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Study · Animal study (in vivo) · mouse · 2015

5 results

Thymosin β4 significantly reduces the signs of dryness in a murine controlled adverse environment model of experimental dry eye.

Sosne G, Kim C, Kleinman HK

Expert opinion on biological therapy22 Jun 2015Cited by 13 (Europe PMC)

PMID26096547 (opens in a new tab)DOI10.1517/14712598.2015.1019858 (opens in a new tab)PepBankPUB-26096547
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with severe dry eye, Tβ4 significantly reduced the signs of dry eye relative to controls.

    In plain wordsIn mice with dry eye, Tβ4 reduced signs of dry eye compared with controls.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseSigns of dry eye (fluorescein staining) versus controls
    Study

    mousen = 5

    scopolamine plus controlled adverse environment chamber dry eye
    Comparator
    Controls
    Outcome group
    Wound healing · Eye
    Studied dose
    six doses tested twice per day · 12 daysAs given in this study (mouse).

    Source sentences

    Summary
    Tβ4 significantly reduced the signs of dry eye relative to controls.
    2 context sentences
    Summary · context
    The study was performed using a controlled adverse environment chamber (CAE) in combination with scopolamine to induce moderate to severe dry eye in mice.
    Summary · context
    The study included five mice per group and tested six different doses of Tβ4 twice per day for 12 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with severe dry eye, the Tβ4 treatment effect was more pronounced than with the positive control doxycycline.

    In plain wordsIn mice with dry eye, Tβ4 worked better than doxycycline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseSigns of dry eye versus doxycycline
    Study

    mousen = 5

    scopolamine plus controlled adverse environment chamber dry eye
    Comparator
    Doxycycline
    Outcome group
    Wound healing · Eye
    Studied dose
    six doses tested twice per day · 12 daysAs given in this study (mouse).

    Source sentences

    Summary
    The treatment effect was more pronounced than the positive controls, doxycycline and Restasis (cyclosporine 0.05%).
    2 context sentences
    Summary · context
    The study was performed using a controlled adverse environment chamber (CAE) in combination with scopolamine to induce moderate to severe dry eye in mice.
    Summary · context
    The study included five mice per group and tested six different doses of Tβ4 twice per day for 12 days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with severe dry eye, the Tβ4 treatment effect was more pronounced than with the positive control Restasis (cyclosporine 0.05%).

    In plain wordsIn mice with dry eye, Tβ4 worked better than Restasis.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseSigns of dry eye versus Restasis
    Study

    mousen = 5

    scopolamine plus controlled adverse environment chamber dry eye
    Comparator
    Restasis (cyclosporine 0.05%)
    Outcome group
    Wound healing · Eye
    Studied dose
    six doses tested twice per day · 12 daysAs given in this study (mouse).

    Source sentences

    Summary
    The treatment effect was more pronounced than the positive controls, doxycycline and Restasis (cyclosporine 0.05%).
    2 context sentences
    Summary · context
    The study was performed using a controlled adverse environment chamber (CAE) in combination with scopolamine to induce moderate to severe dry eye in mice.
    Summary · context
    The study included five mice per group and tested six different doses of Tβ4 twice per day for 12 days.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with severe dry eye, Tβ4 doses of 0.1 and 0.5% were the active doses for healing.

    In plain wordsIn mice with dry eye, Tβ4 at 0.1% and 0.5% was the active dose.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseActive doses of Tβ4
    Study

    mousen = 5

    scopolamine plus controlled adverse environment chamber dry eye
    Outcome group
    Wound healing · Eye
    Studied dose
    0.1% and 0.5% · 12 daysAs given in this study (mouse).

    Measurements

    Active dose
    0.1 to 0.5%
    Tβ4

    Source sentences

    Summary
    Active doses of 0.1 and 0.5% were determined
    2 context sentences
    Summary · context
    The study was performed using a controlled adverse environment chamber (CAE) in combination with scopolamine to induce moderate to severe dry eye in mice.
    Summary · context
    The study included five mice per group and tested six different doses of Tβ4 twice per day for 12 days.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with severe dry eye, dosing Tβ4 two times per day was the most effective frequency for healing.

    In plain wordsIn mice with dry eye, using Tβ4 two times per day healed best.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseOptimal dosing frequency
    Study

    mousen = 5

    scopolamine plus controlled adverse environment chamber dry eye
    Comparator
    Other dosing frequencies
    Outcome group
    Wound healing · Eye
    Studied dose
    0.1% two to four times per day · 12 daysAs given in this study (mouse).

    Source sentences

    Summary
    it was found that the frequency of dosing at 2 times per day was the most effective for healing.
    3 context sentences
    Summary · context
    Tβ4 at 0.1% was also administered 2 - 4 times per day for 12 days.
    Summary · context
    The study was performed using a controlled adverse environment chamber (CAE) in combination with scopolamine to induce moderate to severe dry eye in mice.
    Summary · context
    The study included five mice per group and tested six different doses of Tβ4 twice per day for 12 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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