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Study · Not a test of the peptide alone · 2015

5 results

Thymosin Beta-4 Recombinant Adeno-associated Virus Enhances Human Nucleus Pulposus Cell Proliferation and Reduces Cell Apoptosis and Senescence.

Wang YY, Zhu QS, Wang YW, Yin RF

Chinese medical journal1 Jun 2015Cited by 11 (Europe PMC)

PMID26021512 (opens in a new tab)PMCIDPMC4733779 (opens in a new tab)DOI10.4103/0366-6999.157686 (opens in a new tab)PepBankPUB-26021512
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In human nucleus pulposus cells, TB-4 recombinant AAV transfection gave normal TB-4 expression and exocytosis.

    In plain wordsIn cells, AAV delivery of TB-4 produced normal TB-4 expression and release.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTB-4 expression after transfection
    Study

    humann: not reported in source

    human nucleus pulposus cells
    Comparator
    Untransfected control cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    NP cells with TB-4 transfection has normal TB-4 expression and exocytosis.
    2 context sentences
    Summary · context
    TB-4 recombinant adeno-associated virus (AAV) was constructed and induced to human NP cells.
    Summary · context
    Cell of same group were cultured without gene modification as controlled group.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In human nucleus pulposus cells, TB-4 transfection gave significantly higher cell activity than control in each generation.

    In plain wordsIn cells, TB-4 delivery gave higher cell activity than control cells in each generation.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCell activity across generations
    Study

    humann: not reported in source

    human nucleus pulposus cells
    Comparator
    Untransfected control cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    NP cells with TB-4 transfection performed significantly higher cell activity than that at the control group in each generation.
    2 context sentences
    Summary · context
    TB-4 recombinant adeno-associated virus (AAV) was constructed and induced to human NP cells.
    Summary · context
    Cell of same group were cultured without gene modification as controlled group.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In human nucleus pulposus cells, TB-4 recombinant AAV transfection slowed cell aging versus control.

    In plain wordsIn cells, TB-4 delivery slowed cell aging compared with control cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCell aging
    Study

    humann: not reported in source

    human nucleus pulposus cells
    Comparator
    Untransfected control cells
    Outcome group
    Aging markers · Musculoskeletal

    Source sentences

    Summary
    TB-4 recombinant AAV-transfected human NP cells also show slower cell aging, lower cell apoptosis and higher cell proliferation than control group.
    2 context sentences
    Summary · context
    TB-4 recombinant adeno-associated virus (AAV) was constructed and induced to human NP cells.
    Summary · context
    Cell of same group were cultured without gene modification as controlled group.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In human nucleus pulposus cells, TB-4 recombinant AAV transfection lowered cell apoptosis versus control.

    In plain wordsIn cells, TB-4 delivery lowered cell death compared with control cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCell apoptosis
    Study

    humann: not reported in source

    human nucleus pulposus cells
    Comparator
    Untransfected control cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    TB-4 recombinant AAV-transfected human NP cells also show slower cell aging, lower cell apoptosis and higher cell proliferation than control group.
    2 context sentences
    Summary · context
    TB-4 recombinant adeno-associated virus (AAV) was constructed and induced to human NP cells.
    Summary · context
    Cell of same group were cultured without gene modification as controlled group.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  5. 05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In human nucleus pulposus cells, TB-4 recombinant AAV transfection raised cell proliferation versus control.

    In plain wordsIn cells, TB-4 delivery increased cell growth compared with control cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCell proliferation
    Study

    humann: not reported in source

    human nucleus pulposus cells
    Comparator
    Untransfected control cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    TB-4 recombinant AAV-transfected human NP cells also show slower cell aging, lower cell apoptosis and higher cell proliferation than control group.
    2 context sentences
    Summary · context
    TB-4 recombinant adeno-associated virus (AAV) was constructed and induced to human NP cells.
    Summary · context
    Cell of same group were cultured without gene modification as controlled group.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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