Stability of peptide drugs in the colon.

Wang J, Yadav V, Smart AL, Tajiri S, Basit AW

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences23 Jun 2015Cited by 43 (Europe PMC)

PMID26111980DOI10.1016/j.ejps.2015.06.018PepBankPUB-26111980

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

01LabNot a test of Goserelin aloneIn vitro (cells)Activity measurement
In lab tests, goserelin degraded more slowly than the rapidly metabolized larger peptides in a colonic model.
In plain wordsIn lab tests, goserelin degraded more slowly than larger peptides in a colonic model.
Peptide
Goserelin
Outcome
DecreaseColonic degradation
Study
n: not reported in source
Mixed human faecal bacteria model
Comparator
Larger peptides: insulin, calcitonin, somatostatin, glucagon and secretin
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
In contrast, a number of the smaller peptides - Arg-vasopressin, desmopressin, oxytocin, gonadorelin, goserelin, buserelin, leuprolide, nafarelin and deslorelin - degraded more slowly, while octreotide, histrelin and ciclosporin were seen to be more stable as compared to the other small peptides und…
2 context sentences(design, population, supporting numbers)
Summary · context
Of these, the larger peptides - insulin, calcitonin, somatostatin, glucagon and secretin - were metabolized rapidly, with complete degradation observed within 5 min.
Summary · context
This study was the first to investigate the colonic stability of 17 peptide molecules (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, Arg-vasopressin, octreotide, ciclosporin, leuprolide, nafarelin, buserelin, histrelin, [D-Ser(4)]-gonadorelin, deslorelin, and goserel…
In this study, Goserelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Goserelin.
Report a problemFND-2611198001
02LabNot a test of Nafarelin aloneIn vitro (cells)Activity measurement
In lab tests, nafarelin degraded more slowly than the rapidly metabolized larger peptides in a colonic model.
In plain wordsIn lab tests, nafarelin degraded more slowly than larger peptides in a colonic model.
Peptide
Nafarelin
Outcome
DecreaseColonic degradation
Study
n: not reported in source
Mixed human faecal bacteria model
Comparator
Larger peptides: insulin, calcitonin, somatostatin, glucagon and secretin
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
In contrast, a number of the smaller peptides - Arg-vasopressin, desmopressin, oxytocin, gonadorelin, goserelin, buserelin, leuprolide, nafarelin and deslorelin - degraded more slowly, while octreotide, histrelin and ciclosporin were seen to be more stable as compared to the other small peptides und…
2 context sentences(design, population, supporting numbers)
Summary · context
Of these, the larger peptides - insulin, calcitonin, somatostatin, glucagon and secretin - were metabolized rapidly, with complete degradation observed within 5 min.
Summary · context
This study was the first to investigate the colonic stability of 17 peptide molecules (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, Arg-vasopressin, octreotide, ciclosporin, leuprolide, nafarelin, buserelin, histrelin, [D-Ser(4)]-gonadorelin, deslorelin, and goserel…
In this study, Nafarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Nafarelin.
Report a problemFND-2611198002
03LabNot a test of Oxytocin aloneIn vitro (cells)Activity measurement
In lab tests, oxytocin degraded more slowly than the rapidly metabolized larger peptides in a colonic model.
In plain wordsIn lab tests, oxytocin degraded more slowly than larger peptides in a colonic model.
Peptide
Oxytocin
Outcome
DecreaseColonic degradation
Study
n: not reported in source
Mixed human faecal bacteria model
Comparator
Larger peptides: insulin, calcitonin, somatostatin, glucagon and secretin
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
In contrast, a number of the smaller peptides - Arg-vasopressin, desmopressin, oxytocin, gonadorelin, goserelin, buserelin, leuprolide, nafarelin and deslorelin - degraded more slowly, while octreotide, histrelin and ciclosporin were seen to be more stable as compared to the other small peptides und…
2 context sentences(design, population, supporting numbers)
Summary · context
Of these, the larger peptides - insulin, calcitonin, somatostatin, glucagon and secretin - were metabolized rapidly, with complete degradation observed within 5 min.
Summary · context
This study was the first to investigate the colonic stability of 17 peptide molecules (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, Arg-vasopressin, octreotide, ciclosporin, leuprolide, nafarelin, buserelin, histrelin, [D-Ser(4)]-gonadorelin, deslorelin, and goserel…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2611198003
04LabNot a test of Histrelin aloneIn vitro (cells)Activity measurement
In lab tests, histrelin was more stable than other small peptides under the same colonic conditions.
In plain wordsIn lab tests, histrelin was more stable than other small peptides under the same colonic conditions.
Peptide
Histrelin
Outcome
IncreaseColonic stability
Study
n: not reported in source
Mixed human faecal bacteria model
Comparator
Other small peptides
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
In contrast, a number of the smaller peptides - Arg-vasopressin, desmopressin, oxytocin, gonadorelin, goserelin, buserelin, leuprolide, nafarelin and deslorelin - degraded more slowly, while octreotide, histrelin and ciclosporin were seen to be more stable as compared to the other small peptides und…
1 context sentence(design, population, supporting numbers)
Summary · context
This study was the first to investigate the colonic stability of 17 peptide molecules (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, Arg-vasopressin, octreotide, ciclosporin, leuprolide, nafarelin, buserelin, histrelin, [D-Ser(4)]-gonadorelin, deslorelin, and goserel…
In this study, Histrelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Histrelin.
Report a problemFND-2611198004
05LabNot a test of Goserelin aloneIn vitro (cell-free)Activity measurement
In lab tests, goserelin was stable without human faecal bacteria.
In plain wordsIn lab tests, goserelin was stable without human faecal bacteria.
Peptide
Goserelin
Outcome
Direction not reportedStability without bacteria
Study
n: not reported in source
Colonic model without human faecal bacteria
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
In the absence of human faecal bacteria, all peptides were stable.
In this study, Goserelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Goserelin.
Report a problemFND-2611198005
06LabNot a test of Histrelin aloneIn vitro (cell-free)Activity measurement
In lab tests, histrelin was stable without human faecal bacteria.
In plain wordsIn lab tests, histrelin was stable without human faecal bacteria.
Peptide
Histrelin
Outcome
Direction not reportedStability without bacteria
Study
n: not reported in source
Colonic model without human faecal bacteria
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
In the absence of human faecal bacteria, all peptides were stable.
In this study, Histrelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Histrelin.
Report a problemFND-2611198006
07LabNot a test of Nafarelin aloneIn vitro (cell-free)Activity measurement
In lab tests, nafarelin was stable without human faecal bacteria.
In plain wordsIn lab tests, nafarelin was stable without human faecal bacteria.
Peptide
Nafarelin
Outcome
Direction not reportedStability without bacteria
Study
n: not reported in source
Colonic model without human faecal bacteria
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
In the absence of human faecal bacteria, all peptides were stable.
In this study, Nafarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Nafarelin.
Report a problemFND-2611198007
08LabNot a test of Oxytocin aloneIn vitro (cell-free)Activity measurement
In lab tests, oxytocin was stable without human faecal bacteria.
In plain wordsIn lab tests, oxytocin was stable without human faecal bacteria.
Peptide
Oxytocin
Outcome
Direction not reportedStability without bacteria
Study
n: not reported in source
Colonic model without human faecal bacteria
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
In the absence of human faecal bacteria, all peptides were stable.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2611198008

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 5Current
28 Oct 2026, 02:03 UTC
Study results updated
Versions 2 to 4
27 Oct 2026, 16:36 UTC
The same notice was added 3 times, first on 27 Oct 2026, 16:35 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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