) or 3-month preoperative treatment with triptorelin (3.75 mg every 28 days; group T; n=20)
Report a problemFND-2614291205
02HumanNon-randomized trialEfficacy outcome
In women with myomas, preoperative triptorelin reduced hysteroscopy time compared with direct surgery.
In plain wordsWomen receiving triptorelin had shorter hysteroscopy times than women undergoing direct surgery.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseHysteroscopy time
Study
n = 43
Comparator
Direct surgery
Outcome group
Surgical outcomes · Reproductive and sexual health
Studied dose
3.75 mg every 28 days · 3 monthsAs given in this study (human).
Source sentences
Summary
The hysteroscopy time was higher in group S than in group T (p<.001) and in group L (p=.001);
3 context sentences(design, population, supporting numbers)
Summary · context
Single center prospective non-randomized comparative pilot study.
Summary · context
The study included consecutive premenopausal patients undergoing hysteroscopic resection of myomas graded as type 0, type 1 or type 2 according to the FIGO classification with diameter between 20 and 35 mm.
Summary · context
This study enrolled patients who underwent either direct surgery (group S; n=23) or 3-month preoperative treatment with triptorelin (3.75 mg every 28 days; group T; n=20)
Report a problemFND-2614291203
03HumanNon-randomized trialEfficacy outcome
In women with myomas, preoperative triptorelin reduced fluid absorption compared with direct surgery.
In plain wordsWomen receiving triptorelin absorbed less fluid during surgery than women undergoing direct surgery.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFluid absorption
Study
n = 43
Comparator
Direct surgery
Outcome group
Surgical outcomes · Reproductive and sexual health
Studied dose
3.75 mg every 28 days · 3 monthsAs given in this study (human).
Source sentences
Summary
Fluid absorption was lower in group T than in group S (p=.002) and in group L than in group S (p=.048);
3 context sentences(design, population, supporting numbers)
Summary · context
Single center prospective non-randomized comparative pilot study.
Summary · context
The study included consecutive premenopausal patients undergoing hysteroscopic resection of myomas graded as type 0, type 1 or type 2 according to the FIGO classification with diameter between 20 and 35 mm.
Summary · context
This study enrolled patients who underwent either direct surgery (group S; n=23) or 3-month preoperative treatment with triptorelin (3.75 mg every 28 days; group T; n=20)
Report a problemFND-2614291204
04HumanNon-randomized trialEfficacy outcome
In women with myomas, surgeons rated operative difficulty more favorably after triptorelin than with direct surgery.
In plain wordsSurgeons rated surgery easier after triptorelin than with direct surgery in women with myomas.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseOperative difficulty evaluation
Study
n = 43
Comparator
Direct surgery
Outcome group
Surgical outcomes · Reproductive and sexual health
Studied dose
3.75 mg every 28 days · 3 monthsAs given in this study (human).
Source sentences
Summary
Surgeon's evaluation of operative difficulty was better in group T than in group S (p<.005).
3 context sentences(design, population, supporting numbers)
Summary · context
Single center prospective non-randomized comparative pilot study.
Summary · context
The study included consecutive premenopausal patients undergoing hysteroscopic resection of myomas graded as type 0, type 1 or type 2 according to the FIGO classification with diameter between 20 and 35 mm.
Summary · context
This study enrolled patients who underwent either direct surgery (group S; n=23) or 3-month preoperative treatment with triptorelin (3.75 mg every 28 days; group T; n=20)
Report a problemFND-2614291206
05HumanNon-randomized trialEfficacy outcome
In premenopausal women with myomas, triptorelin produced a greater percentage volume reduction than ulipristal acetate.
In plain wordsWomen receiving triptorelin had greater myoma shrinkage than those receiving ulipristal acetate.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseMyoma volume reduction
Study
n = 27
Comparator
Ulipristal acetate
Outcome group
Tumor growth · Reproductive and sexual health
Studied dose
3.75 mg every 28 days · 3 monthsAs given in this study (human).
Source sentences
Summary
however, the percentage decrease in myoma volume was lower in group U than in group T (p=.001) and in group L (p=.010).
3 context sentences(design, population, supporting numbers)
Summary · context
Single center prospective non-randomized comparative pilot study.
Summary · context
The study included consecutive premenopausal patients undergoing hysteroscopic resection of myomas graded as type 0, type 1 or type 2 according to the FIGO classification with diameter between 20 and 35 mm.
Summary · context
This study enrolled patients who underwent either direct surgery (group S; n=23) or 3-month preoperative treatment with triptorelin (3.75 mg every 28 days; group T; n=20)
Report a problemFND-2614291202
06HumanNon-randomized trialEfficacy outcome
In premenopausal women with submucosal myomas, triptorelin reduced myoma volume from baseline.
In plain wordsWomen with submucosal myomas had smaller myomas after triptorelin than at baseline.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseMyoma volume
Study
n = 20
Outcome group
Tumor growth · Reproductive and sexual health
Studied dose
3.75 mg every 28 days · 3 monthsAs given in this study (human).
Source sentences
Summary
All medical treatments caused a significant decrease in the volume of myomas (group T, p<.001; group L, p<.001; group U, p=.006)
3 context sentences(design, population, supporting numbers)
Summary · context
Single center prospective non-randomized comparative pilot study.
Summary · context
The study included consecutive premenopausal patients undergoing hysteroscopic resection of myomas graded as type 0, type 1 or type 2 according to the FIGO classification with diameter between 20 and 35 mm.
Summary · context
This study enrolled patients who underwent either direct surgery (group S; n=23) or 3-month preoperative treatment with triptorelin (3.75 mg every 28 days; group T; n=20)
Report a problemFND-2614291201

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

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Three-month treatment with triptorelin, letrozole and ulipristal acetate before hysteroscopic resection of uterine myomas: prospective comparative pilot study.

Summary

Results from this study6

Version history

Subjects

Publication types

MeSH terms

Keywords