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Study · Measured the body's own peptide · 2015

4 results

Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production.

Paharkova V, Alvarez G, Nakamura H, Cohen P, Lee KW

Molecular and cellular endocrinology23 Jun 2015Cited by 39 (Europe PMC)

PMID26116236 (opens in a new tab)DOI10.1016/j.mce.2015.06.015 (opens in a new tab)PepBankPUB-26116236
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In Rho-0 cells, production of the body's own rat humanin was decreased, which indicates a mitochondrial genome origin.

    In plain wordsIn rat-derived cells, the body's own humanin was made at lower levels in cells without mitochondrial DNA.

    Peptide
    Humanin
    Outcome
    DecreaseRat humanin production in Rho-0 cells (no mitochondrial DNA)
    Study

    ratn: not reported in source

    Rho-0 cells
    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    We found that the rat HN (Rattin; rHN) homologue is derived from the mitochondrial genome as evidenced by decreased production in Rho-0 cells, and that peptide translation occurs in the mitochondria as it is unaffected by cycloheximide.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In rat-derived cells, translation of the body's own rat humanin was unaffected by cycloheximide, which indicates mitochondrial translation.

    In plain wordsIn rat-derived cells, the body's own humanin was still made when cycloheximide was added.

    Peptide
    Humanin
    Outcome
    No significant changeRat humanin translation with cycloheximide
    Study

    ratn: not reported in source

    rat-derived cellular system
    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    We found that the rat HN (Rattin; rHN) homologue is derived from the mitochondrial genome as evidenced by decreased production in Rho-0 cells, and that peptide translation occurs in the mitochondria as it is unaffected by cycloheximide.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    In rat-derived cells, the body's own rat humanin localized to the mitochondria in subfractionation and immunohistochemical studies.

    In plain wordsIn rat-derived cells, the body's own humanin was found in the mitochondria.

    Peptide
    Humanin
    Outcome
    Not applicableSubcellular location of rat humanin
    Study

    ratn: not reported in source

    rat-derived cellular system
    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    Rat HN localizes to the mitochondria in cellular subfractionation and immunohistochemical studies.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 04LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    In isolated mitochondria from rat INS-1 beta cells, a humanin analogue reduced hydrogen peroxide production by 55%.

    In plain wordsIn lab tests on rat cell mitochondria, a humanin analogue cut hydrogen peroxide production by 55%.

    Peptide
    Humanin
    Outcome
    DecreaseHydrogen peroxide production in isolated mitochondria
    Study

    ratn: not reported in source

    isolated mitochondria from rat INS-1 beta cells
    Outcome group
    Mitochondrial function · Metabolic and weight

    Measurements

    Hydrogen peroxide production reduction
    55%
    isolated INS-1 mitochondria

    Source sentences

    Summary
    Addition of a HN analogue to isolated mitochondria from rat INS-1 beta cells reduced hydrogen peroxide production by 55%.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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