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Study · Animal study (in vivo) · 2017

5 results

Thymosin β4 has a major role in dermal burn wound healing that involves actin cytoskeletal remodelling via heat-shock protein 70.

Kim S, Kwon J

Journal of tissue engineering and regenerative medicine28 Apr 2015Cited by 16 (Europe PMC)

PMID25921810 (opens in a new tab)DOI10.1002/term.2028 (opens in a new tab)PepBankPUB-25921810
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In an adapted dermal burn wound in vivo model, Tβ4 improved wound closure.

    In plain wordsIn an animal burn wound model, thymosin β4 improved wound closure.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseWound closure in dermal burn wound model
    Study

    n: not reported in source

    adapted dermal burn wound in vivo model
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 improved wound-healing markers, such as wound closure and vascularization.
    2 context sentences
    Summary · context
    Based on these in vitro results, we confirmed the healing effects of Tβ4 in an adapted dermal burn wound in vivo model.
    Summary · context
    In the present study, we investigated how Tβ4 improves dermal burn wound healing via actin cytoskeletal remodelling and the action of heat-shock proteins (HSPs), which are a vital set of chaperone proteins that respond to heat shock.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In an adapted dermal burn wound in vivo model, Tβ4 improved vascularization.

    In plain wordsIn an animal burn wound model, thymosin β4 improved blood vessel growth in the wound.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseVascularization in dermal burn wound model
    Study

    n: not reported in source

    adapted dermal burn wound in vivo model
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 improved wound-healing markers, such as wound closure and vascularization.
    2 context sentences
    Summary · context
    Based on these in vitro results, we confirmed the healing effects of Tβ4 in an adapted dermal burn wound in vivo model.
    Summary · context
    In the present study, we investigated how Tβ4 improves dermal burn wound healing via actin cytoskeletal remodelling and the action of heat-shock proteins (HSPs), which are a vital set of chaperone proteins that respond to heat shock.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In an adapted dermal burn wound in vivo model, Tβ4 maintained long-term expression of HSP70 during the wound-healing period.

    In plain wordsIn an animal burn wound model, thymosin β4 kept HSP70 levels up during healing.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseLong-term HSP70 expression during wound healing
    Study

    n: not reported in source

    adapted dermal burn wound in vivo model
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, Tβ4 maintained the long-term expression of HSP70, which is associated with F-actin regulation during the wound-healing period.
    2 context sentences
    Summary · context
    Based on these in vitro results, we confirmed the healing effects of Tβ4 in an adapted dermal burn wound in vivo model.
    Summary · context
    In the present study, we investigated how Tβ4 improves dermal burn wound healing via actin cytoskeletal remodelling and the action of heat-shock proteins (HSPs), which are a vital set of chaperone proteins that respond to heat shock.
  4. 04LabIn vitro (cells)Mechanism

    In human umbilical vein endothelial cells, Tβ4 showed a possible signal link with HSP70.

    In plain wordsIn cells, thymosin β4 appeared to be linked to a heat-shock protein called HSP70.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableSignal between Tβ4 and HSP70 in HUVECs
    Study

    humann: not reported in source

    human umbilical vein endothelial cells (HUVECs)
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our in vitro results achieved with the use of human umbilical vein endothelial cells (HUVECs) revealed a possible signal between Tβ4 and HSP70.
    1 context sentence
    Summary · context
    In the present study, we investigated how Tβ4 improves dermal burn wound healing via actin cytoskeletal remodelling and the action of heat-shock proteins (HSPs), which are a vital set of chaperone proteins that respond to heat shock.
  5. 05LabIn vitro (cells)Mechanism

    In human umbilical vein endothelial cells, Tβ4-induced HSP70 regulated the remodelling of filamentous actin (F-actin).

    In plain wordsIn cells, thymosin β4 acted through HSP70 to change the actin skeleton of the cell.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableF-actin remodelling regulated by Tβ4-induced HSP70
    Study

    humann: not reported in source

    human umbilical vein endothelial cells (HUVECs)
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, we confirmed that remodelling of filamentous actin (F-actin) was regulated by Tβ4-induced HSP70 in HUVECs.
    1 context sentence
    Summary · context
    In the present study, we investigated how Tβ4 improves dermal burn wound healing via actin cytoskeletal remodelling and the action of heat-shock proteins (HSPs), which are a vital set of chaperone proteins that respond to heat shock.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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