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Study · Measured the body's own peptide · 2014

3 results

[Association of intracellular proteinase activities with the content of locomotor proteins in tissues of primary tumors and metastasis in ovarian cancer].

Kondakova IV, Iunusova NV, Spirina LV, Kolomiets LA, Villert AB

Bioorganicheskaia khimiia1 Nov 2014Cited by 12 (Europe PMC)

PMID25895370 (opens in a new tab)DOI10.1134/s1068162014060089 (opens in a new tab)PepBankPUB-25895370
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In ovarian cancer, the content of the body's own thymosin-β4 was significantly lower in primary tumors and metastases than in normal tissues.

    In plain wordsIn people with ovarian cancer, natural thymosin beta‑4 levels were lower in tumor tissue than in normal tissue.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymosin-β4 content in primary ovarian tumors and metastases versus normal tissue
    Study

    n: not reported in source

    ovarian cancer tissue samples
    Comparator
    Normal tissue
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    In ovarian cancer significant reduction in the number of the monomer binder protein thymosin-β4 was observed in primary tumors and metastases as compared to normal tissues, but significant differences between the primary tumor and metastases were not observed.
    1 context sentence
    Summary · context
    We studied the expression of actin-binding proteins and β-catenin in connection with proteasome and calpain functioning in the tissues of primary tumors and metastases of ovarian cancer.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In ovarian cancer, no significant difference in thymosin-β4 content was observed between primary tumors and metastases.

    In plain wordsIn people with ovarian cancer, natural thymosin beta‑4 levels did not differ clearly between the first tumor and its metastases.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeThymosin-β4 content in metastases versus primary tumors
    Study

    n: not reported in source

    ovarian cancer tissue samples
    Comparator
    Primary tumor
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    significant differences between the primary tumor and metastases were not observed.
    1 context sentence
    Summary · context
    We studied the expression of actin-binding proteins and β-catenin in connection with proteasome and calpain functioning in the tissues of primary tumors and metastases of ovarian cancer.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In ovarian cancer metastases, calpain activity correlated negatively with the content of thymosin, Arp3 and cofilin.

    In plain wordsIn people with ovarian cancer, higher calpain activity in metastases was linked to lower natural thymosin levels.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCorrelation of calpain activity with thymosin content in metastases
    Study

    n: not reported in source

    ovarian cancer tissue samples
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    In metastasis negative correlation were revealed between the activity of calpain and content Arp3, cofilin, thymosin.
    1 context sentence
    Summary · context
    We studied the expression of actin-binding proteins and β-catenin in connection with proteasome and calpain functioning in the tissues of primary tumors and metastases of ovarian cancer.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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