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Study · Animal study (in vivo) · rat · 2015

7 results

Perforating corneal injury in rat and pentadecapeptide BPC 157.

Masnec S, Kokot A, Zlatar M, Kalauz M, Kunjko K, Radic B, Klicek R, Drmic D, Lazic R, Brcic L, Radic R, Ivekovic R, Seiwerth S, Sikiric P

Experimental eye research24 Apr 2015Cited by 24 (Europe PMC)

PMID25912999 (opens in a new tab)DOI10.1016/j.exer.2015.04.016 (opens in a new tab)PepBankPUB-25912999
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with a perforating corneal incision, BPC‑157 at 2 µg and 2 ng significantly accelerated healing from 24 h after injury, compared with controls.

    In plain wordsIn rats with an eye injury, BPC‑157 eye drops sped up healing compared with water drops.

    Peptide
    BPC-157
    Outcome
    IncreaseHealing of perforating corneal incision
    Study

    ratn: not reported in source

    Comparator
    Distilled water
    Outcome group
    Wound healing · Eye
    Studied dose
    2 µg/mL and 2 ng/mL · eye drops · up to 120 hoursAs given in this study (rat).

    Source sentences

    Summary
    In contrast to the poor healing response in controls, BPC 157 significantly accelerated the healing process in 2 μg and 2 ng BPC 157-treated eyes, starting 24 h after the injury, and the fluorescein and Seidel tests became negative.
    1 context sentence
    Summary · context
    We made a penetrant linear 2-mm incision in the paralimbal region of the left cornea at the 5 o'clock position with a 20-gauge MVR incision knife at 45° under an operating microscope.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with a perforating corneal incision treated with BPC‑157, the fluorescein and Seidel tests became negative.

    In plain wordsIn rats with an eye injury treated with BPC‑157, the leak tests became negative.

    Peptide
    BPC-157
    Outcome
    DecreaseFluorescein and Seidel tests
    Study

    ratn: not reported in source

    Comparator
    Distilled water
    Outcome group
    Wound healing · Eye
    Studied dose
    2 µg/mL and 2 ng/mL · eye drops · up to 120 hoursAs given in this study (rat).

    Source sentences

    Summary
    In contrast to the poor healing response in controls, BPC 157 significantly accelerated the healing process in 2 μg and 2 ng BPC 157-treated eyes, starting 24 h after the injury, and the fluorescein and Seidel tests became negative.
    1 context sentence
    Summary · context
    We made a penetrant linear 2-mm incision in the paralimbal region of the left cornea at the 5 o'clock position with a 20-gauge MVR incision knife at 45° under an operating microscope.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with a perforating corneal incision, epithelial defects were completely healed at 72 h with 2 µg BPC‑157.

    In plain wordsIn rats with an eye injury, 2 µg BPC‑157 eye drops completely healed the surface defect at 72 hours.

    Peptide
    BPC-157
    Outcome
    DecreaseTime to complete epithelial healing, 2 µg dose
    Study

    ratn: not reported in source

    Comparator
    Distilled water
    Outcome group
    Wound healing · Eye
    Studied dose
    2 µg/mL · eye drops · up to 120 hoursAs given in this study (rat).

    Measurements

    Time to complete epithelial healing
    72 h
    2 µg BPC 157

    Source sentences

    Summary
    The epithelial defects were completely healed at 72 h (2 μg BPC 157-treated group)
    1 context sentence
    Summary · context
    We made a penetrant linear 2-mm incision in the paralimbal region of the left cornea at the 5 o'clock position with a 20-gauge MVR incision knife at 45° under an operating microscope.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with a perforating corneal incision, epithelial defects were completely healed at 96 h with 2 ng BPC‑157.

    In plain wordsIn rats with an eye injury, 2 ng BPC‑157 eye drops completely healed the surface defect at 96 hours.

