Metabolic and Gonadotropic Impact of Sequential Obesogenic Insults in the Female: Influence of the Loss of Ovarian Secretion.

Sánchez-Garrido MA, Ruiz-Pino F, Manfredi-Lozano M, Leon S, Heras V, Castellano JM, Castaño JP, Luque RM, Vázquez MJ, Roa J, Romero-Ruiz A, Diéguez C, Pinilla L, Tena-Sempere M

Endocrinology18 May 2015Cited by 24 (Europe PMC)

PMID25984764DOI10.1210/en.2014-1951PepBankPUB-25984764

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In 4-month female rats, high-fat diet combined with small litter rearing suppressed Kiss1 expression in the hypothalamic arcuate nucleus.
In plain wordsIn young female rats, overnutrition at birth plus a high-fat diet lowered the body's own Kiss1 gene activity in a brain area.
Peptide
Kisspeptin-10
Outcome
DecreaseArcuate nucleus Kiss1 expression after small litter rearing plus high-fat diet
Study
Ratn: not reported in source
Female rats, gonadal-intact and ovariectomised
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
when combined with SL, suppressed Kiss1 expression in the hypothalamic arcuate nucleus in 4-month females, whereas HFD up to 10-month also reduced LH responses to kisspeptin-10.
1 context sentence(design, population, supporting numbers)
Summary · context
We study here the metabolic and gonadotropic impact of sequential obesogenic insults, namely postnatal overnutrition [by rearing in small litters (SL)] and high-fat diet (HFD) after weaning, in gonadal-intact and ovariectomized (OVX) female rats.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2598476402
02AnimalEndogenous levelAnimal study (in vivo)Other
In female rats, ovariectomy abolished the inhibitory effect of overweight and high-fat diet on arcuate nucleus Kiss1 expression.
In plain wordsIn female rats, removing the ovaries removed the lowering effect of overweight and high-fat diet on the body's own Kiss1 activity.
Peptide
Kisspeptin-10
Outcome
No significant changeArcuate Kiss1 expression after ovariectomy and obesogenic insults
Study
Ratn: not reported in source
Female rats, gonadal-intact and ovariectomised
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Yet OVX obliterated the inhibitory effects of overweight/HFD on gonadotropin levels and arcuate nucleus Kiss1 expression.
1 context sentence(design, population, supporting numbers)
Summary · context
We study here the metabolic and gonadotropic impact of sequential obesogenic insults, namely postnatal overnutrition [by rearing in small litters (SL)] and high-fat diet (HFD) after weaning, in gonadal-intact and ovariectomized (OVX) female rats.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2598476403

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

03AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome
In female rats, a high-fat diet up to 10 months reduced the LH response to a kisspeptin‑10 challenge.
In plain wordsIn female rats, a long high-fat diet reduced the luteinising hormone response to kisspeptin‑10, which was used as a test.
Peptide
Kisspeptin-10
Outcome
DecreaseLH response to kisspeptin-10 challenge after high-fat diet
Study
Ratn: not reported in source
Female rats, gonadal-intact and ovariectomised
Comparator
Control diet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
whereas HFD up to 10-month also reduced LH responses to kisspeptin-10.
1 context sentence(design, population, supporting numbers)
Summary · context
We study here the metabolic and gonadotropic impact of sequential obesogenic insults, namely postnatal overnutrition [by rearing in small litters (SL)] and high-fat diet (HFD) after weaning, in gonadal-intact and ovariectomized (OVX) female rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2598476401

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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