Pharmacodynamics and tolerability of repository corticotropin injection in healthy human subjects: A comparison with intravenous methylprednisolone.

Lal R, Bell S, Challenger R, Hammock V, Nyberg M, Decker D, Becker PM, Young D

Journal of clinical pharmacology10 Sept 2015Cited by 16 (Europe PMC)

PMID26120075PMCIDPMC5049675DOI10.1002/jcph.582PepBankPUB-26120075

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanRandomized controlled trialMechanism
In healthy subjects, repository corticotropin increased granulocyte numbers, but the increase was significantly smaller than with IV methylprednisolone.
In plain wordsIn healthy subjects, repository corticotropin increased granulocyte numbers less than IV methylprednisolone.
Peptide
ACTH (corticotropin)
Outcome
DecreaseGranulocyte numbers
Study
n: not reported in source
Comparator
Intravenous methylprednisolone 1 g daily
Outcome group
Immune response · Immune and inflammation
Studied dose
80 U daily · subcutaneous · 5 daysAs given in this study (human).
Source sentences
Summary
IVMP and ACTH analog increased granulocyte numbers and decreased lymphocyte counts; effects on both were significantly less pronounced with ACTH analog.
2 context sentences(design, population, supporting numbers)
Summary · context
Repository corticotropin injection (porcine adrenocorticotropic hormone [ACTH] analog) and intravenous methylprednisolone (IVMP) are used to treat inflammatory conditions such as multiple sclerosis (MS) exacerbations and rheumatoid arthritis.
Summary · context
This multiple-dose, randomized, crossover, open-label study evaluated and compared pharmacodynamic outcomes in subjects who received ACTH analog (80 U subcutaneously) or IVMP (1 g) daily for 5 days.
Report a problemFND-2612007501
02HumanRandomized controlled trialMechanism
In healthy subjects, repository corticotropin decreased lymphocyte counts, but the decrease was significantly smaller than with IV methylprednisolone.
In plain wordsIn healthy subjects, repository corticotropin reduced lymphocyte counts less than IV methylprednisolone.
Peptide
ACTH (corticotropin)
Outcome
IncreaseLymphocyte counts
Study
n: not reported in source
Comparator
Intravenous methylprednisolone 1 g daily
Outcome group
Immune response · Immune and inflammation
Studied dose
80 U daily · subcutaneous · 5 daysAs given in this study (human).
Source sentences
Summary
IVMP and ACTH analog increased granulocyte numbers and decreased lymphocyte counts; effects on both were significantly less pronounced with ACTH analog.
2 context sentences(design, population, supporting numbers)
Summary · context
Repository corticotropin injection (porcine adrenocorticotropic hormone [ACTH] analog) and intravenous methylprednisolone (IVMP) are used to treat inflammatory conditions such as multiple sclerosis (MS) exacerbations and rheumatoid arthritis.
Summary · context
This multiple-dose, randomized, crossover, open-label study evaluated and compared pharmacodynamic outcomes in subjects who received ACTH analog (80 U subcutaneously) or IVMP (1 g) daily for 5 days.
Report a problemFND-2612007502
03HumanRandomized controlled trialPharmacokinetics
In healthy subjects, 80 U repository corticotropin produced cortisol-equivalent exposure corresponding to 30 mg IV methylprednisolone, assuming linearity.
In plain wordsIn healthy subjects, 80 U repository corticotropin produced cortisol-equivalent exposure corresponding to 30 mg IV methylprednisolone, assuming linearity.
Peptide
ACTH (corticotropin)
Outcome
Not applicableCortisol-equivalent exposure
Study
n: not reported in source
Comparator
IV methylprednisolone
Outcome group
Pharmacokinetics · Endocrine and hormones
Studied dose
80 U daily · subcutaneous · 5 daysAs given in this study (human).
Measurements
IVMP-equivalent cortisol exposure of 80 U ACTH analog
30 mg
80 U daily ACTH analog, assuming linearity
Source sentences
Summary
Based on total cortisol-equivalent exposure (assuming linearity), administration of 80 U of ACTH analog equates to 30 mg IVMP.
2 context sentences(design, population, supporting numbers)
Summary · context
Repository corticotropin injection (porcine adrenocorticotropic hormone [ACTH] analog) and intravenous methylprednisolone (IVMP) are used to treat inflammatory conditions such as multiple sclerosis (MS) exacerbations and rheumatoid arthritis.
Summary · context
This multiple-dose, randomized, crossover, open-label study evaluated and compared pharmacodynamic outcomes in subjects who received ACTH analog (80 U subcutaneously) or IVMP (1 g) daily for 5 days.
Report a problemFND-2612007503
04HumanRandomized controlled trialSafety outcome
In healthy subjects, adverse event reporting incidence was similar following repository corticotropin and IV methylprednisolone.
In plain wordsIn healthy subjects, adverse event reporting was similar after repository corticotropin and IV methylprednisolone.
Peptide
ACTH (corticotropin)
Outcome
No significant changeAdverse event reporting incidence
Study
n: not reported in source
Comparator
Intravenous methylprednisolone 1 g daily
Outcome group
Adverse events · Whole body
Studied dose
80 U daily · subcutaneous · 5 daysAs given in this study (human).
Source sentences
Summary
Adverse events were mild in severity; subject incidence for adverse-event reporting was similar following both regimens.
2 context sentences(design, population, supporting numbers)
Summary · context
Repository corticotropin injection (porcine adrenocorticotropic hormone [ACTH] analog) and intravenous methylprednisolone (IVMP) are used to treat inflammatory conditions such as multiple sclerosis (MS) exacerbations and rheumatoid arthritis.
Summary · context
This multiple-dose, randomized, crossover, open-label study evaluated and compared pharmacodynamic outcomes in subjects who received ACTH analog (80 U subcutaneously) or IVMP (1 g) daily for 5 days.
Report a problemFND-2612007505
05HumanNon-randomized trialSafety outcome
In healthy subjects, adverse events after repository corticotropin were mild.
In plain wordsIn healthy subjects, adverse events after repository corticotropin were mild.
Peptide
ACTH (corticotropin)
Outcome
Not applicableAdverse event severity
Study
n: not reported in source
Outcome group
Adverse events · Whole body
Studied dose
80 U daily · subcutaneous · 5 daysAs given in this study (human).
Source sentences
Summary
Adverse events were mild in severity; subject incidence for adverse-event reporting was similar following both regimens.
2 context sentences(design, population, supporting numbers)
Summary · context
Repository corticotropin injection (porcine adrenocorticotropic hormone [ACTH] analog) and intravenous methylprednisolone (IVMP) are used to treat inflammatory conditions such as multiple sclerosis (MS) exacerbations and rheumatoid arthritis.
Summary · context
This multiple-dose, randomized, crossover, open-label study evaluated and compared pharmacodynamic outcomes in subjects who received ACTH analog (80 U subcutaneously) or IVMP (1 g) daily for 5 days.
Report a problemFND-2612007504

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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