    Peptide
    BPC-157
    Outcome
    DecreaseTime to complete epithelial healing, 2 ng dose
    Study

    ratn: not reported in source

    Comparator
    Distilled water
    Outcome group
    Wound healing · Eye
    Studied dose
    2 ng/mL · eye drops · up to 120 hoursAs given in this study (rat).

    Measurements

    Time to complete epithelial healing
    96 h
    2 ng BPC 157

    Source sentences

    Summary
    The epithelial defects were completely healed at 72 h (2 μg BPC 157-treated group) and at 96 h (2 ng BPC 157-treated group) after injury.
    1 context sentence
    Summary · context
    We made a penetrant linear 2-mm incision in the paralimbal region of the left cornea at the 5 o'clock position with a 20-gauge MVR incision knife at 45° under an operating microscope.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with a perforating corneal incision, aqueous cells were absent at 96 h after injury with 2 µg BPC‑157.

    In plain wordsIn rats with an eye injury, 2 µg BPC‑157 eye drops cleared inflammatory cells from the eye fluid by 96 hours.

    Peptide
    BPC-157
    Outcome
    DecreaseAqueous cells, 2 µg dose
    Study

    ratn: not reported in source

    Comparator
    Distilled water
    Outcome group
    Wound healing · Eye
    Studied dose
    2 µg/mL · eye drops · up to 120 hoursAs given in this study (rat).

    Measurements

    Time to absence of aqueous cells
    96 h
    2 µg BPC 157

    Source sentences

    Summary
    Aqueous cells were absent at 96 h and 120 h after injury in the 2 μg and 2 ng BPC 157-treated groups, respectively.
    1 context sentence
    Summary · context
    We made a penetrant linear 2-mm incision in the paralimbal region of the left cornea at the 5 o'clock position with a 20-gauge MVR incision knife at 45° under an operating microscope.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with a perforating corneal incision, aqueous cells were absent at 120 h after injury with 2 ng BPC‑157.

    In plain wordsIn rats with an eye injury, 2 ng BPC‑157 eye drops cleared inflammatory cells from the eye fluid by 120 hours.

    Peptide
    BPC-157
    Outcome
    DecreaseAqueous cells, 2 ng dose
    Study

    ratn: not reported in source

    Comparator
    Distilled water
    Outcome group
    Wound healing · Eye
    Studied dose
    2 ng/mL · eye drops · up to 120 hoursAs given in this study (rat).

    Measurements

    Time to absence of aqueous cells
    120 h
    2 ng BPC 157

    Source sentences

    Summary
    Aqueous cells were absent at 96 h and 120 h after injury in the 2 μg and 2 ng BPC 157-treated groups, respectively.
    1 context sentence
    Summary · context
    We made a penetrant linear 2-mm incision in the paralimbal region of the left cornea at the 5 o'clock position with a 20-gauge MVR incision knife at 45° under an operating microscope.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with a perforating corneal incision, BPC‑157-treated rats generally had no new vessels, unlike controls, which developed new vessels from the limbus to the penetrated area.

    In plain wordsIn rats with an eye injury, BPC‑157 eye drops mostly prevented new blood vessels from growing toward the wound, unlike water drops.

    Peptide
    BPC-157
    Outcome
    DecreaseNew corneal vessel growth
    Study

    ratn: not reported in source

    Comparator
    Distilled water
    Outcome group
    Wound healing · Eye
    Studied dose
    2 pg/mL, 2 ng/mL and 2 µg/mL · eye drops · up to 120 hoursAs given in this study (rat).

    Source sentences

    Summary
    Whereas controls developed new vessels that grew from the limbus to the penetrated area, BPC 157-treated rats generally had no new vessels, and those that did form in the limbus did not make contact with the penetrated area.
    1 context sentence
    Summary · context
    We made a penetrant linear 2-mm incision in the paralimbal region of the left cornea at the 5 o'clock position with a 20-gauge MVR incision knife at 45° under an operating microscope.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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