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Study · Animal study (in vivo) · mouse · 2015

4 results

ACTH (Acthar Gel) Reduces Toxic SOD1 Protein Linked to Amyotrophic Lateral Sclerosis in Transgenic Mice: A Novel Observation.

Arrat H, Lukas TJ, Siddique T

PloS one8 May 2015Cited by 3 (Europe PMC)

PMID25955410 (opens in a new tab)PMCIDPMC4425507 (opens in a new tab)DOI10.1371/journal.pone.0125638 (opens in a new tab)PepBankPUB-25955410
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Summary

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex etiology and pathology that makes the development of new therapies difficult. ACTH has neurotrophic and myotrophic effects, but has not been tested in an ALS mouse model. The G93A-SOD1 mouse model of ALS was used to test the ability of this drug to delay ALS-like symptoms. We showed that within a specific dose range, ACTH significantly postponed the disease onset and paralysis in the mouse model. To our surprise and of greater significance is that ACTH significantly reduced the levels of soluble SOD1 in the spinal cord and CNS tissues of G93A-SOD1 treated mice as well as cultured fibroblasts.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In G93A-SOD1 mice, Acthar Gel significantly delayed disease onset within a specific dose range.

    In plain wordsIn mice with an ALS model, Acthar Gel significantly delayed disease onset within a specific dose range.

    Peptide
    ACTH (corticotropin)
    Outcome
    IncreaseDisease onset
    Study

    mousen: not reported in source

    G93A-SOD1 ALS mouse model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We showed that within a specific dose range, ACTH significantly postponed the disease onset and paralysis in the mouse model.
    2 context sentences
    Title · context
    ACTH (Acthar Gel) Reduces Toxic SOD1 Protein Linked to Amyotrophic Lateral Sclerosis in Transgenic Mice: A Novel Observation.
    Summary · context
    The G93A-SOD1 mouse model of ALS was used to test the ability of this drug to delay ALS-like symptoms.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In G93A-SOD1 mice, Acthar Gel significantly delayed paralysis within a specific dose range.

    In plain wordsIn mice with an ALS model, Acthar Gel significantly delayed paralysis within a specific dose range.

    Peptide
    ACTH (corticotropin)
    Outcome
    IncreaseParalysis onset
    Study

    mousen: not reported in source

    G93A-SOD1 ALS mouse model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We showed that within a specific dose range, ACTH significantly postponed the disease onset and paralysis in the mouse model.
    2 context sentences
    Title · context
    ACTH (Acthar Gel) Reduces Toxic SOD1 Protein Linked to Amyotrophic Lateral Sclerosis in Transgenic Mice: A Novel Observation.
    Summary · context
    The G93A-SOD1 mouse model of ALS was used to test the ability of this drug to delay ALS-like symptoms.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In treated G93A-SOD1 mice, Acthar Gel significantly reduced soluble SOD1 in the spinal cord.

    In plain wordsIn mice with an ALS model, Acthar Gel reduced soluble SOD1 in the spinal cord.

    Peptide
    ACTH (corticotropin)
    Outcome
    DecreaseSoluble SOD1 in spinal cord
    Study

    mousen: not reported in source

    G93A-SOD1 ALS mouse model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    To our surprise and of greater significance is that ACTH significantly reduced the levels of soluble SOD1 in the spinal cord and CNS tissues of G93A-SOD1 treated mice
    2 context sentences
    Title · context
    ACTH (Acthar Gel) Reduces Toxic SOD1 Protein Linked to Amyotrophic Lateral Sclerosis in Transgenic Mice: A Novel Observation.
    Summary · context
    The G93A-SOD1 mouse model of ALS was used to test the ability of this drug to delay ALS-like symptoms.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In treated G93A-SOD1 mice, Acthar Gel significantly reduced soluble SOD1 in CNS tissues.

    In plain wordsIn mice with an ALS model, Acthar Gel reduced soluble SOD1 in central nervous system tissues.

    Peptide
    ACTH (corticotropin)
    Outcome
    DecreaseSoluble SOD1 in CNS tissues
    Study

    mousen: not reported in source

    G93A-SOD1 ALS mouse model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    To our surprise and of greater significance is that ACTH significantly reduced the levels of soluble SOD1 in the spinal cord and CNS tissues of G93A-SOD1 treated mice
    2 context sentences
    Title · context
    ACTH (Acthar Gel) Reduces Toxic SOD1 Protein Linked to Amyotrophic Lateral Sclerosis in Transgenic Mice: A Novel Observation.
    Summary · context
    The G93A-SOD1 mouse model of ALS was used to test the ability of this drug to delay ALS-like symptoms.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

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