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Study · Animal study (in vivo) · rat · 2015

5 results

Effect of Thymosin β4 on the Survival of Random Skin Flaps in Rats.

Lin Y, Lin B, Lin D, Huang G, Cao B

Journal of reconstructive microsurgery4 May 2015Cited by 17 (Europe PMC)

PMID25938932 (opens in a new tab)DOI10.1055/s-0035-1549444 (opens in a new tab)PepBankPUB-25938932
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with random-pattern skin flaps, thymosin β4 reduced the necrotic area at 7 days versus saline control.

    In plain wordsIn rats with skin flaps, thymosin β4 reduced the dead tissue area after 7 days compared with saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseNecrotic area of random skin flaps at 7 days
    Study

    ratn = 45

    random-pattern skin flap, Sprague-Dawley
    Comparator
    Saline control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 mg/kg once or twice per day · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Thymosin β4 significantly reduced the necrotic area in the treatment groups after 7 days compared with the control group, and the rats receiving thymosin β4 5 mg/kg twice per day had the highest survival rate.
    2 context sentences
    Summary · context
    A total of 45 male Sprague-Dawley rats were used and subjected to a random-pattern skin flaps operation.
    Summary · context
    Rats were randomly divided into three groups: a control group (group A: intraperitoneal injection of saline, 5 mg/kg/d) and two treatment groups (group B: intraperitoneal injection of thymosin β4, a single 5 mg/kg dose per day) and (group C: intraperitoneal injection of thymosin β4, 5 mg/kg dose twice per day).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with random-pattern skin flaps, the group given thymosin β4 5 mg/kg twice per day had the highest survival rate.

    In plain wordsIn rats with skin flaps, the group given thymosin β4 twice per day had the highest flap survival.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseFlap survival rate by dose
    Study

    ratn = 45

    random-pattern skin flap, Sprague-Dawley
    Comparator
    Saline control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 mg/kg twice per day · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    the rats receiving thymosin β4 5 mg/kg twice per day had the highest survival rate.
    2 context sentences
    Summary · context
    A total of 45 male Sprague-Dawley rats were used and subjected to a random-pattern skin flaps operation.
    Summary · context
    Rats were randomly divided into three groups: a control group (group A: intraperitoneal injection of saline, 5 mg/kg/d) and two treatment groups (group B: intraperitoneal injection of thymosin β4, a single 5 mg/kg dose per day) and (group C: intraperitoneal injection of thymosin β4, 5 mg/kg dose twice per day).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with random-pattern skin flaps, VEGF expression rose in the thymosin β4 groups versus control.

    In plain wordsIn rats with skin flaps, thymosin β4 groups showed more VEGF than the control group.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseVEGF expression in flaps
    Study

    ratn = 45

    random-pattern skin flap, Sprague-Dawley
    Comparator
    Saline control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 mg/kg once or twice per day · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    VEGF expression and SOD activity markedly increased in the treatment groups compared with the control group, whereas MDA levels were lower in the treatment groups than in the control group.
    2 context sentences
    Summary · context
    A total of 45 male Sprague-Dawley rats were used and subjected to a random-pattern skin flaps operation.
    Summary · context
    Rats were randomly divided into three groups: a control group (group A: intraperitoneal injection of saline, 5 mg/kg/d) and two treatment groups (group B: intraperitoneal injection of thymosin β4, a single 5 mg/kg dose per day) and (group C: intraperitoneal injection of thymosin β4, 5 mg/kg dose twice per day).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with random-pattern skin flaps, SOD activity rose in the thymosin β4 groups versus control.

    In plain wordsIn rats with skin flaps, thymosin β4 groups had higher SOD enzyme activity than the control group.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSOD activity in flaps
    Study

    ratn = 45

    random-pattern skin flap, Sprague-Dawley
    Comparator
    Saline control
    Outcome group
    Oxidative stress · Skin and wound
    Studied dose
    5 mg/kg once or twice per day · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    VEGF expression and SOD activity markedly increased in the treatment groups compared with the control group, whereas MDA levels were lower in the treatment groups than in the control group.
    2 context sentences
    Summary · context
    A total of 45 male Sprague-Dawley rats were used and subjected to a random-pattern skin flaps operation.
    Summary · context
    Rats were randomly divided into three groups: a control group (group A: intraperitoneal injection of saline, 5 mg/kg/d) and two treatment groups (group B: intraperitoneal injection of thymosin β4, a single 5 mg/kg dose per day) and (group C: intraperitoneal injection of thymosin β4, 5 mg/kg dose twice per day).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with random-pattern skin flaps, MDA levels were lower in the thymosin β4 groups than in control.

    In plain wordsIn rats with skin flaps, thymosin β4 groups had lower MDA levels than the control group.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseMDA content in flaps
    Study

    ratn = 45

    random-pattern skin flap, Sprague-Dawley
    Comparator
    Saline control
    Outcome group
    Oxidative stress · Skin and wound
    Studied dose
    5 mg/kg once or twice per day · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    VEGF expression and SOD activity markedly increased in the treatment groups compared with the control group, whereas MDA levels were lower in the treatment groups than in the control group.
    2 context sentences
    Summary · context
    A total of 45 male Sprague-Dawley rats were used and subjected to a random-pattern skin flaps operation.
    Summary · context
    Rats were randomly divided into three groups: a control group (group A: intraperitoneal injection of saline, 5 mg/kg/d) and two treatment groups (group B: intraperitoneal injection of thymosin β4, a single 5 mg/kg dose per day) and (group C: intraperitoneal injection of thymosin β4, 5 mg/kg dose twice per day).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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