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Study · In vitro (cells) · 2015

5 results

Inhibition of SDF-1/CXCR4-induced epithelial-mesenchymal transition by kisspeptin-10.

Gründker C, Bauerschmitz G, Knapp J, Schmidt E, Olbrich T, Emons G

Breast cancer research and treatment11 Jun 2015Cited by 19 (Europe PMC)

PMID26062751 (opens in a new tab)DOI10.1007/s10549-015-3463-7 (opens in a new tab)PepBankPUB-26062751
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In MCF-7 and T-47-D breast cancer cells, kisspeptin‑10 treatment significantly reduced the increase in cell invasion that SDF-1 had induced.

    In plain wordsIn breast cancer cells, kisspeptin‑10 reduced the extra invasion that SDF-1 had caused.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseSDF-1-induced breast cancer cell invasion
    Study

    n: not reported in source

    MCF-7 and T-47-D breast cancer cells
    Outcome group
    Cancer cell invasion and metastasis · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The SDF-1-induced increase of cell invasion was significantly reduced after treatment with KP-10.
    1 context sentence
    Summary · context
    Invasion was quantified by assessment of MCF-7 and T-47-D breast cancer cell migration rate through an artificial basement membrane in a modified Boyden chamber during co-culture with MG63 cells or after treatment with SDF-1α, SDF-1β or the combination of both isoforms.
  2. 02LabIn vitro (cells)Efficacy outcome

    In breast cancer cells, kisspeptin‑10 treatment inhibited the induction of EMT by SDF-1.

    In plain wordsIn breast cancer cells, kisspeptin‑10 blocked the change to a more invasive cell type that SDF-1 caused.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseSDF-1-induced epithelial-mesenchymal transition
    Study

    n: not reported in source

    MCF-7 and T-47-D breast cancer cells
    Outcome group
    Cancer cell invasion and metastasis · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The SDF-1-induced increase of cell invasion was significantly reduced after treatment with KP-10. In addition, induction of EMT was inhibited.
    1 context sentence
    Summary · context
    Invasion was quantified by assessment of MCF-7 and T-47-D breast cancer cell migration rate through an artificial basement membrane in a modified Boyden chamber during co-culture with MG63 cells or after treatment with SDF-1α, SDF-1β or the combination of both isoforms.
  3. 03LabIn vitro (cells)Mechanism

    In breast cancer cells, kisspeptin‑10 reduced protein expression of CXCR4, the binding site of SDF-1.

    In plain wordsIn breast cancer cells, kisspeptin‑10 lowered the amount of CXCR4, the receptor that SDF-1 binds.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseCXCR4 protein expression
    Study

    n: not reported in source

    MCF-7 and T-47-D breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, protein expression of the binding site of SDF-1, CXC-motive-chemokine receptor 4 (CXCR-4), was reduced by KP-10.
    1 context sentence
    Summary · context
    Invasion was quantified by assessment of MCF-7 and T-47-D breast cancer cell migration rate through an artificial basement membrane in a modified Boyden chamber during co-culture with MG63 cells or after treatment with SDF-1α, SDF-1β or the combination of both isoforms.
  4. 04LabIn vitro (cells)Efficacy outcome

    In mesenchymal transformed MCF-7-EMT breast cancer cells, kisspeptin‑10 treatment significantly reduced cell invasion.

    In plain wordsIn transformed breast cancer cells, kisspeptin‑10 lowered cell invasion.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseCell invasion in MCF-7-EMT cells
    Study

    n: not reported in source

    mesenchymal transformed MCF-7 breast cancer cells (MCF-7-EMT)
    Outcome group
    Cancer cell invasion and metastasis · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment of MCF-7-EMT cells with KP-10 resulted in a significant drop of cell invasion and CXCR-4 protein expression.
    1 context sentence
    Summary · context
    Invasion was quantified by assessment of MCF-7 and T-47-D breast cancer cell migration rate through an artificial basement membrane in a modified Boyden chamber during co-culture with MG63 cells or after treatment with SDF-1α, SDF-1β or the combination of both isoforms.
  5. 05LabIn vitro (cells)Mechanism

    In MCF-7-EMT breast cancer cells, kisspeptin‑10 treatment significantly reduced CXCR-4 protein expression.

    In plain wordsIn transformed breast cancer cells, kisspeptin‑10 lowered the amount of the CXCR-4 receptor.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseCXCR4 protein expression in MCF-7-EMT cells
    Study

    n: not reported in source

    mesenchymal transformed MCF-7 breast cancer cells (MCF-7-EMT)
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment of MCF-7-EMT cells with KP-10 resulted in a significant drop of cell invasion and CXCR-4 protein expression.
    1 context sentence
    Summary · context
    Invasion was quantified by assessment of MCF-7 and T-47-D breast cancer cell migration rate through an artificial basement membrane in a modified Boyden chamber during co-culture with MG63 cells or after treatment with SDF-1α, SDF-1β or the combination of both isoforms.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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