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Study · Animal study (in vivo) · rat · 2015

12 results

Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro.

Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W

Drug design, development and therapy30 Apr 2015Cited by 94 (Europe PMC)

PMID25995620 (opens in a new tab)PMCIDPMC4425239 (opens in a new tab)DOI10.2147/dddt.s82030 (opens in a new tab)PepBankPUB-25995620
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with alkali burns, topical BPC‑157 accelerated wound closure.

    In plain wordsIn rats with chemical skin burns, BPC‑157 applied to the skin sped up wound closure.

    Peptide
    BPC-157
    Outcome
    IncreaseWound closure after alkali burn
    Study

    ratn: not reported in source

    alkali burn wound
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topicalAs given in this study (rat).

    Source sentences

    Summary
    Topical treatment with BPC-157 was shown to accelerate wound closure following an alkali burn.
    1 context sentence
    Summary · context
    The present study investigated the effect of topical body protective compound (BPC)-157 treatment on skin wound healing, using an alkali burn rat model.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with alkali burns, BPC‑157 gave better granulation tissue formation than the model control on day 18.

    In plain wordsIn rats with chemical skin burns, BPC‑157 gave better new tissue formation than no treatment.

    Peptide
    BPC-157
    Outcome
    IncreaseGranulation tissue formation (day 18)
    Study

    ratn: not reported in source

    alkali burn wound
    Comparator
    Model control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topicalAs given in this study (rat).

    Source sentences

    Summary
    Histological examination of skin sections with hematoxylin-eosin and Masson staining showed better granulation tissue formation, reepithelialization, dermal remodeling, and a higher extent of collagen deposition when compared to the model control group on the 18th day postwounding.
    1 context sentence
    Summary · context
    The present study investigated the effect of topical body protective compound (BPC)-157 treatment on skin wound healing, using an alkali burn rat model.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with alkali burns, BPC‑157 gave better reepithelialization than the model control on day 18.

    In plain wordsIn rats with chemical skin burns, BPC‑157 gave better skin surface regrowth than no treatment.

    Peptide
    BPC-157
    Outcome
    IncreaseReepithelialization (day 18)
    Study

    ratn: not reported in source

    alkali burn wound
    Comparator
    Model control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topicalAs given in this study (rat).

    Source sentences

    Summary
    Histological examination of skin sections with hematoxylin-eosin and Masson staining showed better granulation tissue formation, reepithelialization, dermal remodeling, and a higher extent of collagen deposition when compared to the model control group on the 18th day postwounding.
    1 context sentence
    Summary · context
    The present study investigated the effect of topical body protective compound (BPC)-157 treatment on skin wound healing, using an alkali burn rat model.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with alkali burns, BPC‑157 gave better dermal remodeling than the model control on day 18.

    In plain wordsIn rats with chemical skin burns, BPC‑157 gave better remodeling of the deeper skin than no treatment.

    Peptide
    BPC-157
    Outcome
    IncreaseDermal remodeling (day 18)
    Study

    ratn: not reported in source

    alkali burn wound
    Comparator
    Model control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topicalAs given in this study (rat).

    Source sentences

    Summary
    Histological examination of skin sections with hematoxylin-eosin and Masson staining showed better granulation tissue formation, reepithelialization, dermal remodeling, and a higher extent of collagen deposition when compared to the model control group on the 18th day postwounding.
    1 context sentence
    Summary · context
    The present study investigated the effect of topical body protective compound (BPC)-157 treatment on skin wound healing, using an alkali burn rat model.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with alkali burns, BPC‑157 gave a higher extent of collagen deposition than the model control on day 18.

    In plain wordsIn rats with chemical skin burns, BPC‑157 gave more collagen deposit than no treatment.

    Peptide
    BPC-157
    Outcome
    IncreaseCollagen deposition (day 18)
    Study

    ratn: not reported in source

    alkali burn wound
    Comparator
    Model control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topicalAs given in this study (rat).

    Source sentences

    Summary
    Histological examination of skin sections with hematoxylin-eosin and Masson staining showed better granulation tissue formation, reepithelialization, dermal remodeling, and a higher extent of collagen deposition when compared to the model control group on the 18th day postwounding.
    1 context sentence
    Summary · context
    The present study investigated the effect of topical body protective compound (BPC)-157 treatment on skin wound healing, using an alkali burn rat model.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with alkali burns, BPC‑157 promoted vascular endothelial growth factor expression in wounded skin.

    In plain wordsIn rats with chemical skin burns, BPC‑157 raised a blood vessel growth factor in the wounded skin.

    Peptide
    BPC-157
    Outcome
    IncreaseVEGF expression in wounded skin
    Study

    ratn: not reported in source

    alkali burn wound
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topicalAs given in this study (rat).

    Source sentences

    Summary
    BPC-157 could promote vascular endothelial growth factor expression in wounded skin tissues.
    1 context sentence
    Summary · context
    The present study investigated the effect of topical body protective compound (BPC)-157 treatment on skin wound healing, using an alkali burn rat model.
  7. 07LabIn vitro (cells)Efficacy outcome

    In human umbilical vein endothelial cells, BPC‑157 enhanced proliferation.

    In plain wordsIn cells, BPC‑157 increased the growth of blood vessel lining cells.

    Peptide
    BPC-157
    Outcome
    IncreaseHUVEC proliferation
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and cell cycle analysis demonstrated that BPC-157 enhanced the proliferation of human umbilical vein endothelial cells (HUVECs).
  8. 08LabIn vitro (cells)Efficacy outcome

    In human umbilical vein endothelial cells, BPC‑157 significantly promoted migration.

    In plain wordsIn cells, BPC‑157 increased the movement of blood vessel lining cells.

    Peptide
    BPC-157
    Outcome
    IncreaseHUVEC migration
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Transwell assay and wound healing assay showed that BPC-157 significantly promoted migration of HUVECs.
  9. 09LabIn vitro (cells)Mechanism

    In vitro, BPC‑157 upregulated the expression of VEGF-a.

    In plain wordsIn cells, BPC‑157 raised the level of a blood vessel growth factor.

    Peptide
    BPC-157
    Outcome
    IncreaseVEGF-a expression in vitro
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC-157 upregulated the expression of VEGF-a
  10. 10LabIn vitro (cells)Efficacy outcome

    In vitro, BPC‑157 accelerated vascular tube formation.

    In plain wordsIn cells, BPC‑157 sped up the formation of blood vessel-like tubes.

    Peptide
    BPC-157
    Outcome
    IncreaseVascular tube formation in vitro
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    accelerated vascular tube formation in vitro.
  11. 11LabIn vitro (cells)Mechanism

    BPC‑157 regulated the phosphorylation level of extracellular signal-regulated kinases 1 and 2 (ERK1/2).

    In plain wordsIn cells, BPC‑157 changed the activation of a cell growth signal called ERK1/2.

    Peptide
    BPC-157
    Outcome
    Direction not reportedERK1/2 phosphorylation
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC-157 regulated the phosphorylation level of extracellular signal-regulated kinases 1 and 2 (ERK1/2)
  12. 12LabIn vitro (cells)Mechanism

    BPC‑157 regulated the ERK1/2 downstream targets c-Fos, c-Jun and Egr-1.

    In plain wordsIn cells, BPC‑157 changed the activity of signals downstream of ERK1/2 that control cell growth.

    Peptide
    BPC-157
    Outcome
    Direction not reportedERK1/2 downstream targets (c-Fos, c-Jun, Egr-1)
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    as well as its downstream targets, including c-Fos, c-Jun, and Egr-1, which are key molecules involved in cell growth, migration, and angiogenesis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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