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Study · Ex vivo tissue · rabbit and rat · 2015

7 results

Effect of Exogenous Extracellular Nicotinamide Adenine Dinucleotide (NAD⁺) on Bioelectric Activity of the Pacemaker and Conduction System of the Heart.

Pustovit KB, Kuz'min VS, Sukhova GS

Bulletin of experimental biology and medicine19 Jun 2015Cited by 5 (Europe PMC)

PMID26085350 (opens in a new tab)DOI10.1007/s10517-015-2919-4 (opens in a new tab)PepBankPUB-26085350
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In rat sinoatrial node, NAD+ reduced spontaneous action potential rate.

    In plain wordsIn lab tests, NAD+ reduced spontaneous action potential rate in rat sinoatrial node.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseSpontaneous action potential rate
    Study

    ratn: not reported in source

    sinoatrial node
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10 μMAs given in this study (rat).

    Source sentences

    Summary
    In rat sinoatrial node, NAD(+) (10 μM) reduced the rate of spontaneous action potentials, duration of action potentials, and the velocity of slow diastolic depolarization, but the rate of action potential front propagation increases.
  2. 02LabEx vivo tissueActivity measurement

    In rat sinoatrial node, NAD+ reduced action potential duration.

    In plain wordsIn lab tests, NAD+ shortened action potentials in rat sinoatrial node.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseSinoatrial action potential duration
    Study

    ratn: not reported in source

    sinoatrial node
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10 μMAs given in this study (rat).

    Source sentences

    Summary
    In rat sinoatrial node, NAD(+) (10 μM) reduced the rate of spontaneous action potentials, duration of action potentials, and the velocity of slow diastolic depolarization, but the rate of action potential front propagation increases.
  3. 03LabEx vivo tissueActivity measurement

    In rat sinoatrial node, NAD+ reduced slow diastolic depolarization velocity.

    In plain wordsIn lab tests, NAD+ slowed diastolic depolarization in rat sinoatrial node.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseSinoatrial slow diastolic depolarization velocity
    Study

    ratn: not reported in source

    sinoatrial node
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10 μMAs given in this study (rat).

    Source sentences

    Summary
    In rat sinoatrial node, NAD(+) (10 μM) reduced the rate of spontaneous action potentials, duration of action potentials, and the velocity of slow diastolic depolarization, but the rate of action potential front propagation increases.
  4. 04LabEx vivo tissueActivity measurement

    In rat sinoatrial node, NAD+ increased action potential front propagation rate.

    In plain wordsIn lab tests, NAD+ increased action potential propagation rate in rat sinoatrial node.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseAction potential front propagation rate
    Study

    ratn: not reported in source

    sinoatrial node
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10 μMAs given in this study (rat).

    Source sentences

    Summary
    In rat sinoatrial node, NAD(+) (10 μM) reduced the rate of spontaneous action potentials, duration of action potentials, and the velocity of slow diastolic depolarization, but the rate of action potential front propagation increases.
  5. 05LabEx vivo tissueActivity measurement

    In rabbit Purkinje fibers, NAD+ reduced action potential duration.

    In plain wordsIn lab tests, NAD+ shortened action potentials in rabbit Purkinje fibers.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreasePurkinje action potential duration
    Study

    rabbitn: not reported in source

    Purkinje fibers
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10 μMAs given in this study (rabbit).

    Source sentences

    Summary
    In passed rabbit Purkinje fibers, NAD(+) (10 μM) reduced the duration of action potentials.
  6. 06LabEx vivo tissueActivity measurement

    In spontaneously active Purkinje fibers, NAD+ reduced firing rate.

    In plain wordsIn lab tests, NAD+ reduced firing rate in spontaneously active Purkinje fibers.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreasePurkinje firing rate
    Study

    rabbitn: not reported in source

    spontaneously active Purkinje fibers
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Under conditions of spontaneous activity of Purkinje fibers, NAD(+) reduced the fi ring rate and the rate of slow diastolic depolarization.
    1 context sentence
    Summary · context
    In passed rabbit Purkinje fibers, NAD(+) (10 μM) reduced the duration of action potentials.
  7. 07LabEx vivo tissueActivity measurement

    In spontaneously active Purkinje fibers, NAD+ reduced slow diastolic depolarization rate.

    In plain wordsIn lab tests, NAD+ slowed diastolic depolarization in spontaneously active Purkinje fibers.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreasePurkinje slow diastolic depolarization rate
    Study

    rabbitn: not reported in source

    spontaneously active Purkinje fibers
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Under conditions of spontaneous activity of Purkinje fibers, NAD(+) reduced the fi ring rate and the rate of slow diastolic depolarization.
    1 context sentence
    Summary · context
    In passed rabbit Purkinje fibers, NAD(+) (10 μM) reduced the duration of action potentials.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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