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Study · Not a test of the peptide alone · 2015

8 results

Central effects of humanin on hepatic triglyceride secretion.

Gong Z, Su K, Cui L, Tas E, Zhang T, Dong HH, Yakar S, Muzumdar RH

American journal of physiology. Endocrinology and metabolism9 Jun 2015Cited by 31 (Europe PMC)

PMID26058861 (opens in a new tab)PMCIDPMC4525112 (opens in a new tab)DOI10.1152/ajpendo.00043.2015 (opens in a new tab)PepBankPUB-26058861
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In high-fat diet-fed mice, intraperitoneal HNG, a humanin analog, decreased body weight gain.

    In plain wordsIn mice on a high-fat diet, the humanin analog HNG reduced body weight gain.

    Peptide
    Humanin
    Outcome
    DecreaseBody weight gain in high-fat diet-fed mice
    Study

    mousen: not reported in source

    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    intraperitoneal treatment with one of HN analogs, HNG, decreases body weight gain, visceral fat, and hepatic triglyceride (TG) accumulation in high-fat diet-fed mice.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In high-fat diet-fed mice, intraperitoneal HNG, a humanin analog, decreased visceral fat.

    In plain wordsIn mice on a high-fat diet, the humanin analog HNG reduced belly fat.

    Peptide
    Humanin
    Outcome
    DecreaseVisceral fat in high-fat diet-fed mice
    Study

    mousen: not reported in source

    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    intraperitoneal treatment with one of HN analogs, HNG, decreases body weight gain, visceral fat, and hepatic triglyceride (TG) accumulation in high-fat diet-fed mice.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In high-fat diet-fed mice, intraperitoneal HNG, a humanin analog, decreased hepatic triglyceride accumulation.

    In plain wordsIn mice on a high-fat diet, the humanin analog HNG reduced fat build-up in the liver.

    Peptide
    Humanin
    Outcome
    DecreaseHepatic triglyceride accumulation in high-fat diet-fed mice
    Study

    mousen: not reported in source

    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    intraperitoneal treatment with one of HN analogs, HNG, decreases body weight gain, visceral fat, and hepatic triglyceride (TG) accumulation in high-fat diet-fed mice.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In high-fat diet-fed mice treated with HNG, hepatic MTTP activity increased.

    In plain wordsIn mice on a high-fat diet, the humanin analog HNG increased the activity of a liver protein that moves fat out of the liver.

    Peptide
    Humanin
    Outcome
    IncreaseHepatic microsomal triglyceride transfer protein (MTTP) activity
    Study

    mousen: not reported in source

    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    The decrease in hepatic TG accumulation is due to increased activity of hepatic microsomal triglyceride transfer protein (MTTP) and increased hepatic TG secretion.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  5. 05AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In high-fat diet-fed mice treated with HNG, hepatic triglyceride secretion increased.

    In plain wordsIn mice on a high-fat diet, the humanin analog HNG increased the release of fat from the liver.

    Peptide
    Humanin
    Outcome
    IncreaseHepatic triglyceride secretion in high-fat diet-fed mice
    Study

    mousen: not reported in source

    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    The decrease in hepatic TG accumulation is due to increased activity of hepatic microsomal triglyceride transfer protein (MTTP) and increased hepatic TG secretion.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  6. 06AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In mice, acute intravenous infusion of HNG increased triglyceride secretion from the liver.

    In plain wordsIn mice, a short intravenous dose of the humanin analog HNG increased the release of fat from the liver.

    Peptide
    Humanin
    Outcome
    IncreaseTriglyceride secretion after intravenous HNG
    Study

    mousen: not reported in source

    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    Both intravenous (iv) and intracerebroventricular (icv) infusion of HNG acutely increase TG secretion from the liver

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  7. 07AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In mice, acute intracerebroventricular infusion of HNG increased triglyceride secretion from the liver.

    In plain wordsIn mice, a short dose of the humanin analog HNG into the brain increased the release of fat from the liver.

    Peptide
    Humanin
    Outcome
    IncreaseTriglyceride secretion after intracerebroventricular HNG
    Study

    mousen: not reported in source

    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    Both intravenous (iv) and intracerebroventricular (icv) infusion of HNG acutely increase TG secretion from the liver.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  8. 08AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In mice, vagotomy blocked the effect of both intravenous and intracerebroventricular HNG on hepatic triglyceride secretion.

    In plain wordsIn mice, cutting the vagus nerve blocked the effect of the humanin analog HNG on fat release from the liver.

    Peptide
    Humanin
    Outcome
    No significant changeBlock of the HNG effect on triglyceride secretion by vagotomy
    Study

    mousen: not reported in source

    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    Vagotomy blocks the effect on both iv and icv HNG on TG secretion, suggesting that the effects of HNG on hepatic TG flux are centrally mediated.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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